Prevalence of sports-related spinal injury stratified by competition level and return to play guidelines
-
Brian Fiani
, Juliana Runnels
Abstract
Spinal injury is among the most severe and feared injuries an athlete may face. We present an up-to-date review of the recent literature, stratifying recommendations based on injury location (cervical, thoracic, and lumbar spine) and type, as well as, the level of competitive play (high school, collegiate, professional). A literature search was completed to identify all publications reporting return to play guidelines for athletic injuries or injury-related surgery irrespective of the study design. Publication dates were not restricted by year. Search terms used included “return to play” and “spinal injury” on National Library of Medicine (PubMed) and Google Scholar. Selection criteria for literature included axial spine injury guidelines for athletic participation post-injury or post-surgery. Literature found from the search criteria was sorted based on level of competition and location of axial spine injury involved. It was found that professional athletes are more likely to suffer severe spinal injuries, require surgery, and necessitate a longer return to play (RTP), with high school and college athletes usually returning to play within days or weeks. Injuries occur mainly within contact sports and concordance exists between initial and subsequent spinal injuries. Adequate rest, rehabilitation, and protective equipment alongside the education of athletes and coaches are recommended. In conclusion, a multidisciplinary approach to patient management is required with consideration for the emotional, social, and perhaps financial impact that spinal injury may have upon the athlete. Consensus from the literature states that in order for an athlete to safely return to play, that athlete should not be actively suffering from pain, should have a full range of motion, and complete return of their strength in the absence of neurological deficit.
Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
References
Abla, A.A., Maroon, J.C., Lochhead, R., Sonntag, V.K., Maroon, A., and Field, M. (2011). Return to golf after spine surgery. J. Neurosurg. Spine 14: 23–30, https://doi.org/10.3171/2010.9.SPINE10160.Search in Google Scholar
Ahearn, B.M., Starr, H.M., and Seiler, J.G. (2019). Traumatic brachial plexopathy in athletes: current concepts for diagnosis and management of stingers. J. Am. Acad. Orthop. Surg. 27: 677–684, https://doi.org/10.5435/JAAOS-D-17-00746.Search in Google Scholar
Albers, C.E., and Benneker, L.M. (2019). Sports injuries of the thoracic and lumbar spine. Lumbar spine online textbook. Section 17, Chapter 8, Available at: http://www.wheelessonline.com/ISSLS/section-17-chapter-8-sports-injuries-of-the-thoracic-and-lumbar-spine.Search in Google Scholar
Alizo, G., Sciarretta, J.D., Gibson, S., Muertos, K., Holmes, S., Denittis, F., Cheatle, J., Davis, J., and Pepe, A. (2018). Multidisciplinary team approach to traumatic spinal cord injuries: a single institution’s quality improvement project. Eur. J. Trauma Emerg. Surg. 44: 245–250, https://doi.org/10.1007/s00068-017-0776-8.Search in Google Scholar
Alsobrook, J. and Clugston, J.R. (2008). Return to play after surgery of the lumbar spine. Curr. Sports Med. Rep. 7: 45–48, https://doi.org/10.1097/01.CSMR.0000308666.15064.48.Search in Google Scholar
Andrews, J., Jones, A., Davies, P.R., Howes, J., and Ahuja, S. (2008). Is return to professional rugby union likely after anterior cervical spinal surgery? J Bone Joint Surg. Br. 90: 619–621, https://doi.org/10.1302/0301-620X.90B5.20546.10.1302/0301-620X.90B5.20546Search in Google Scholar PubMed
ASIA (2016). International standards for neurological classification of spinal cord injury. Richmond, VA: American Spinal Injury Association.Search in Google Scholar
