Cytotoxic compounds from Viscum coloratum (Kom.) Nakai
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Bo Wen
and
Bing-You Yang
Abstract
Two new compounds (1–2) and a new artificial product (3) together with fifteen known compounds (4–18) were isolated from Viscum coloratum (Kom.) Nakai. Their structures were established by analysis of their spectroscopic data including MS, 1D and 2D NMR spectra, and comparison with existing literature. All the compounds were assessed for their cytotoxic activity against 4T1 and LN229 cells (with cisplatin as the positive control), and the anti-LN229 cytotoxicity of compounds 3, 4 and 5 were greater than that of 4T1 cells.
Funding source: National Natural Science Foundation of China
Award Identifier / Grant number: U22A20370
Funding source: Heilongjiang Touyan Innovation Team Program
Award Identifier / Grant number: [2019]5
Funding source: Key Research and Development Projects of Heilongjiang Province
Award Identifier / Grant number: GA21D008
Funding source: Heilongjiang Province “Double First Class” Discipline Collaborative Innovation Achievement Construction Project
Award Identifier / Grant number: LJGXCG2022-096
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Research ethics: Not applicable.
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Informed consent: Not applicable.
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Author contributions: Bo Wen extracted, isolated and structurally analyzed compounds 1–18, and wrote manuscripts. Juan Pan guided the whole experimental process and operated the nuclear magnetic resonance instrument. Xin Meng carried out the cytotoxic experiment of compounds 1–18. Wei Guan determined its HR-ESI-MS spectrum. Zhi-Chao Hao guided cytotoxicity experiment. Hai-Xue Kang provided experimental funds. Qing-Shan Chen and Li-li Zhang contributed supervision. Yan Liu and Bing-You Yang designed the experiment and provided experimental funds. The authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Use of Large Language Models, AI and Machine Learning Tools: None declared.
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Conflict of interest: The authors state no conflict of interest.
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Research funding: This work was financially supported by the National Natural Science Foundation of China (U22A20370), Key Research and Development Projects of Heilongjiang Province (GA21D008), and Heilongjiang Touyan Innovation Team Program ([2019]5), and Heilongjiang Province “Double First Class” Discipline Collaborative Innovation Achievement Construction Project (LJGXCG2022-096).
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Data availability: The raw data can be obtained on request from the corresponding author.
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Supplementary Material
This article contains supplementary material (https://doi.org/10.1515/znc-2023-0170).
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Articles in the same Issue
- Frontmatter
- Review Articles
- Ethnopharmacology and current conservational status of Cordyceps sinensis
- Review perspective on advanced nutrachemicals and anterior cruciate ligament rehabilitation
- Research Articles
- Cytotoxic compounds from Viscum coloratum (Kom.) Nakai
- Effect of Hibiscus sabdariffa L. leaf flavonoid-rich extract on Nrf-2 and HO-1 pathways in liver damage of streptozotocin-induced diabetic rats
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- Molecular modeling and synthesis of novel benzimidazole-derived thiazolidinone bearing chalcone derivatives: a promising approach to develop potential anti-diabetic agents
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