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One step purification process for no-carrier-added 64Cu produced using enriched nickel target

  • , , , , , , und
Veröffentlicht/Copyright: 28. Januar 2011
Radiochimica Acta
Aus der Zeitschrift Band 99 Heft 10

Abstract

Copper-64 has found many applications in positron emission tomography (PET). Its half-life allows to use it for dosimetric studies associated to copper-67 targeted radiotherapy in cancer treatment. The use of 64Ni(p,n)64Cu nuclear reaction is known to produce 64Cu in large amount and with a high specific activity. In this study, targets were obtained by electroplating onto a gold backing and a typical target irradiation uses 200ߙnA, 17ߙMeV protons during 30ߙmin. After irradiation, pure copper-64 is obtained using only one chromatographic column. Nickel-64 is removed in a first elution step and cobalt isotopes in a second one. The extraction yield for copper-64 is 9±23% and nickel and cobalt impurities are under the detection limit. A recovery process of nickel-64 has also been developed.

Keywords: Copper-64; Production; Nickel-64 electroplating; Chromatographic separation
* Correspondence address: Arronax Cyclotron, 1 rue Aronnax, 44817 Saint-Herblain Cedex, Frankreich,
Published Online: 2011-01-28
Published in Print: 2011-10

© by Oldenbourg Wissenschaftsverlag, Saint-Herblain Cedex, Germany

Artikel in diesem Heft

  1. Preface to WIPR 2010
  2. Development of novel positron emitters for medical applications: nuclear and radiochemical aspects
  3. One step purification process for no-carrier-added 64Cu produced using enriched nickel target
  4. Some experimental studies on 89Zr production
  5. Paving the way to personalized medicine: production of some theragnostic radionuclides at Brookhaven National Laboratory
  6. Development of PET molecular targeting agents with gallium-68
  7. Chemical and biological evaluation of scandium(III)-polyaminopolycarboxylate complexes as potential PET agents and radiopharmaceuticals
  8. Highly stable acyclic bifunctional chelator for 64Cu PET imaging
https://doi.org/10.1524/ract.2011.1821
Schlagwörter für diesen Artikel
Copper-64; Production; Nickel-64 electroplating; Chromatographic separation

Artikel in diesem Heft

  1. Preface to WIPR 2010
  2. Development of novel positron emitters for medical applications: nuclear and radiochemical aspects
  3. One step purification process for no-carrier-added 64Cu produced using enriched nickel target
  4. Some experimental studies on 89Zr production
  5. Paving the way to personalized medicine: production of some theragnostic radionuclides at Brookhaven National Laboratory
  6. Development of PET molecular targeting agents with gallium-68
  7. Chemical and biological evaluation of scandium(III)-polyaminopolycarboxylate complexes as potential PET agents and radiopharmaceuticals
  8. Highly stable acyclic bifunctional chelator for 64Cu PET imaging
Heruntergeladen am 20.4.2026 von https://www.degruyterbrill.com/document/doi/10.1524/ract.2011.1821/html?lang=de
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