Synthesis of saccharide precursors for preparation of potential inhibitors of glycosyltranferases
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Ján Hirsch
,
Miroslav Koóš
Abstract
Ethyl 6-O-tert-butyldimethylsilyl-3,4-di-O-acetyl-2-thio-α-D-fructofuranoside (Va), its β-analog (Vb); as well as benzyl 6-O-tert-butyldimethylsilyl-3,4-di-O-acetyl-2-thio-α-D-fructofuranoside (Xa) and its β-analog (Xb), having an unprotected OH group at C-1, were prepared by sequential synthesis starting from commercially available D-fructose. These compounds represent suitable nucleophiles for the preparation of model carbohydrate mimetics of a glycosyltransferase inhibitor type in transition state. The structures of all compounds were confirmed by NMR spectral data and elemental analyses.
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© 2008 Institute of Chemistry, Slovak Academy of Sciences
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Artikel in diesem Heft
- Application of isotachophoretic and conductometric methods for neomycin trisulphate determination
- A rhodamine-based Hg2+-selective fluorescent probe in aqueous solution
- A simple flow injection spectrophotometric determination method for iron(III) based on O-acetylsalicylhydroxamic acid complexation
- Global optimization for parameter estimation of differential-algebraic systems
- Effect of ethyl acetate on carbohydrate components and crystalline structure of pulp produced in aqueous acetic acid pulping
- Effects of acyl donor type, catalyst type, and reaction conditions on the activity and selectivity of Friedel-Crafts acylation
- Intramolecular MLOH/π and MLNH/π interactions in crystal structures of metal complexes
- A strategy for new macrocycle magnetic materials synthesis
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- New Cu(II), Co(II), and Ni(II) complexes with thieno[2,3-b]pyridine and 2-methylthieno[2,3-b]pyridine as ligands: Synthesis and crystal structures
- Synthesis of saccharide precursors for preparation of potential inhibitors of glycosyltranferases
- Simultaneous spectrophotometric determination of minoxidil and tretinoin by the H-point standard addition method and partial least squares
- Adsorption and release of terbinafine hydrochloride: Effects of adsorbents, additives, pH, and temperature
- Determination of alkaloids in Corydalis yanhusuo using hollow-fibre liquid phase microextraction and high performance liquid chromatography
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- A rapid in vitro assay of cobalamin in human urine and medical tablets using ICP-MS
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