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Surface-modified phillipsite-rich tuff from the Campania region (southern Italy) as a promising drug carrier: An ibuprofen sodium salt trial

  • Mariano Mercurio EMAIL logo , Francesco Izzo , Alessio Langella , Celestino Grifa , Chiara Germinario , Aleksandra Daković , Paolo Aprea , Rossana Pasquino , Piergiulio Cappelletti , Fabio Sossio Graziano and Bruno de Gennaro
Published/Copyright: April 30, 2018
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Abstract

The encapsulation and delivery of drugs often involves the use of expensive microporous materials, and we have investigated the potential for natural zeolites from the widespread volcanic formations of southern Italy as alternatives to these carriers. Surface-modified natural zeolites (SMNZs) with diverse micellar structures (patchy and complete bilayers) were obtained by using different cationic surfactants [cetylpyridinium chloride (CP-Cl), benzalkonium chloride (BC-Cl), hexadecyltrimethylammonium chloride (HDTMA-Cl), and bromide (HDTMA-Br) with phillipsite-rich tuff from the Campania region (southern Italy)]. Loading and release kinetics tests of sodium ibuprofen (IBU) were carried out with organo-phillipsite composites using Fourier transform infrared spectroscopy (FTIR) and thermal analysis coupled with evolved gas analysis (EGA). Results from these tests were mathematically modeled to evaluate IBU adsorption and release mechanisms.

The maximum loaded amount of IBU was attained for organo-phillipsite modified with HDTMA-Br (PHB), which showed a complete bilayer micellar structure. Whenever a patchy bilayer micellar structure formed, the lowest adsorptions of IBU were observed. Equilibrium adsorption results were fit using Langmuir, Sips, and Toth models. Pseudo-first-order and pseudo-second-order fits to the loading kinetic data provided significant goodness of fit. Good fits to the release kinetic data were obtained using first-order and Weibull equations, shedding new light on the release mechanism of IBU from phillipsite. The active amount of IBU on the modified zeolite surface was almost totally available for pharmaceutical purposes.


† Special collection papers can be found online at http://www.minsocam.org/MSA/AmMin/special-collections.html.


Acknowledgments

This work was carried out with the financial support of MIUR (Ministero delľIstruzione, delľUniversitá e della Ricerca) Progetti di Ricerca di Interesse Nazionale (PRIN 2010). The authors thank K. Putirka and two anonymous referees for their suggestions, which deeply improved the manuscript. The authors are also in debt to L. Campbell and D.L. Bish for the invaluable contribution to the clarity of the manuscript.

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Received: 2017-10-6
Accepted: 2018-1-29
Published Online: 2018-4-30
Published in Print: 2018-5-25

© 2018 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Review
  2. Biosilica as a source for inspiration in biological materials science
  3. Ab initio study of water speciation in forsterite: Importance of the entropic effect
  4. Surface-modified phillipsite-rich tuff from the Campania region (southern Italy) as a promising drug carrier: An ibuprofen sodium salt trial
  5. Structure of low-order hemimorphite produced in a Zn-rich environment by cyanobacterium Leptolingbya frigida
  6. Formation of dolomite catalyzed by sulfate-driven anaerobic oxidation of methane: Mineralogical and geochemical evidence from the northern South China Sea
  7. Anisotropic growth of olivine during crystallization in basalts from Hawaii: Implications for olivine fabric development
  8. Melting experiments on Fe–Si–S alloys to core pressures: Silicon in the core?
  9. High-pressure phase behavior and equations of state of ThO2 polymorphs
  10. Mafic inputs into the rhyolitic magmatic system of the 2.08 Ma Huckleberry Ridge eruption, Yellowstone
  11. Toward the wider application of 29Si NMR spectroscopy to paramagnetic transition metal silicate minerals and glasses: Fe(II), Co(II), and Ni(II) silicates
  12. Equations of state and phase boundary for stishovite and CaCl2-type SiO2
  13. Insight on gem opal formation in volcanic ash deposits from a supereruption: A case study through oxygen and hydrogen isotopic composition of opals from Lake Tecopa, California, U.S.A
  14. Revisiting the crystal structure of dickite: X-ray diffraction, solid-state NMR, and DFT calculations study
  15. Temperature and pressure effects on the partitioning of V and Sc between clinopyroxene and silicate melt: Implications for mantle oxygen fugacity
  16. Letter
  17. Why natural monazite never becomes amorphous: Experimental evidence for alpha self-healing
  18. New Mineral Names
  19. Book Review
  20. Book Review: Glaciovolcanism on Earth and Mars: Products, Processes and Paleoenvironmental Significance
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