ATLS, Subcommittee (2013). Advanced trauma life support (ATLS®): the ninth edition. J. Trauma Acute Care Surg. 74: 1363–1366., https://doi.org/10.1097/TA.0b013e31828b82f5.Search in Google Scholar
Aval, S.M., Durand, P.Jr., and Shankwiler, J.A. (2007). Neurovascular injuries to the athlete’s shoulder: part I. J. Am. Acad. Orthop. Surg. 15: 249–256, https://doi.org/10.5435/00124635-200704000-00008.Search in Google Scholar
Ball, J.R., Harris, C.B., Lee, J., and Vives, M.J. (2019). Lumbar spine injuries in sports: review of the literature and current treatment recommendations. Sports Med. Open 5: 26.10.1186/s40798-019-0199-7Search in Google Scholar PubMed PubMed Central
Boden, B.P. and Jarvis, C.G. (2008). Spinal injuries in sports. Neurol. Clin. 26: 63–78, https://doi.org/10.1016/j.pmr.2008.10.014.Search in Google Scholar
Burnett, M.G. and Sonntag, V.K. (2006). Return to contact sports after spinal surgery. Neurosurg. Focus 21: E5, https://doi.org/10.3171/foc.2006.21.4.6.Search in Google Scholar
Byrnes, M., Beilby, J., Ray, P., McLennan, R., Ker, J., and Schug, S. (2012). Patient-focused goal planning process and outcome after spinal cord injury rehabilitation: quantitative and qualitative audit. Clin. Rehabil. 26: 1141–1149https://doi.org/10.1177/269215512442669.10.1177/0269215512442669Search in Google Scholar PubMed
Cantella, D. (1999). Sports-related spinal cord injuries. Crit. Care Nurs. Q. 22: 14–19.10.1097/00002727-199908000-00004Search in Google Scholar PubMed
Cantu, R.C., Li, Y.M., Abdulhamid, M., and Chin, L.S. (2013). Return to play after cervical spine injury in sports. Curr. Sports Med. Rep. 12: 14–17, https://doi.org/10.1249/JSR.0b013e31827dc1fb.Search in Google Scholar
Cantu, R.C. and Mueller, F.O. (2000). Catastrophic football injuries: 1977-1998. Neurosurgery 47: 673-5, discussion: 75–77, https://doi.org/10.1097/00006123-200009000-00029.Search in Google Scholar
Chan, C.W., Eng, J.J., Tator, C.H., and Krassioukov, A. (2016). Epidemiology of sport-related spinal cord injuries: a systematic review, Spinal Cord Injury Research Evidence T. J Spinal Cord Med. 39: 255–264, https://doi.org/10.1080/10790268.2016.1138601.Search in Google Scholar
Chandra, J., Sheerin, F., Lopez de Heredia, L., Meagher, T., King, D., Belci, M., and Hughes, R.J. (2011). MRI in acute and subacute post-traumatic spinal cord injury: pictorial review. Spinal Cord 50: 2–7.10.1038/sc.2011.107Search in Google Scholar PubMed
Chung, A.S., Makovicka, J.L., Hassebrock, J.D., Patel, K.A., Tummala, S.V. (2019). Epidemiology of cervical injuries in NCAA football players. Spine 44: 848–854, https://doi.org/10.1097/BRS.0000000000003008.Search in Google Scholar
Clark, A.J., Auguste, K.I., and Sun, P.P. (2011). Cervical spinal stenosis and sports-related cervical cord neurapraxia. Neurosurg. Focus 31: E7, https://doi.org/10.3171/2011.7.FOCUS11173.Search in Google Scholar
da Silva, T., Mills, K., Brown, B.T., Herbert, R.D., Maher, C.G., and Hancock, M.J. (2017). Risk of recurrence of low back pain: a systematic review. J. Orthop. Sports Phys. Ther. 47: 305–313https://www.jospt.org/doi/10.2519/jospt.2017.7415.10.2519/jospt.2017.7415Search in Google Scholar PubMed
Dailey, A., Harrop, J.S., and France, J.C. (2010). High-energy contact sports and cervical spine neuropraxia injuries: what are the criteria for return to participation? Spine 35: S193–S201, https://doi.org/10.1097/BRS.0b013e3181f32db0.Search in Google Scholar
Debnath, U.K., Freeman, B.J., Gregory, P., de la Harpe, D., Kerslake, R.W., and Webb, J.K. (2003). Clinical outcome and return to sport after the surgical treatment of spondylolysis in young athletes. J. Bone Joint Surg. Br. 85: 244–249, https://doi.org/10.1302/0301-620X.85B2.13074.Search in Google Scholar
