Protective Effects of Silymarin against Free Radical-Induced Erythrocyte Lysis
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Gholamreza Karimi
The oxidative hemolysis of rat erythrocytes induced by 2,2’-azobis–(2-amidinopropane) (AAPH) and its inhibition by silymarin studied. Different concentrations of silymarin showed no significant hemolysis compared with phosphate buffer solution. AAPH (25 mM and 50 mM) induced hemolysis in a time-dependent manner. Silymarin inhibited AAPH (25 mM)-induced hemolysis concentration-dependently. However, in the presence of 50 mM of AAPH, only the two higher concentrations of silymarin inhibited hemolysis. Addition of silymarin 3h after incubation with AAPH (25 mM), had no significant effects on the time course of cell lysis. It is concluded that, in addition to its well-established antioxidant effects, silymarin displays cytoprotective properties.
©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston
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Artikel in diesem Heft
- Discussion Paper
- Integrative Health Care: a Need for Change?
- Research Article
- Use of Complementary and Alternative Medicine by Chinese Individuals Living with Cancer in British Columbia
- Update in Pre-Clinical Regulatory Requirements for Phytomedicines in Latin America
- Spirituality and Adaptive Coping Styles in German Patients with Chronic Diseases in a CAM Health Care Setting
- Complementary/Alternative Medicine in Latin America: Use of Herbal Remedies among a Brazilian Metropolitan Area Population
- The Effects of a Decoction Prepared from the Leaves and Unripe Fruits of Crataegus aronia in Streptozotocin-Induced Diabetic Rats
- Protective Effects of Silymarin against Free Radical-Induced Erythrocyte Lysis
- Conference Presentation
- Integrating CAM Research and Practice: A Focus on Outcome Measures - Abstracts from the 3rd Annual IN-CAM Symposium November 4th & 5th, 2006, Calgary, Canada
