Startseite Naturwissenschaften Cephradine drug release using electrospun chitosan nanofibers incorporated with halloysite nanoclay
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Cephradine drug release using electrospun chitosan nanofibers incorporated with halloysite nanoclay

  • Mahwish Naz , Muhammad Rizwan , Sehrish Jabeen , Abdul Ghaffar , Atif Islam , Nafisa Gull , Atta Rasool , Rafi Ullah Khan , Samar Z. Alshawwa und Munawar Iqbal
Veröffentlicht/Copyright: 21. September 2021
Zeitschrift für Physikalische Chemie
Aus der Zeitschrift Zeitschrift für Physikalische Chemie Band 236 Heft 2

Abstract

The chitosan/polyvinyl alcohol/halloysite nanoclay (CS/PVA/HNC) loaded with cephradine drug electrospun nanofibers (NFs) were fabricated and characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA) techniques. FTIR analysis confirmed the hydrogen bonding between the polymer chain and the developed siloxane linkages. SEM analysis revealed the formation of uniform NFs having beads free and smooth surface with an average diameter in 50–200 nm range. The thermal stability of the NFs was increased by increasing the HNC concentration. The antimicrobial activity was examined against Escherichia  coli and staphylococcus strains and the NFs revealed auspicious antimicrobial potential. The drug release was studied at pH 7.4 (in PBS) at 37 °C. The drug release analysis showed that 90% of the drug was released from NFs in 2 h and 40 min. Hence, the prepared NFs could be used as a potential drug carrier and release in a control manner for biomedical application.

Keywords: cephradine drug; chitosan; electrospun nanofibers; halloysite nanoclay; PVA
Atif Islam, Institute of Polymer and Textile Engineering, University of the Punjab, Lahore, Pakistan, E-mail: and Samar Z. Alshawwa, Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Alriyadh, Saudi Arabia, E-mail:

Funding source: Princess Nourah bint Abdulrahman University

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This research was funded by the Deanship of Scientific Research at Princess Nourah bint Abdulrahman University through the Fast-track Research Funding Program.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2021-06-11
Accepted: 2021-08-28
Published Online: 2021-09-21
Published in Print: 2022-02-23

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Original Papers
  3. Hydrothermal synthesis, characterization and photocatalytic activity of Mg doped MoS2
  4. Insight role of TiO2 to improve the photocatalytic performance of WO3 nanostructures for the efficient degradation of ciprofloxacin
  5. Highly photosensitized Mg4 Si6O15 (OH)2·6H2O@guar gum nanofibers for the removal of methylene blue under solar light irradiation
  6. Swelling and kinetic investigations of basic blue-3 sorption by polyacrylamide/Gum Arabic hybrid hydrogel in aqueous medium
  7. Green corrosion inhibitor: Cymbopogon schoenanthus extract in an acid cleaning solution for aluminum brass
  8. Cephradine drug release using electrospun chitosan nanofibers incorporated with halloysite nanoclay
  9. Exploring the charge injection aptitude in pyrazol and oxazole derivatives by the first-principles approach
  10. Preparation and characterization of vitamin D microemulsions using two-component surface-active stabilizer system
  11. Vildagliptin plasticized hydrogel film in the control of ocular inflammation after topical application: study of hydration and erosion behaviour
https://doi.org/10.1515/zpch-2021-3072
Schlagwörter für diesen Artikel
cephradine drug; chitosan; electrospun nanofibers; halloysite nanoclay; PVA

Artikel in diesem Heft

  1. Frontmatter
  2. Original Papers
  3. Hydrothermal synthesis, characterization and photocatalytic activity of Mg doped MoS2
  4. Insight role of TiO2 to improve the photocatalytic performance of WO3 nanostructures for the efficient degradation of ciprofloxacin
  5. Highly photosensitized Mg4 Si6O15 (OH)2·6H2O@guar gum nanofibers for the removal of methylene blue under solar light irradiation
  6. Swelling and kinetic investigations of basic blue-3 sorption by polyacrylamide/Gum Arabic hybrid hydrogel in aqueous medium
  7. Green corrosion inhibitor: Cymbopogon schoenanthus extract in an acid cleaning solution for aluminum brass
  8. Cephradine drug release using electrospun chitosan nanofibers incorporated with halloysite nanoclay
  9. Exploring the charge injection aptitude in pyrazol and oxazole derivatives by the first-principles approach
  10. Preparation and characterization of vitamin D microemulsions using two-component surface-active stabilizer system
  11. Vildagliptin plasticized hydrogel film in the control of ocular inflammation after topical application: study of hydration and erosion behaviour
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