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Production of p-Anisic Acid by Modified Williamson Etherification Reaction Using Design of Experiments
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Pankaj J. Gandhi
Veröffentlicht/Copyright:
13. April 2010
Majority of the processes available for manufacturing of p-anisic acid (4-methoxy benzoic acid) are pertaining to large-scale production comprising of heterogeneous and homogeneous catalysis. These are involved with hazardous and highly toxic materials, involving complex processes, which are not suitable for small-scale industries. The present work has been conducted in a small-scale industry laboratory. A modified Williamson etherification reaction has been studied through process validation and design of experiments (DOE). It is observed that the yield is affected by the process factors; such as mole ratio, addition temperature, reaction temperature, time of addition (or dosage rate), and agitator speed. The maximum yield can be derived by setting the time of addition (120 min) and agitator speed (300 rpm). This simple process may serve the purpose of small scale industry to derive this important product through less hazardous and toxic chemicals with high yield.
Published Online: 2010-4-13
©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston
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Schlagwörter für diesen Artikel
anisic acid;
Williamson etherification;
design of experiments;
TLC;
HPLC;
NMR
Artikel in diesem Heft
- Article
- Influence of Temperature and Pressure on the Non-Catalytic Partial Oxidation of Natural Gas
- CFD Simulation of Hydraulics of Sieve Trays with Gas Mal-Distribution
- Experimental Measurement and Modeling of Diffusion Anomalies in a CMS Membrane
- Moisture Diffusivity and Energy Consumption during Microwave Drying of Plaster of Paris
- Optimization studies on Biosorption of Copper (II) by Crab Shell Using Response Surface Methodology(RSM)
- Simulation and Control of a Commercial Double Effect Evaporator: Tomato Juice
- Novel PCA-Based Technique for Identification of Dominant Variables for Partial Control
- Search for Optimal Design of Multiproduct Batch Plants under Uncertain Demand using Gaussian Process Modeling Solved by Heuristics Methods
- Adsorption of Crude Oil Using Meshed Groundnut Husk
- Revisiting Reaction-Diffusion Process in a Porous Catalyst: Improving the Adomian Solution
- Combining Design of Experiments Techniques, Connectionist Models, and Optimization for the Efficient Design of New Product Formulations
- Simulation and Analysis of Multi-scale Transport Phenomena and Catalytic Reactions in SOFC Anodes
- Utilization of MATLAB to Simulate Kinetics of Transesterification of Palm Oil-Based Methyl Esters with Trimethylolpropane for Biodegradable Synthetic Lubricant Synthesis
- A Fault Detection and Diagnosis Strategy for Batch/Semi-Batch Processes
- Kinetic Study and Modeling of Aerobic Biological Oxidation of Organic Wastewater
- Conceptual Screening of Reactive Extraction Processing Options
- Production of p-Anisic Acid by Modified Williamson Etherification Reaction Using Design of Experiments
- Empty Spray Sections of Vacuum Towers: Heat and Mass Transfer with a CFD approach
- Influence of Phase Compositions, pH and Temperature on Bovine Serum Albumin Partitioning in Aqueous Biphasic System
- Separation of Organic Chlorine Compounds through Batch Distillation Process
- Modeling of Infrared Drying of Polymer Solutions
- An Object-Oriented Graphics Interface Simulator for Analysis of Fischer-Tropsch Synthesis
- CFD Simulation of Wall Effects in Flow Past a Square Cylinder in a Stationary and Moving Plane Channel
- Axial Variation of Mass Transfer Volumetric Coefficients in Bubble Column Bioreactors
- Thermodynamics of Supercritical Fluid Extraction of Some Dyes and Pharmaceutical Compounds Using the Weighting Matrix Approach
- Study of Numerous Injections into Horizontal Flow Stream at Low Temperature
- Bayesian Network Method for Fault Diagnosis in a Continuous Tubular Reactor
- Isotherm and Kinetics Modeling of Fluoride Removal from Industrial Effluent by Alumina
- Effect of Temperature and Catalyst Concentrations on the Thermal Properties of Polyamide Adhesives at Low Operating Pressure
- Microfluidics of Nanodrug Delivery at Different Angles of Drug Injection
- Optimization of Process Variables for Amylase Production Using Agro Residual Wastes by Taguchi Methodology
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