Abstract
Recently, researchers have been interested in the potential connection between gut microbiota composition and various neuropsychological disorders. Dementia significantly affects the socioeconomics of families. Gut microbiota is considered as a probable factor in its pathogenesis. Multiple bacterial metabolites such as short-chain fatty acids, lipopolysaccharides, and various neurotransmitters that are responsible for the incidence and progression of dementia can be produced by gut microbiota. Various bacterial species such as Bifidobacterium breve, Akkermansia muciniphila, Streptococcus thermophilus, Escherichia coli, Blautia hydrogenotrophica, etc. are implicated in the pathogenesis of dementia. Gut microbiota can be a great target for imitating or inhibiting their metabolites as an adjunctive therapy based on their role in its pathogenesis. Therefore, some diets can prevent or decelerate dementia by altering the gut microbiota composition. Moreover, probiotics can modulate gut microbiota composition by increasing beneficial bacteria and reducing detrimental species. These therapeutic modalities are considered novel methods that are probably safe and effective. They can enhance the efficacy of traditional medications and improve cognitive function.
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Research ethics: Not applicable.
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Informed consent: Not applicable.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Use of Large Language Models, AI and Machine Learning Tools: None declared.
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Conflict of interest: The authors state no conflict of interest.
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Research funding: None declared.
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Data availability: Not applicable.
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Articles in the same Issue
- Frontmatter
- Neurological mechanism-based analysis of the role and characteristics of physical activity in the improvement of depressive symptoms
- Recognition and classification of facial expression using artificial intelligence as a key of early detection in neurological disorders
- The role of neuroinflammation in PV interneuron impairments in brain networks; implications for cognitive disorders
- The interplay between gut microbiota composition and dementia
- The essential role of cerebrospinal fluid in the brain; a comprehensive review
- Advances in repetitive transcranial magnetic stimulation in the treatment of treatment-resistant depression: a comprehensive review
Articles in the same Issue
- Frontmatter
- Neurological mechanism-based analysis of the role and characteristics of physical activity in the improvement of depressive symptoms
- Recognition and classification of facial expression using artificial intelligence as a key of early detection in neurological disorders
- The role of neuroinflammation in PV interneuron impairments in brain networks; implications for cognitive disorders
- The interplay between gut microbiota composition and dementia
- The essential role of cerebrospinal fluid in the brain; a comprehensive review
- Advances in repetitive transcranial magnetic stimulation in the treatment of treatment-resistant depression: a comprehensive review