Abstract
Psoriasis is a chronic autoimmune skin disease with a worldwide prevalence of 1–3 % results from uncontrolled proliferation of keratinocytes and affects millions of people. While there are various treatment options available, some of them may come with potential side effects and limitations. Recent research has shown that using bioactive compounds that originate from natural sources with a lower risk of side effects are relatively useful in safe management psoriasis. Bioactive compounds are molecules that are naturally available with potential therapeutic efficacy. Some of bioactive compounds that have shown promising results in the management of psoriasis include curcumin, resveratrol, quercetin, epigallocatechin-3-gallate, etc., possess anti-inflammatory, antioxidant, immunomodulatory, and anti-proliferative properties, with capabilities to suppress overall pathogenesis of psoriasis. Moreover, these bioactive compounds are generally considered as safe and are well-tolerated, making them potential options for long-term use in the management of various conditions linked with psoriasis. In addition, these natural products may also offer a more holistic approach to treat the disease, which is appealing to many patients. This review explores the bioactive compounds in mitigation of psoriasis either in native or incorporated within novel drug delivery. Moreover, recent clinical findings in relation to natural product usage have been also explored.
Abbreviations
- DC
-
Dendritic cells
- IL
-
Interleukin
- Tregs
-
Regulatory T cells
- IFN
-
Interferon
- TNF-α
-
Tumor necrosis factor-α
- APCs
-
Antigen-presenting cells
- NADH
-
Nicotinamide adenine dinucleotide
- PSE
-
Psoriatic skin equivalent
- IMQ
-
Imiquimod
- PASI
-
Psoriasis Area and Severity Index
Acknowledgments
This work was partially supported by CMU Proactive Researcher Scheme (2023), Chiang Mai University for Sudarshan Singh. Moreover, authors are grateful to Ganpat University for providing necessary facilities. In addition, Dr. Prajapati would like to extend his sincere appreciation to the Faculty of Pharmacy, Silpakorn University, Thailand, for their generous support that enabled the completion of this work.
-
Research ethics: Not applicable.
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Informed consent: Third party material such as figures has been reproduced with permission from concern publication house.
-
Author contributions: Conceptualization, SS and BGP; methodology, PP, KG, AB, and DUK; software, KG, AB, and DUK; validation, SS and BGP; investigation, KG, AB, and DUK; resources, SS; data curation, SS; writing original draft preparation, KG, AB, and DUK; writing review and editing, SS; visualization, BGP; supervision, BGP and SS; project administration, PP, SS, and BGP. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Use of Large Language Models, AI and Machine Learning Tools: None declared.
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Conflict of interest: All other authors state no conflict of interest.
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Research funding: None declared.
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Data availability: Data can be made available on request to corropondening authors.
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© 2024 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Review Articles
- Phyto-pharmaceuticals as a safe and potential alternative in management of psoriasis: a review
- Latest developments in biomaterial interfaces and drug delivery: challenges, innovations, and future outlook
- Antidiabetic phytochemicals: an overview of medicinal plants and their bioactive compounds in diabetes mellitus treatment
- Pharmacological and toxicological profile of the Stachys lavandulifolia Vahl: a comprehensive review
- Research Articles
- Essential oil composition, in vitro antidiabetic, cytotoxicity, antimicrobial, antioxidant activity, and in silico molecular modeling analysis of secondary metabolites from Justicia schimperiana
- French marigold (Tagetes patula) flavonoid extract-based priming ameliorates initial drought stress on Oryza sativa var indica, cultivar Satabdi (IET4786): a sustainable approach to avoid initial drought stress
- Assessing the molecular interaction between a COVID-19 drug, nirmatrelvir, and human serum albumin: calorimetric, spectroscopic, and microscopic investigations
- Insight into in vitro thymidine phosphorylase and in silico molecular docking studies: identification of hybrid thiazole bearing Schiff base derivatives
- In vivo evaluation of the antinociceptive effects of novel methylsulfonyl group-containing compounds
Articles in the same Issue
- Frontmatter
- Review Articles
- Phyto-pharmaceuticals as a safe and potential alternative in management of psoriasis: a review
- Latest developments in biomaterial interfaces and drug delivery: challenges, innovations, and future outlook
- Antidiabetic phytochemicals: an overview of medicinal plants and their bioactive compounds in diabetes mellitus treatment
- Pharmacological and toxicological profile of the Stachys lavandulifolia Vahl: a comprehensive review
- Research Articles
- Essential oil composition, in vitro antidiabetic, cytotoxicity, antimicrobial, antioxidant activity, and in silico molecular modeling analysis of secondary metabolites from Justicia schimperiana
- French marigold (Tagetes patula) flavonoid extract-based priming ameliorates initial drought stress on Oryza sativa var indica, cultivar Satabdi (IET4786): a sustainable approach to avoid initial drought stress
- Assessing the molecular interaction between a COVID-19 drug, nirmatrelvir, and human serum albumin: calorimetric, spectroscopic, and microscopic investigations
- Insight into in vitro thymidine phosphorylase and in silico molecular docking studies: identification of hybrid thiazole bearing Schiff base derivatives
- In vivo evaluation of the antinociceptive effects of novel methylsulfonyl group-containing compounds