Deckey, D.G., Makovicka, J.L., Chung, A.S., Hassebrock, J.D., Patel, K.A., Tummala, S.V., Pena, A., Asprey, W., and Chhabra, A. (2020). Neck and cervical spine injuries in national college athletic association athletes: a 5-year epidemiologic study. Spine 45: 55–64, https://doi.org/10.1097/BRS.0000000000003220.Search in Google Scholar
Drakos, M.C., Domb, B., Starkey, C., Callahan, L., and Allen, A.A. (2010). Injury in the national basketball association: a 17-year overview. Sport Health 2: 284–290https://doi.org/10.1177/1941738109357303.10.1177/1941738109357303Search in Google Scholar PubMed PubMed Central
Dunn, I.F., Proctor, M.R., and Day, A.L. (2006). Lumbar spine injuries in athletes. Neurosurg. Focus 21: E4, https://doi.org/10.3171/foc.2006.21.4.5.Search in Google Scholar
Eck, J.C. and Riley, L.H.3rd (2004). Return to play after lumbar spine conditions and surgeries. Clin. Sports Med. 23: 367–379, https://doi.org/10.1016/j.csm.2004.03.002.Search in Google Scholar
Eckert, M.J. and Martin, M.J. (2017). Trauma. Surg. Clin. 97: 1031–45.10.1016/j.suc.2017.06.008Search in Google Scholar PubMed
Eddy, D., Congeni, J., and Loud, K. (2005). A review of spine injuries and return to play. Clin. J. Sport Med. 15: 453–458, https://doi.org/10.1097/01.jsm.0000186681.13416.0c.Search in Google Scholar
Elattrache, N., Fadale, P.D., and Fu, F.H. (1993). Thoracic spine fracture in a football player. A case report. Am. J. Sports Med. 21: 157–160https://doi.org/10.1177/036354659302100128.10.1177/036354659302100128Search in Google Scholar PubMed
France, J.C., Karsy, M., Harrop, J.S., and Dailey, A.T. (2016). Return to play after cervical spine injuries: a consensus of opinion. Global Spine J. 6: 792–797https://doi.org/10.1055/s-0036-1582394.10.1055/s-0036-1582394Search in Google Scholar PubMed PubMed Central
Gadia, A., Shah, K., and Nene, A. (2018). Outcomes of various treatment modalities for lumbar spinal ailments in elite athletes: a literature review. Asian Spine J. 12: 754–764https://doi.org/10.31616/asj.2018.12.4.754.10.31616/asj.2018.12.4.754Search in Google Scholar PubMed PubMed Central
Gray, B.L., Buchowski, J.M., Bumpass, D.B., Lehman, R.A.Jr., Mall, N.A., and Matava, M.J. (2013). Disc herniations in the national football league. Spine 38: 1934–1938, https://doi.org/10.1097/BRS.0b013e3182a67678.Search in Google Scholar
Greenberg, M. (2010). Spine injuries In Handbook of neurosurgery, ed.Greenberg, pp. 930–10006. New York, NY: Thieme Medical Publishersbook-chapter.Search in Google Scholar
Harcombe, H., Aldabe, D., Davie, G., Wyeth, E., and Derrett, S. (2019). Concordance between sentinel and subsequent injuries: a prospective study of injured New Zealanders. Injury 50: 301–307, https://doi.org/10.1016/j.injury.2018.10.013.Search in Google Scholar
Hassebrock, J.D., Patel, K.A., Makovicka, J.L., Chung, A.S., Tummala, S.V., Peña, A.J., Williams, K.E., Hartigan, D.E., and Chhabra, A. (2019). Lumbar spine injuries in national collegiate athletic association athletes: a 6-season epidemiological study. Orthop J. Sports Med. 7: 2325967118820046https://doi.org/10.1177/2325967118820046.10.1177/2325967118820046Search in Google Scholar PubMed PubMed Central
Haydt, R., Pheasant, S., and Lawrence, K. (2012). The incidence of low back pain in ncaa division iii female field hockey players. Int. J. Sports Phys. Ther 7: 296–305.Search in Google Scholar
Hearn, J.H., and Cross, A. (2020). Mindfulness for pain, depression, anxiety, and quality of life in people with spinal cord injury: a systematic review. BMC Neurol. 20: 32, https://doi.org/10.1186/s12883-020-1619-5.Search in Google Scholar
Heck, J.F. and Sparano, J.M. (2000). A classification system for the assessment of lumbar pain in athletes. J. Athl. Train. 35: 204–211.Search in Google Scholar
Hsu, W.K. (2011). Outcomes following nonoperative and operative treatment for cervical disc herniations in National Football League athletes. Spine 36: 800–805, https://doi.org/10.1097/BRS.0b013e3181e50651.Search in Google Scholar
