Abstract
Early life stress (ELS) is one of the most critical factors that could modify brain plasticity, memory and learning abilities, behavioral reactions, and emotional response in adulthood leading to development of different mental disorders. Prenatal and early postnatal periods appear to be the most sensitive periods of brain development in mammals, thereby action of various factors at these stages of brain development might result in neurodegeneration, memory impairment, and mood disorders at later periods of life. Deciphering the processes underlying aberrant neurogenesis, synaptogenesis, and cerebral angiogenesis as well as deeper understanding the effects of ELS on brain development will provide novel approaches to prevent or to cure psychiatric and neurological deficits caused by stressful conditions at the earliest stages of ontogenesis. Neuropeptide oxytocin serves as an amnesic, anti-stress, pro-angiogenic, and neurogenesis-controlling molecule contributing to dramatic changes in brain plasticity in ELS. In the current review, we summarize recent data on molecular mechanisms of ELS-driven changes in brain plasticity with the particular focus on oxytocin-mediated effects on neurogenesis and angiogenesis, memory establishment, and forgetting.
Funding source: Russian Foundation for Basic Research (RFBR)
Award Identifier / Grant number: project number 20-015-00472\20
Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: The study was funded by the Russian Foundation for Basic Research (RFBR), project number 20-015-00472\20.
Conflict of interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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© 2020 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Early life stress and brain plasticity: from molecular alterations to aberrant memory and behavior
- A review on preventive role of ketogenic diet (KD) in CNS disorders from the gut microbiota perspective
- Genetic parkinsonisms and cancer: a systematic review and meta-analysis
- Prevalence of sports-related spinal injury stratified by competition level and return to play guidelines
- The basal ganglia corticostriatal loops and conditional learning
- VEGF levels in patients with glioma: a systematic review and meta-analysis
- The therapeutic potential of mitochondrial transplantation for the treatment of neurodegenerative disorders
- CNS implications of COVID-19: a comprehensive review
- COVID-19 in age-related neurodegenerative diseases: is there a role for vitamin D3 as a possible therapeutic strategy?
Artikel in diesem Heft
- Frontmatter
- Early life stress and brain plasticity: from molecular alterations to aberrant memory and behavior
- A review on preventive role of ketogenic diet (KD) in CNS disorders from the gut microbiota perspective
- Genetic parkinsonisms and cancer: a systematic review and meta-analysis
- Prevalence of sports-related spinal injury stratified by competition level and return to play guidelines
- The basal ganglia corticostriatal loops and conditional learning
- VEGF levels in patients with glioma: a systematic review and meta-analysis
- The therapeutic potential of mitochondrial transplantation for the treatment of neurodegenerative disorders
- CNS implications of COVID-19: a comprehensive review
- COVID-19 in age-related neurodegenerative diseases: is there a role for vitamin D3 as a possible therapeutic strategy?