Chemical composition and anticholinesterase activity of Lepisanthes rubiginosa (Roxb.) Leenh. essential oil
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Wan Mohd Nuzul Hakimi Wan Salleh
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Nurunajah Ab Ghani
und
Abu-Baker M. Abdel-Aal
Abstract
Essential oils obtained from medicinal plants show high therapeutic potential against several types of pathologies, including Alzheimer’s disease. The purpose of this work was to study the chemical composition and anticholinesterase inhibitory activity of the essential oil obtained from Lepisanthes rubiginosa leaves collected from Malaysia. Twenty-four components were identified using gas chromatography-flame ionization detection (GC-FID) and gas chromatography/mass spectrometry (GC-MS), which represent 99.5% of the essential oil. The identified major components include α-cadinol (40.0%), safrole (12.6%), α-amorphene (9.5%), (E)-isosafrole (5.0%), δ-cadinene (4.2%), and t-muurolol (4.1%). Anticholinesterase activity was assessed using Ellman method, and the essential oil demonstrated a moderate inhibitory activity against acetylcholinesterase (I%: 75.2%) and butyrylcholinesterase (I%: 70.2%) at conconcetration of 1000 μg/mL. The current study is the first to report chemical composition and anticholinesterase activity of the essential oil obtained from L. rubiginosa, which may have implications on the characterization, pharmaceutical, and therapeutic applications of Lepisanthes genus essential oils.
Funding source: Universiti Pendidikan Sultan Idris
Award Identifier / Grant number: Unassigned
Acknowledgments
The authors would like to thank the Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris for research facilities.
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: This study was funded by Universiti Pendidikan Sultan Idris.
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Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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© 2022 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Research Articles
- Synthesis, characterization, molecular docking, dynamics simulations, and in silico absorption, distribution, metabolism, and excretion (ADME) studies of new thiazolylhydrazone derivatives as butyrylcholinesterase inhibitors
- Study on the synthesis and structure-activity relationship of 1,2,3-triazoles against toxic activities of Bothrops jararaca venom
- In-silico elucidation reveals potential phytochemicals against angiotensin-converting enzyme 2 (ACE-2) receptor to fight coronavirus disease 2019 (COVID-19)
- Comparative study of phenolic profile, antioxidant and antimicrobial activities of aqueous extract of white and green tea
- Methylglyoxal and high glucose inhibit VEGFR2 phosphorylation at specific tyrosine residues
- Antidepressant alkaloids from the rhizomes of Corydalis decumbens
- Synthesis of new derivatives containing pyridine, investigation of MAO inhibitory activities and molecular docking studies
- Rapid Communications
- Chemical composition and bioactivities of Magnolia candollii H.Keng essential oil
- Chemical composition and anticholinesterase activity of Lepisanthes rubiginosa (Roxb.) Leenh. essential oil
Artikel in diesem Heft
- Frontmatter
- Research Articles
- Synthesis, characterization, molecular docking, dynamics simulations, and in silico absorption, distribution, metabolism, and excretion (ADME) studies of new thiazolylhydrazone derivatives as butyrylcholinesterase inhibitors
- Study on the synthesis and structure-activity relationship of 1,2,3-triazoles against toxic activities of Bothrops jararaca venom
- In-silico elucidation reveals potential phytochemicals against angiotensin-converting enzyme 2 (ACE-2) receptor to fight coronavirus disease 2019 (COVID-19)
- Comparative study of phenolic profile, antioxidant and antimicrobial activities of aqueous extract of white and green tea
- Methylglyoxal and high glucose inhibit VEGFR2 phosphorylation at specific tyrosine residues
- Antidepressant alkaloids from the rhizomes of Corydalis decumbens
- Synthesis of new derivatives containing pyridine, investigation of MAO inhibitory activities and molecular docking studies
- Rapid Communications
- Chemical composition and bioactivities of Magnolia candollii H.Keng essential oil
- Chemical composition and anticholinesterase activity of Lepisanthes rubiginosa (Roxb.) Leenh. essential oil