Huang, P., Anissipour, A., McGee, W., and Lemak, L. (2016). Return-to-play recommendations after cervical, thoracic, and lumbar spine injuries: a comprehensive review. Sport Health 8: 19–25https://doi.org/10.1177/1941738115610753.10.1177/1941738115610753Search in Google Scholar PubMed PubMed Central
Johnson, B.K. and Comstock, R.D. (2017). Epidemiology of chest, rib, thoracic spine, and abdomen injuries among United States high school athletes, 2005/06 to 2013/14. Clin. J. Sport Med. 27: 388–393, https://doi.org/10.1097/JSM.0000000000000351.Search in Google Scholar
Kadow, T., Sowa, G., Vo, N., and Kang, J.D. (2015). Molecular basis of intervertebral disc degeneration and herniations: what are the important translational questions? Clin. Orthop. Relat. Res. 473: 1903–1912, https://doi.org/10.1007/s11999-014-3774-8.Search in Google Scholar
Kang, D.H. and Lee, S.H. (2009). Multiple spinous process fractures of the thoracic vertebrae (Clay-Shoveler’s Fracture) in a beginning Golfer: a case report. Spine 34: E534–E537, https://doi.org/10.1097/BRS.0b013e3181a983bb.Search in Google Scholar
Kraemer, W., Denegar, C., and Flanagan, S. (2009). Recovery from injury in sport: considerations in the transition from medical care to performance care. Sport Health 1: 392–395https://doi.org/10.1177/1941738109343156.10.1177/1941738109343156Search in Google Scholar PubMed PubMed Central
Leppanen, M., Aaltonen, S., Parkkari, J., Heinonen, A., and Kujala, U.M. (2014). Interventions to prevent sports related injuries: a systematic review and meta-analysis of randomised controlled trials. Sports Med. 44: 473–486, https://doi.org/10.1007/s40279-013-0136-8.Search in Google Scholar
Maffulli, N., Longo, U.G., Spiezia, F., and Denaro, V. (2010). Sports injuries in young athletes: long-term outcome and prevention strategies. Physician Sportsmed. 38: 29–34, https://doi.org/10.3810/psm.2010.06.1780.Search in Google Scholar
Mai, H.T., Chun, D.S., Schneider, A.D., Hecht, A.C., Maroon, J.C., and Hsu, W.K. (2018). The difference in clinical outcomes after anterior cervical fusion, disk replacement, and foraminotomy in professional athletes. Clin. Spine Surg. 31: E80–E84, https://doi.org/10.1097/BSD.0000000000000570.Search in Google Scholar
Makovicka, J.L., Deckey, D.G., Patel, K.A., Hassebrock, J.D., and Chung, A.S. (2019a). Epidemiology of lumbar spine injuries in men’s and women’s national collegiate athletic association basketball athletes. Orthop. J. Sports Med. 7: 2325967119879104https://doi.org/10.1177/2325967119879104.10.1177/2325967119879104Search in Google Scholar PubMed PubMed Central
Makovicka, J.L., Patel, K.A., Deckey, D.G., Hassebrock, J.D., and Chung, A.S. (2019b). Lower back injuries in national collegiate athletic association football players: a 5-season epidemiological study. Orthop. J. Sports Med. 7: 2325967119852625https://doi.org/10.1177/2325967119852625.10.1177/2325967119852625Search in Google Scholar PubMed PubMed Central
Maroon, J.C., El-Kadi, H., Abla, A.A., Wecht, D.A., and Bost, J. (2007). Cervical neurapraxia in elite athletes: evaluation and surgical treatment. 6: 356, https://doi.org/10.3171/spi.2007.6.4.13.Search in Google Scholar
McHugh-Pierzina, V.L., Zillmer, D.A., and Giangarra, C.E. (1995). Thoracic compression fracture in a basketball player. J. Athl. Train. 30: 163–164.Search in Google Scholar
Menzer, H., Gill, G.K., and Paterson, A. (2015). Thoracic spine sports-related injuries. Curr. Sports Med. Rep. 14: 34–40, https://doi.org/10.1249/JSR.0000000000000117.Search in Google Scholar
Meredith, D.S., Jones, K.J., Barnes, R., Rodeo, S.A., Cammisa, F.P., and Warren, R.F. (2013). Operative and nonoperative treatment of cervical disc herniation in National Football League athletes. Am. J. Sports Med. 41: 2054–2058. https://doi.org/10.1177/0363546513493247.Search in Google Scholar
