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Chemical and biological evaluation of scandium(III)-polyaminopolycarboxylate complexes as potential PET agents and radiopharmaceuticals

  • , , , , , , and
Published/Copyright: August 4, 2011
Radiochimica Acta
From the journal Volume 99 Issue 10

Abstract

Scandium isotopes (44Sc, 47Sc) are more available and their properties are convenient for either PET imaging or radiotherapy. To use them in nuclear medicine, ligands forming complexes with a high stability are necessary. Available experimental data on stability constants for complexes of ligands such as EDTA, DTPA, DOTA, NOTA and TETA with various metal ions have been published. But scandium is the exception since scarce data is available in the literature. Values of stability constants of Sc(III) with the ligands were determined by free-ion selective radiotracer extraction, complemented by 45Sc NMR and potentiometry data. The thermodynamic stability of the Sc-complexes increases in the order TETA < NOTA < EDTA < DTPA < DOTA. The in vitro stability of the Sc(III) complexes was studied in the presence of hydroxyapatite and rat serum to estimate their in vivo stability. The most stable complex was shown to be Sc-DOTA.

Keywords: Scandium complexes; Polyaminopolycarboxylate ligands; Stability; Positron emission tomography
* Correspondence address: Université de Nantes, Ecole des Mines de Nantes/CNRS/IN2P3, 4 rue A. Kastler, PB 20722, Laboratoire Subatech, 44307 Nantes Cedex 3, Frankreich,
Published Online: 2011-08-04
Published in Print: 2011-10

© by Oldenbourg Wissenschaftsverlag, Nantes Cedex 3, Germany

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  5. Paving the way to personalized medicine: production of some theragnostic radionuclides at Brookhaven National Laboratory
  6. Development of PET molecular targeting agents with gallium-68
  7. Chemical and biological evaluation of scandium(III)-polyaminopolycarboxylate complexes as potential PET agents and radiopharmaceuticals
  8. Highly stable acyclic bifunctional chelator for 64Cu PET imaging
https://doi.org/10.1524/ract.2011.1869
Keywords for this article
Scandium complexes; Polyaminopolycarboxylate ligands; Stability; Positron emission tomography

Articles in the same Issue

  1. Preface to WIPR 2010
  2. Development of novel positron emitters for medical applications: nuclear and radiochemical aspects
  3. One step purification process for no-carrier-added 64Cu produced using enriched nickel target
  4. Some experimental studies on 89Zr production
  5. Paving the way to personalized medicine: production of some theragnostic radionuclides at Brookhaven National Laboratory
  6. Development of PET molecular targeting agents with gallium-68
  7. Chemical and biological evaluation of scandium(III)-polyaminopolycarboxylate complexes as potential PET agents and radiopharmaceuticals
  8. Highly stable acyclic bifunctional chelator for 64Cu PET imaging
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