Terpenoid compounds from the fruits of Solanum virginianum
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Yan Liu
and
Bing-You Yang
Abstract
Eleven compounds were isolated and identified from ethanolic extracts of Solanum virginianum fruits, including two new compounds (1–2) and nine known compounds (3–11). Their structures were determined to be melongenaterpene C15-O-β-D-glucopyranoside (1), (9Z)-3,7,11,15-tetramethyl -hexadeca-1,6,10-triene-3,5,14,15-tetraol-5-O-β-D-glucopyranoside (2), actini-dioionoside A (3), byzantionoside B (4), citroside A (5), 7Z-roseoside (6), matenoside A (7), megastigmane (8), dihydrophaseic acid 3′-O-β-D-glucopyranoside (9), taraxerol (10), and huzhangoside C (11). In this paper, NMR spectroscopy was used to study the structures of the compounds, comparing their data with those in the literature. In addition, the potential anti-inflammatory activity of the compounds was also evaluated using the RAW264.7 cell inflammation model induced by lipopolysaccharide (LPS). The terpenoids showed no significant anti-inflammatory activity.
Funding source: Key Research and Development Projects of Heilongjiang Province
Award Identifier / Grant number: GA21D008
Funding source: Heilongjiang Touyan Innovation Team Program
Award Identifier / Grant number: [2019] No.5
Funding source: Heilongjiang Province "Double first-class" discipline collaborative innovation achievement construction project
Award Identifier / Grant number: LJGXCG2022-096
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Research ethics: Not applicable.
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Author contributions: Yan Liu performed the whole experiment process as a guide, performed the extraction, isolation, structural elucidation of compounds 1–11. Shuang Liu wrote the manuscript. Zhen-Peng Xu and Si-Yi Wang assayed the anti-inflammatory activity of compounds 1–11. Yi-Kai Jiang revised the article and improved the English spelling. Wei Guan measured the HR-ESI-MS spectra. Juan Pan operated the NMR instrument. Hai-Xue Kuang and Bing-You Yang designed the experiments and provided funding for experiments. The authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: The authors state no conflict of interest.
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Research funding: This work was financed by the Development Projects of Heilongjiang Province (GA21D008), Heilongjiang Touyan Innovation Team Program and Key Research ([2019] No.5) and Heilongjiang Province “Double first-class” discipline collaborative innovation achievement construction project (LJGXCG2022-096).
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Data availability: The raw data can be obtained on request from the corresponding author.
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Supplementary Material
This article contains supplementary material (https://doi.org/10.1515/znc-2023-0028).
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- Dietary flavonoid myricetin 3-O-galactoside suppresses α-melanocyte stimulating hormone-induced melanogenesis in B16F10 melanoma cells by regulating PKA and ERK1/2 activation
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- Design, synthesis, and biological activity studies of carbonic anhydrase inhibitors
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