Meron, A., McMullen, C., Laker, S.R., Currie, D., and Comstock, R.D. (2018). Epidemiology of cervical spine injuries in high school athletes over a ten-year period. Pm r 10: 365–372, https://doi.org/10.1016/j.pmrj.2017.09.003.Search in Google Scholar
Meyer, S.A., Schulte, K.R., Callaghan, J.J., Albright, J.P., and Powell, J.W. (1994). Cervical spinal stenosis and stingers in collegiate football players. Am. J. Sports Med. 22: 158–66https://doi.org/10.1177/036354659402200202.10.1177/036354659402200202Search in Google Scholar PubMed
Minhas, S.V., Kester, B.S., and Hsu, W.K. (2016). Outcomes after lumbar disc herniation in the national basketball association. Sport Health 8: 43–49https://doi.org/10.1177/1941738115608361.10.1177/1941738115608361Search in Google Scholar PubMed PubMed Central
Mizoguchi, Y., Akasaka, K., Otsudo, T., and Hall, T. (2019). Factors associated with low back pain in elite high school volleyball players. J. Phys. Ther. Sci. 31: 675–681, https://doi.org/10.1589/jpts.31.675.Search in Google Scholar
Morganti, C., Sweeney, C.A., Albanese, S.A., Burak, C., Hosea, T., and Connolly, P.J. (2001). Return to play after cervical spine injury. Spine 26: 1131–1136, https://doi.org/10.1097/00007632-200105150-00007.Search in Google Scholar
National Institute of Health (2019). Spinal cord injury information page. National Institute of Neurological Disorders and Stroke.Search in Google Scholar
National Spinal Cord Injury Statistical Center (2019). Facts and figures at a glance. Birmingham, AL: University of Alabama at Birmingham.Search in Google Scholar
Netzer, C., Valderrabano, V., and Schaeren, S. (2012). Return to sports: sport after spinal surgery. Schweizerische Zeitschrift fur Sportmedizin und Sporttraumatologie 60: 70–79.Search in Google Scholar
Petering, R.C., and Webb, C. (2011). Treatment options for low back pain in athletes. Sport Health 3: 550–555, https://doi.org/10.1177/1941738111416446.Search in Google Scholar
Purcell, L., and Micheli, L. (2009). Low back pain in young athletes. Sport Health 1: 212–222, https://doi.org/10.1177/1941738109334212.Search in Google Scholar
Quarrie, K.L., Gianotti, S.M., Hopkins, W.G., and Hume, P.A. (2007). Effect of nationwide injury prevention programme on serious spinal injuries in New Zealand rugby union: ecological study. BMJ 334: 1150, https://doi.org/10.1136/bmj.39185.605914.AE.Search in Google Scholar
Rabinstein, A.A. (2018). Traumatic spinal cord injury. Continuum: lifelong Learning in Neurology 24: 551–566, https://doi.org/10.1212/CON.0000000000000581.Search in Google Scholar
Ribaud, A., Tavares, I., Viollet, E., Julia, M., Herisson, C., and Dupeyron, A. (2013). Which physical activities and sports can be recommended to chronic low back pain patients after rehabilitation? Ann. Phys. Rehabil. Med. 56: 576–594. https://doi.org/10.1016/j.rehab.2013.08.007.Search in Google Scholar
Rosenthal, B.D., Boody, B.S., and Hsu, W.K. (2017). Return to play for athletes. Neurosurg. Clin. 28: 163–171.https://doi.org/10.1177/1941738112463347.10.1016/j.nec.2016.08.003Search in Google Scholar PubMed
Saboe, L.A., Reid, D.C., Davis, L.A., Warren, S.A., and Grace, M.G. (1991). Spine trauma and associated injuries. J. Trauma 31: 43–48, https://doi.org/10.1097/00005373-199101000-00010.Search in Google Scholar
Schroeder, G.D. and Vaccaro, A.R. (2016). Cervical spine injuries in the athlete. J. Am. Acad. Orthop. Surg. 24: e122–e33, https://doi.org/10.1055/s-2000-9825.Search in Google Scholar
Theodore, N., Ryken, T.C., Rozelle, C.J., Harrigan, M.R., and Gelb, D.E., et al. (2013). Guidelines for the management of acute cervical spine and spinal cord injuries. Neurosurgery 60: 82–91, https://doi.org/10.1227/NEU.0b013e318276edb1.Search in Google Scholar
Torg, J.S. and Ramsey-Emrhein, J.A. (1997a). Cervical spine and brachial plexus injuries: return-to-play recommendations. Physician Sportsmed. 25: 61–88, https://doi.org/10.3810/psm.1997.07.1487.Search in Google Scholar
