Design, synthesis and apoptotic effects of novel benzoxazole compounds
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Betül Kaya
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Leyla Yurttaş
Abstract
A series of new benzoxazole-hydrazone and benzoxazole-1,3,4-oxadiazole derivatives have been designed, synthesized and evaluated as cytotoxic agents toward human A549 lung cancer cells. Compounds 3d, 3e, 5b, 5c, 5d and 5e were the most potent compounds with IC50 values of <3.9, 10.33, 11.6, 5.00, <3.9 and 4.5 μg/mL, respectively, which are higher than reference drug cisplatin (IC50 = 19.00 μg/mL). The flow cytometry-based apoptosis detection assay was performed to determine their effects on apoptosis in A549 cells. All tested compounds induced apoptosis in A549 cell line.
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Research ethics: Not applicable.
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Author contributions: B.K. and L.Y. contributed to the conception and design of the study, synthesized the designed compounds and enlightened their structures. G.A.Ç. and M.O.A. performed the biological activities of the synthesized compounds. B.K. and L.Y. wrote the manuscript. All authors contributed to manuscript revision, read, and approved the submitted version.
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Competing interests: The authors state no conflict of interest.
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Research funding: None declared.
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Data availability: Not applicable.
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Supplementary Material
This article contains supplementary material (https://doi.org/10.1515/znc-2023-0099).
© 2023 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
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- Terpenoid compounds from the fruits of Solanum virginianum
- Design, synthesis, and biological activity studies of carbonic anhydrase inhibitors
- Design, synthesis and apoptotic effects of novel benzoxazole compounds
- Corrigendum
- Corrigendum to: Proximate analysis and fatty acid, mineral and soluble carbohydrate profiles of some brown macroalgae collected from Türkiye coasts
Artikel in diesem Heft
- Frontmatter
- Research Articles
- Crystal structure of phloridzin and its distribution changes in flowering and fruiting stage of Malus rockii
- Evaluation of maceration, microwave, ultrasound-assisted extraction methods on free, esterified and bound phenolic profile and antioxidant activity of black rice
- Dietary flavonoid myricetin 3-O-galactoside suppresses α-melanocyte stimulating hormone-induced melanogenesis in B16F10 melanoma cells by regulating PKA and ERK1/2 activation
- A new alkaloid from Portulaca oleracea L. with its anti-inflammatory activity
- Terpenoid compounds from the fruits of Solanum virginianum
- Design, synthesis, and biological activity studies of carbonic anhydrase inhibitors
- Design, synthesis and apoptotic effects of novel benzoxazole compounds
- Corrigendum
- Corrigendum to: Proximate analysis and fatty acid, mineral and soluble carbohydrate profiles of some brown macroalgae collected from Türkiye coasts
