Inhibition of pro-inflammatory cytokines by homalolide A and homalomenol A isolated from rhizomes of Homalomena pendula
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Linh Thuy Khanh Nguyen
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Hien Minh Nguyen
Abstract
Inflammation, a natural process of the innate immune system, involves elevated levels of various proinflammatory mediators, such as, nitric oxide (NO) and prostaglandin (PGE2), cytokines such as interleukin 6 (IL-6), interleukin 10 (IL-10) and tumor necrosis factor alpha (TNF-α), and enzymes including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). This study investigated the anti-inflammatory effects of homalolide A (1) and homalomenol A (2), two sesquiterpenoids isolated from the rhizome of Homalomena pendula, on lipopolysaccharide (LPS)- stimulated macrophage cells. The results demonstrated that both 1 and 2 dose-dependently inhibited the production of PGE2, TNF-α and IL-6 in RAW 264.7 macrophages. Furthermore, 2 also stimulated IL-10 production in RAW 264.7 cells. Consistent with these findings, these compounds suppressed the LPS-stimulated protein levels of iNOS and COX-2 in RAW 264.7 cells. These results suggested that 1 and 2 could be effective candidates for ameliorating inflammatory-associated complications.
Funding source: Vingroup Innovation Foundation (Nguyen Khanh Thuy Linh was funded by the Master, PhD Scholarship Programme of Vingroup Innovation Foundation (VINIF)) and Hue University under the Core Research Program
Award Identifier / Grant number: NCM.DHH.2023.02
Award Identifier / Grant number: VINIF.2023.TS.059
Acknowledgments
This research was supported by Vingroup Innovation Foundation (Nguyen Khanh Thuy Linh was funded by the Master, PhD Scholarship Programme of Vingroup Innovation Foundation (VINIF), code VINIF.2023.TS.059). The authors also acknowledge the partial support of Hue University under the Core Research Program, Grant No. NCM.DHH.2023.02.
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Research ethics: Not applicable.
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Informed consent: Not applicable.
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Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Use of Large Language Models, AI and Machine Learning Tools: None declared.
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Conflict of interest: All other authors state no conflict of interest.
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Research funding: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by Vingroup Innovation Foundation (Nguyen Khanh Thuy Linh was funded by the Master, PhD Scholarship Programme of Vingroup Innovation Foundation (VINIF), code VINIF.2023.TS.059). The authors also acknowledge the partial support of Hue University under the Core Research Program, Grant No. NCM.DHH.2023.02.
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Data availability: The raw data can be obtained on request from the corresponding author.
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Articles in the same Issue
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- Effect of Hibiscus sabdariffa L. leaf flavonoid-rich extract on Nrf-2 and HO-1 pathways in liver damage of streptozotocin-induced diabetic rats
- Inhibition of pro-inflammatory cytokines by homalolide A and homalomenol A isolated from rhizomes of Homalomena pendula
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Articles in the same Issue
- Frontmatter
- Review Articles
- Ethnopharmacology and current conservational status of Cordyceps sinensis
- Review perspective on advanced nutrachemicals and anterior cruciate ligament rehabilitation
- Research Articles
- Cytotoxic compounds from Viscum coloratum (Kom.) Nakai
- Effect of Hibiscus sabdariffa L. leaf flavonoid-rich extract on Nrf-2 and HO-1 pathways in liver damage of streptozotocin-induced diabetic rats
- Inhibition of pro-inflammatory cytokines by homalolide A and homalomenol A isolated from rhizomes of Homalomena pendula
- Synthesis, in vitro anti-urease, in-silico molecular docking study and ADMET predictions of piperidine and piperazine Morita-Baylis-Hillman Adducts (MBHAs)
- Molecular modeling and synthesis of novel benzimidazole-derived thiazolidinone bearing chalcone derivatives: a promising approach to develop potential anti-diabetic agents
- Determination of essential oil and phenolic compounds of Berberis vulgaris grown in Şavşat, Artvin; revealing its antioxidant and antimicrobial activities
- Essential oil of Daucus carota (L.) ssp. carota (Apiaceae) flower: chemical composition, antimicrobial potential, and insecticidal activity on Sitophilus oryzae (L.)