Torg, J.S. and Ramsey-Emrhein, J.A. (1997b). Management guidelines for participation in collision activities with congenital, developmental, or postinjury lesions involving the cervical spine. Clin. J. Sport Med. 7: 273–291, https://doi.org/10.3233/BMR-1997-9206.Search in Google Scholar
Triantafillou, K.M., Lauerman, W., and Kalantar, S.B. (2012). Degenerative disease of the cervical spine and its relationship to athletes. Clin. Sports Med. 31: 509–520, https://doi.org/10.1016/j.csm.2012.03.009.Search in Google Scholar
Vaccaro, A.R., Klein, G.R., Ciccoti, M., Pfaff, W.L., Moulton, M.J., et al. (2002). Return to play criteria for the athlete with cervical spine injuries resulting in stinger and transient quadriplegia/paresis. Spine J. 2: 351–356, https://doi.org/10.1016/S1529-9430(02)00202-4.Search in Google Scholar
Wasser, J.G., Zaremski, J.L., Herman, D.C., and Vincent, H.K. (2017). Prevalence and proposed mechanisms of chronic low back pain in baseball: part i. Res. Sports Med. 25: 219–230, https://doi.org/10.1080/15438627.2017.1282361.Search in Google Scholar
Watkins, R.G. (1995). The spine in sports. pp. 688. St. Louis, MO: Mosby.Search in Google Scholar
Watkins, R.G., Chang, D., and Watkins, R.G.3rd (2018). Return to play after anterior cervical discectomy and fusion in professional athletes. Orthop. J. Sports Med. 6: 2325967118779672https://doi.org/10.1177/2325967118779672.10.1177/2325967118779672Search in Google Scholar PubMed PubMed Central
Yamaguchi, J.T. and Hsu, W.K. (2019). Intervertebral disc herniation in elite athletes. Int. Orthop. 43: 833–840.10.1007/s00264-018-4261-8Search in Google Scholar PubMed
Yamaguchi, K.T.Jr., Myung, K.S., Alonso, M.A., and Skaggs, D.L. (2012). Clay-shoveler’s fracture equivalent in children. Spine 37: E1672–E1675, https://doi.org/10.1097/BRS.0b013e318273e191.Search in Google Scholar
Zazulak, B., Cholewicki, J., and Reeves, N.P. (2008). Neuromuscular control of trunk stability: clinical implications for sports injury prevention. J. Am. Acad. Orthop. Surg. 16: 497–505.10.5435/00124635-200808000-00011Search in Google Scholar
© 2020 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Early life stress and brain plasticity: from molecular alterations to aberrant memory and behavior
- A review on preventive role of ketogenic diet (KD) in CNS disorders from the gut microbiota perspective
- Genetic parkinsonisms and cancer: a systematic review and meta-analysis
- Prevalence of sports-related spinal injury stratified by competition level and return to play guidelines
- The basal ganglia corticostriatal loops and conditional learning
- VEGF levels in patients with glioma: a systematic review and meta-analysis
- The therapeutic potential of mitochondrial transplantation for the treatment of neurodegenerative disorders
- CNS implications of COVID-19: a comprehensive review
- COVID-19 in age-related neurodegenerative diseases: is there a role for vitamin D3 as a possible therapeutic strategy?
Articles in the same Issue
- Frontmatter
- Early life stress and brain plasticity: from molecular alterations to aberrant memory and behavior
- A review on preventive role of ketogenic diet (KD) in CNS disorders from the gut microbiota perspective
- Genetic parkinsonisms and cancer: a systematic review and meta-analysis
- Prevalence of sports-related spinal injury stratified by competition level and return to play guidelines
- The basal ganglia corticostriatal loops and conditional learning
- VEGF levels in patients with glioma: a systematic review and meta-analysis
- The therapeutic potential of mitochondrial transplantation for the treatment of neurodegenerative disorders
- CNS implications of COVID-19: a comprehensive review
- COVID-19 in age-related neurodegenerative diseases: is there a role for vitamin D3 as a possible therapeutic strategy?