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Decomposition Kinetics of Levofloxacin: Drug-Excipient Interaction

  • Jan Nisar EMAIL logo , Mudassir Iqbal , Munawar Iqbal , Afzal Shah , Mohammad Salim Akhter , Sirajuddin , Rafaqat Ali Khan , Israr Uddin , Luqman Ali Shah and Muhammad Sufaid Khan
Published/Copyright: March 20, 2019
Zeitschrift für Physikalische Chemie
From the journal Zeitschrift für Physikalische Chemie Volume 234 Issue 1

Abstract

The present study is focused on the thermal decomposition of Levofloxacin in the absence and presence of different excipients (sodium starch glycolate, magnesium stearate, microcrystalline cellulose and lactose using Thermogravimetry (TG). Fourier Transform Infra Red Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) were used to study the possible drug – excipient interaction. It has been shown that the interaction of the first three excipients (sodium starch glycolate, magnesium stearate, and microcrystalline cellulose) with Levofloxacin is physical in nature. Lactose was shown to decrease the degradation temperature to a maximum extent. This indicates a strong chemical interaction between the drug and lactose. The activation energies in the former case were found almost similar but deviated considerably in the latter case.

Keywords: drug-excipient interaction; excipients; kinetic analysis; levofloxacin; thermal decomposition

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Received: 2018-07-31
Accepted: 2019-02-21
Published Online: 2019-03-20
Published in Print: 2020-01-28

©2020 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/zpch-2018-1273
Keywords for this article
drug-excipient interaction; excipients; kinetic analysis; levofloxacin; thermal decomposition

Articles in the same Issue

  1. Frontmatter
  2. The Maximum of Minimal Conductivity in Aqueous Electrolytes
  3. The Effect of Low Weight Percent Multiwalled Carbon Nanotubes on the Dielectric Properties of Non-Conducting Polymer/Ceramic Nanocomposites for Energy Storage Materials
  4. Synthesis, Characterization and Electrical Conductivity of Silver Doped Polyvinyl Acetate/Graphene Nanocomposites: A Novel Humidity Sensor
  5. Preparation, Physical Characterization and Adsorption Properties of Synthesized Co–Ni–Cr Nanocomposites for Highly Effective Removal of Nitrate: Isotherms, Kinetics and Thermodynamic Studies
  6. New Heterocyclic Derivative to Stop Carbon Steel Corrosion
  7. Investigating of Erosion-Corrosion Behavior of Carbon Steel in Egyptian Crude Oil-Water Mixture Using Electrochemical Method
  8. Structural, Vibrational and UV/Vis Studies of Adamantane-Containing Triazole Thiones by Spectral, DFT and Multi-reference ab initio Methods
  9. The Effect of Grain Size and Shape on Sliding Friction of Wet Granular Media
  10. Decomposition Kinetics of Levofloxacin: Drug-Excipient Interaction
  11. ZnO/UV/H2O2 Based Advanced Oxidation of Disperse Red Dye
  12. An Efficient Ultrasonic-Assisted Synthesis and Nonlinear Optical Property of Donor (D) -π-Acceptor (A) Chalcone (DDFP)
  13. Synthesized and Photocatalytic Mechanism of the NiO Supported YMnO3 Nanoparticles for Photocatalytic Degradation of the Methyl Orange Dye
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