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Temperature-Enhanced Follicular Penetration of Thermoresponsive Nanogels

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Published/Copyright: May 3, 2018
Zeitschrift für Physikalische Chemie
From the journal Zeitschrift für Physikalische Chemie Volume 232 Issue 5-6

Abstract

Hair follicles can serve as an effective reservoir for dermal drug delivery upon the topical application of particulate substances. Here, the follicular penetration of an indodicarbocyanine-labelled thermoresponsive nanogel (189 nm) having a cloud point temperature of 34°C and linked via an acid-labile linker to the model drug indocarbocyanine was investigated. In total, 227 hair follicles of porcine ear skin were examined after topical application of the thermoresponsive nanogels at room temperature (21°C), physiological skin surface temperature (32°C) and core body temperature (37°C) for the follicular penetration depths of indodicarbocyanine and indocarbocyanine using confocal laser scanning microscopy. The results showed a significantly increased mean follicular penetration of the carrier to a depth of 298.8±85.8 μm after incubation at 37°C compared to samples incubated at 21°C and 32°C with mean follicular penetration depths of 202.7±81.7 μm and 219.4±52.9 μm, respectively (p<0.001). Possibly structural changes in the thermoresponsive nanogel induced by the increased incubation temperature led to an enhancement of follicular penetration. Therefore, thermoresponsive nanogels may be suitable for the temperature-enhanced penetration into the hair follicles under physiological conditions.

Keywords: drug delivery; follicular penetration; penetration; skin; thermoresponsive nanogels

Dedicated to: Eckart Rühl on the occasion of his 60th birthday.

Acknowledgments

The work has been partly supported by the collaborative research center 1112 (http://www.sfb1112.de), Projects A04 and C05 of the DFG. Marcelo Calderón also acknowledges the Bundesministerium für Bildung und Forschung (BMBF) through the NanoMatFutur award (13N12561, Thermonanogele).

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Received: 2017-11-22
Accepted: 2018-4-9
Published Online: 2018-5-3
Published in Print: 2018-5-24

©2018 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Eckart Rühl zum 60. Geburtstag
  3. Effect of Moisture on Methane Permeation Through Fermenter Covering Films in Biogas Plants
  4. The Effect of Natural Osmolyte Mixtures on the Temperature-Pressure Stability of the Protein RNase A
  5. Composition, Mixing State and Water Affinity of Meteoric Smoke Analogue Nanoparticles Produced in a Non-Thermal Microwave Plasma Source
  6. Characterization of Trinuclear Oxo Bridged Cobalt Complexes in Isolation
  7. White-Light Supercontinuum Laser-Based Multiple Wavelength Excitation for TCSPC-FLIM of Cutaneous Nanocarrier Uptake
  8. Distinction of Structural Isomers of Benzenediamin and Difluorobenzene by Means of Chirped Femtosecond Laser Ionization Mass Spectrometry
  9. Intermolecular Interactions of Pyridine in Liquid Phase and Aqueous Solution Studied by Soft X-ray Absorption Spectroscopy
  10. Influence of Local Environment on Inner Shell Excitation Spectra, Studied by Electron and X-ray Spectroscopy and Spectromicroscopy
  11. Photocatalytic Iron Oxide Micro-Swimmers for Environmental Remediation
  12. Fabrication of Protein Microparticles and Microcapsules with Biomolecular Tools
  13. Catalysis by Metallic Nanoparticles in Solution: Thermosensitive Microgels as Nanoreactors
  14. Temperature-Enhanced Follicular Penetration of Thermoresponsive Nanogels
  15. Influence of Organic Ligands on the Surface Oxidation State and Magnetic Properties of Iron Oxide Particles
  16. VUV Dissociative Photoionization of Quinoline in the 7–26 eV Photon Energy Range
  17. Spin-labeling of Dexamethasone: Radical Stability vs. Temporal Resolution of EPR-Spectroscopy on Biological Samples
  18. Band Bending at the Gold (Au)/Boron Carbide-Based Semiconductor Interface
  19. Spectral Distribution of Oscillator Strength for Core-to-Valence Transitions probed by using X-ray Absorption and Total Electron Yield Modes
  20. Protease-mediated Inflammation: An In Vitro Human Keratinocyte-based Screening Tool for Anti-inflammatory Drug Nanocarrier Systems
https://doi.org/10.1515/zpch-2017-1080
Keywords for this article
drug delivery; follicular penetration; penetration; skin; thermoresponsive nanogels

Articles in the same Issue

  1. Frontmatter
  2. Eckart Rühl zum 60. Geburtstag
  3. Effect of Moisture on Methane Permeation Through Fermenter Covering Films in Biogas Plants
  4. The Effect of Natural Osmolyte Mixtures on the Temperature-Pressure Stability of the Protein RNase A
  5. Composition, Mixing State and Water Affinity of Meteoric Smoke Analogue Nanoparticles Produced in a Non-Thermal Microwave Plasma Source
  6. Characterization of Trinuclear Oxo Bridged Cobalt Complexes in Isolation
  7. White-Light Supercontinuum Laser-Based Multiple Wavelength Excitation for TCSPC-FLIM of Cutaneous Nanocarrier Uptake
  8. Distinction of Structural Isomers of Benzenediamin and Difluorobenzene by Means of Chirped Femtosecond Laser Ionization Mass Spectrometry
  9. Intermolecular Interactions of Pyridine in Liquid Phase and Aqueous Solution Studied by Soft X-ray Absorption Spectroscopy
  10. Influence of Local Environment on Inner Shell Excitation Spectra, Studied by Electron and X-ray Spectroscopy and Spectromicroscopy
  11. Photocatalytic Iron Oxide Micro-Swimmers for Environmental Remediation
  12. Fabrication of Protein Microparticles and Microcapsules with Biomolecular Tools
  13. Catalysis by Metallic Nanoparticles in Solution: Thermosensitive Microgels as Nanoreactors
  14. Temperature-Enhanced Follicular Penetration of Thermoresponsive Nanogels
  15. Influence of Organic Ligands on the Surface Oxidation State and Magnetic Properties of Iron Oxide Particles
  16. VUV Dissociative Photoionization of Quinoline in the 7–26 eV Photon Energy Range
  17. Spin-labeling of Dexamethasone: Radical Stability vs. Temporal Resolution of EPR-Spectroscopy on Biological Samples
  18. Band Bending at the Gold (Au)/Boron Carbide-Based Semiconductor Interface
  19. Spectral Distribution of Oscillator Strength for Core-to-Valence Transitions probed by using X-ray Absorption and Total Electron Yield Modes
  20. Protease-mediated Inflammation: An In Vitro Human Keratinocyte-based Screening Tool for Anti-inflammatory Drug Nanocarrier Systems
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