Solubility and Thermodynamics of 6-Phenyl-4,5-dihydropyridazin-3(2H)-one in Various (PEG 400+Water) Mixtures
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Mohd. Imran
Abstract
The aim of this study was to determine the solubility of pyridazinone derivative 6-phenyl-4,5-dihydropyridazin-3(2H)-one (PDP-6) in different “polyethylene glycol 400 (PEG 400)+water” mixtures at temperatures “T=293.2 K to 313.2 K” and pressure “p=0.1 MPa”. The solubilities of PDP-6 were determined using an isothermal method and correlated with Apelblat, van’t Hoff and Yalkowsky–Roseman models. The maximum solubilities of PDP-6 in mole fraction were obtained in neat PEG 400 (8.46×10−2 at T=313.2 K). However, the minimum one was recorded in neat water (7.50×10−7 at T=293.2 K). Apparent thermodynamic analysis showed an endothermic dissolution of PDP-6 in all (PEG 400 water) mixtures. Based on the solubility data of the current study, PDP-6 has been considered as practically insoluble in water and soluble in PEG 400.
Acknowledgement
The author is thankful to Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University for supporting this research work.
Conflict of interest: The author states that he does not have any conflict of interest associated with this manuscript.
References
1. M. Imran, N. Nayeem, Orien. J. Chem. 32 (2016) 267.10.13005/ojc/320129Search in Google Scholar
2. M. Imran, Abida, Trop. J. Pharm. Sci. 15 (2016) 1579.10.4314/tjpr.v15i7.30Search in Google Scholar
3. M. Asif, S. Anita, Ovidius Univ. Ann. Chem. 22 (2011) 98.Search in Google Scholar
4. T. D. Dobariya, P. J. Multani, Int. J. ChemTech. Res. 5 (2013) 2154.Search in Google Scholar
5. M. S. Nieminen, S. Fruhwald, L. M. A. Heunks, P. K. Suominen, A. C. Gordon, M. Kivikko, P. Pollesello, Heart Lung Vessels 5 (2013) 227.Search in Google Scholar
6. D. Kumar, R. Carron, D. De La Calle, D. P. Jindal, R. Bansal, Acta Pharm. 58 (2008) 393.10.2478/v1007-008-0021-4Search in Google Scholar PubMed
7. R. Bansal, S. Thota, Med. Chem. Res. 22 (2013) 2539.10.1007/s00044-012-0261-1Search in Google Scholar
8. F. Shakeel, M. Imran, Abida, N. Haq, F. K. Alanazi, I. A. Alsarra, J. Mol. Liq. 230 (2017) 511.10.1016/j.molliq.2017.01.077Search in Google Scholar
9. M. Imran, N. Haq, Abida, F. K. Alanazi, I. A. Alsarra, F. Shakeel, J. Mol. Liq. 238 (2017) 455.10.1016/j.molliq.2017.05.032Search in Google Scholar
10. F. H. Pirhayati, A. Shayanfar, E. Rahimpour, M. Brazegar-Jalali, F. Martinez, A. Jouyban, J. Mol. Liq. 240 (2017) 268.10.1016/j.molliq.2017.05.057Search in Google Scholar
11. A. Fathi-Azarbayjani, M. Abbasi, J. Vaez-Gharamaleki, A. Jouyban, J. Mol. Liq. 215 (2016) 339.10.1016/j.molliq.2015.12.005Search in Google Scholar
12. S. Soltanpour, A. Jouyban, J. Mol. Liq. 180 (2013) 1.10.1016/j.molliq.2012.12.029Search in Google Scholar
13. A. Jouyban, F. Martinez, V. Panahi-Azar, Fluid Phase Equilib. 368 (2014) 58.10.1016/j.fluid.2014.01.044Search in Google Scholar
14. G. T. Castro, M. A. Flippa, C. M. Peralta, M. V. Davin, M. C. Almandoz, E. I. Gassul, Z. Phys. Chem. 232 (2018) 257.10.1515/zpch-2017-0946Search in Google Scholar
15. Z. Yaseen, J. Aslam, A. A. Dar, Kabir-ud-Din, Z. Phys. Chem. 227 (2013) 459.10.1524/zpch.2013.0389Search in Google Scholar
16. A. Dumbrava, D. Berger, G. Prodan, F. Moscalu, A. Diacon, Z. Phys. Chem. 232 (2018) 61.10.1515/zpch-2017-0005Search in Google Scholar
17. B. Kuttich, A. Matt, A. Weber, A.-K. Grefe, L. Vietze, B. Stühn, Z. Phys. Chem. 232 (2018) 1089.10.1515/zpch-2017-1018Search in Google Scholar
18. D. M. Jimenez, Z. J. Cardenas, F. Martinez, J. Mol. Liq. 216 (2016) 239.10.1016/j.molliq.2015.12.114Search in Google Scholar
19. F. Shakeel, M. K. Anwer, Drug. Dev. Ind. Pharm. 41 (2015) 1819.10.3109/03639045.2015.1009914Search in Google Scholar PubMed
20. Z. J. Cardenas, D.M. Jimenez, F. Martinez, J. Mol. Liq. 211 (2015) 233.10.1016/j.molliq.2015.07.013Search in Google Scholar
