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Efficient synthesis of pyrido[2,3-d]pyrimidine-7-carboxylic acids catalyzed by a TiO2/SiO2 nanocomposite in aqueous media at room temperature

  • Sepehr Sadegh-Samiei EMAIL logo and Shahrzad Abdolmohammadi
Published/Copyright: July 11, 2018
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Zeitschrift für Naturforschung B
From the journal Zeitschrift für Naturforschung B Volume 73 Issue 9

Abstract

A novel and efficient synthesis of eight 5-aryl-1,3-dimethyl-2,4-dioxo-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine-7-carboxylic acids using a TiO2/SiO2 nanocomposite with a molar ratio of 1:1 as a recyclable heterogeneous catalyst is described. The desired products, five of which are new, are formed in short reaction times (2–3 h) with high to excellent yields (94%–98%) under very moderate reaction conditions (room temperature, aqueous media).

Keywords: 1,3-dimethyl barbituric acid; 4-substituted phenylmethylidenepyruvic acids; aqueous media; pyrido[2,3-d]pyrimidine-7-carboxylic acids; recyclability of catalyst; TiO2/SiO2 nanocomposite

Acknowledgments

We thank East Tehran Branch, Islamic Azad University for its financial support.

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/znb-2018-0076).

Received: 2018-04-19
Accepted: 2018-06-14
Published Online: 2018-07-11
Published in Print: 2018-09-25

©2018 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. In this Issue
  3. NQR, NMR, and X-ray crystal structure studies of [4-C2H5-C6H4NH3]2MBr4 (M=Zn, Cd)
  4. Ein ökonomisches Verfahren zur Aufarbeitung von Reaktionsgemischen bei Lewis-Säure-induzierten elektrophilen Aromatensubstitutionen
  5. Orthoamide und Iminiumsalze, XCIVa. Kondensationsreaktion von Orthoamiden von Alkincarbonsäuren mit 2-Methyl-5-phenacyl-1,3,4-thiadiazolen
  6. Highly effectual synthesis of 4,6-diarylpyrimidin-2(1H)-ones using N,N,N′,N′-tetramethylethylenediaminium-N,N′-disulfonic acid hydrogen sulfate as a dual-functional catalyst
  7. Efficient synthesis of pyrido[2,3-d]pyrimidine-7-carboxylic acids catalyzed by a TiO2/SiO2 nanocomposite in aqueous media at room temperature
  8. Synthesis, characterization, and antitumor activity of some novel S-functionalized benzo[d]thiazole-2-thiol derivatives; regioselective coupling to the –SH group
  9. A zinc(II) coordination polymer containing single- and double-stranded helical chains: synthesis, crystal structure, and thermal and luminescence properties
  10. An unexpected lanthanum chloride carbonate hydrate: synthesis, crystal structure, vibrational spectra and thermal degradation of LaCl[CO3]·3H2O
  11. Structures of the diiodine adducts of bis(diisopropylphosphano)methane disulfide and bis(diisopropylphosphano)ethane disulfide
  12. Note
  13. Photoluminescence of Baltic amber
https://doi.org/10.1515/znb-2018-0076
Keywords for this article
1,3-dimethyl barbituric acid; 4-substituted phenylmethylidenepyruvic acids; aqueous media; pyrido[2,3-d]pyrimidine-7-carboxylic acids; recyclability of catalyst; TiO2/SiO2 nanocomposite

Articles in the same Issue

  1. Frontmatter
  2. In this Issue
  3. NQR, NMR, and X-ray crystal structure studies of [4-C2H5-C6H4NH3]2MBr4 (M=Zn, Cd)
  4. Ein ökonomisches Verfahren zur Aufarbeitung von Reaktionsgemischen bei Lewis-Säure-induzierten elektrophilen Aromatensubstitutionen
  5. Orthoamide und Iminiumsalze, XCIVa. Kondensationsreaktion von Orthoamiden von Alkincarbonsäuren mit 2-Methyl-5-phenacyl-1,3,4-thiadiazolen
  6. Highly effectual synthesis of 4,6-diarylpyrimidin-2(1H)-ones using N,N,N′,N′-tetramethylethylenediaminium-N,N′-disulfonic acid hydrogen sulfate as a dual-functional catalyst
  7. Efficient synthesis of pyrido[2,3-d]pyrimidine-7-carboxylic acids catalyzed by a TiO2/SiO2 nanocomposite in aqueous media at room temperature
  8. Synthesis, characterization, and antitumor activity of some novel S-functionalized benzo[d]thiazole-2-thiol derivatives; regioselective coupling to the –SH group
  9. A zinc(II) coordination polymer containing single- and double-stranded helical chains: synthesis, crystal structure, and thermal and luminescence properties
  10. An unexpected lanthanum chloride carbonate hydrate: synthesis, crystal structure, vibrational spectra and thermal degradation of LaCl[CO3]·3H2O
  11. Structures of the diiodine adducts of bis(diisopropylphosphano)methane disulfide and bis(diisopropylphosphano)ethane disulfide
  12. Note
  13. Photoluminescence of Baltic amber
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