Cyclotron production of 44Sc for clinical application
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Seweryn Krajewski
Abstract
44Sc is a promising β+-emitter for molecular imaging with intermediate half-life of 4 h. Due to the chemical similarity of Sc3+ to the Lu3+ and Y3+ cations, 44Sc-DOTA bioconjugates are expected to demonstrate similar properties in vivo as the 177Lu- and 90Y-bioconjugates, what is important in planning the radionuclide therapy. 44Sc can be obtained from the 44Ti/44Sc generator. An alternative method for 44Sc production can be the irradiation of 44Ca target at small cyclotrons. The aim of our work was to optimize the parameters of 44CaCO3 irradiation and to develop a simple procedure for 44Sc separation from the calcium target. For optimization study, 44CaCO3 targets were irradiated by protons in the energy range of 5.6–17.5 MeV with 9 MeV being found to be the best energy for 44Ca irradiations. A simple and fast separation procedure of 44Sc from calcium target was developed using chelating resin Chelex 100. DOTATATE conjugate was successfully radiolabelled with high yield at elevated temperature using the produced 44Sc. While 44CaCO3 is relatively expensive, the cost of 44Sc-DOTATATE production can be reduced by target recovery. Due to low proton energy required to produce GBq activity level of 44Sc, the availability of 44Sc radioisotope could be enhanced to open new opportunities for applications in medical imaging.
© by Oldenbourg Wissenschaftsverlag, München, Germany
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Artikel in diesem Heft
- Absence of 232,230,228Th enhancement decay by ultrasound exposure
- Complexation of Cm(III) and Eu(III) with 2,6-bis(5-(2,2-dimethylpropyl)-1H-pyrazol-3-yl)pyridine and 2-bromohexanoic acid studied by time-resolved laser fluorescence spectroscopy
- Americium, curium and neodymium analysis in ECRIX-H irradiated pellet: sample preparation for TIMS measurements
- Co-extraction and stripping behavior of trivalent actinides and fission products in N,N-di-2-ethylhexyl-N´,N´-dioctyl-diglycolamide
- Mass spectrometric characterization and quantification of Pu(VI) hydrolysis products
- Effects of aging on PuO2·xH2O particle size in alkaline solution
- Redox behavior of Tc(VII)/Tc(IV) under various reducing conditions in 0.1 M NaCl solutions
- Cyclotron production of 44Sc for clinical application
- Proton irradiation parameters and chemical separation procedure for the bulk production of high-specific-activity 186gRe using WO3 targets