21. S. Soltanpour, V. Panahi-Azar, A. Taheri, Z. Bastami, A. Jouyban, J. Sol. Chem. 42 (2013) 2281.10.1007/s10953-013-0106-7Search in Google Scholar
22. F. Shakeel, M. A. Bhat, N. Haq, A. Fathi-Azarbayjani, A. Jouyban, J. Mol. Liq. 229 (2017) 241.10.1016/j.molliq.2016.12.067Search in Google Scholar
23. F. Shakeel, N. Haq, F. K. Alanazi, I. A. Alsarra, J. Mol. Liq. 219 (2016) 439.10.1016/j.molliq.2016.03.058Search in Google Scholar
24. T. Higuchi, K. A. Connors, Adv. Anal. Chem. Inst. 4 (1965) 117.10.2534/jjasnaoe1952.1965.178Search in Google Scholar
25. F. Shakeel, N. Haq, F. K. Alanazi, I. A. Alsarra, J. Mol. Liq. 213 (2016) 221.10.1016/j.molliq.2015.10.057Search in Google Scholar
26. F. Shakeel, N. Haq, F. K. Alanazi, I. A. Alsarra, J. Chem. Thermodyn. 82 (2015) 156.10.1016/j.jct.2014.11.008Search in Google Scholar
27. A. Apelblat, E. Manzurola, J. Chem. Thermodyn. 31 (1999) 85.10.1006/jcht.1998.0424Search in Google Scholar
28. E. Manzurola, A. Apelblat, J. Chem. Thermodyn. 34 (2002) 1127.10.1006/jcht.2002.0975Search in Google Scholar
29. S.H. Yalkowsky, T. J. Roseman, Solubilization of Drugs by Cosolvents, In Techniques of Solubilization of Drugs, S. H. Yalkowsky, Ed. Marcel Dekker Inc, New York (1981), pp. 91–134.Search in Google Scholar
30. M. A. Ruidiaz, D. R. Delgado, F. Martínez, Y. Marcus, Fluid Phase Equilib. 299 (2010) 259.10.1016/j.fluid.2010.09.027Search in Google Scholar
31. A. R. Holguín, G. A. Rodríguez, D. M. Cristancho, D. R. Delgado, F. Martínez, Fluid Phase Equilib. 314 (2012) 134.10.1016/j.fluid.2011.11.001Search in Google Scholar
32. R. R. Krug, W.G. Hunter, R.A. Grieger, J. Phys. Chem. 80 (1976) 2341.10.1021/j100562a007Search in Google Scholar
33. F. Shakeel, N. Haq, N. A. Siddiqui, F. K. Alanazi, I. A. Alsarra, Food Chem. 188 (2015) 57.10.1016/j.foodchem.2015.04.113Search in Google Scholar PubMed
©2019 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
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- The Differential Spectroscopic Investigation of Partitioning of Reactive Dyes in Micellar Media of Cationic Surfactant, Cetyl Trimethylammonium Bromide (CTAB)
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- Adsorption and Computational Studies for Evaluating the Behavior of Silicon Based Compounds as Novel Corrosion Inhibitors of Carbon Steel Surfaces in Acidic Media
- Volumetric, Viscosity and Conductance Studies of Solute–Solute and Solute–Solvent Interactions of Some Alkali Metal Chlorides in Aqueous Citric Acid at Different Temperatures
- Solubility and Thermodynamics of 6-Phenyl-4,5-dihydropyridazin-3(2H)-one in Various (PEG 400+Water) Mixtures
- Micellar Supported Ultrafiltration of Malachite Green: Experimental Verification of Theoretical Approach
- Experimental and Theoretical Study on the Interaction of P-Aminophenol Hydrochloride with H2O
Articles in the same Issue
- Frontmatter
- Study of Intermolecular Interactions of CTAB with Amino Acids at Different Temperatures: A Multi Technique Approach
- The Differential Spectroscopic Investigation of Partitioning of Reactive Dyes in Micellar Media of Cationic Surfactant, Cetyl Trimethylammonium Bromide (CTAB)
- Extraction of Heavy Metals from Aqueous Medium by Husk Biomass: Adsorption Isotherm, Kinetic and Thermodynamic study
- Adsorption and Computational Studies for Evaluating the Behavior of Silicon Based Compounds as Novel Corrosion Inhibitors of Carbon Steel Surfaces in Acidic Media
- Volumetric, Viscosity and Conductance Studies of Solute–Solute and Solute–Solvent Interactions of Some Alkali Metal Chlorides in Aqueous Citric Acid at Different Temperatures
- Solubility and Thermodynamics of 6-Phenyl-4,5-dihydropyridazin-3(2H)-one in Various (PEG 400+Water) Mixtures
- Micellar Supported Ultrafiltration of Malachite Green: Experimental Verification of Theoretical Approach
- Experimental and Theoretical Study on the Interaction of P-Aminophenol Hydrochloride with H2O
