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The therapeutic potential of mitochondrial transplantation for the treatment of neurodegenerative disorders

  • César Espino De la Fuente-Muñoz and Clorinda Arias EMAIL logo
Published/Copyright: December 7, 2020
Become an author with De Gruyter Brill

Abstract

Mitochondrial activity is essential to support neural functions, and changes in the integrity and activity of the mitochondria can contribute to synaptic damage and neuronal death, especially in degenerative diseases associated with age, such as Alzheimer’s and Parkinson’s disease. Currently, different approaches are used to treat these conditions, and one strategy under research is mitochondrial transplantation. For years, mitochondria have been shown to be transferred between cells of different tissues. This process has allowed several attempts to develop transplantation schemes by isolating functional mitochondria and introducing them into damaged tissue in particular to counteract the harmful effects of myocardial ischemia. Recently, mitochondrial transfer between brain cells has also been reported, and thus, mitochondrial transplantation for disorders of the nervous system has begun to be investigated. In this review, we focus on the relevance of mitochondria in the nervous system, as well as some mitochondrial alterations that occur in neurodegenerative diseases associated with age. In addition, we describe studies that have performed mitochondrial transplantation in various tissues, and we emphasize the advances in mitochondrial transplantation aimed at treating diseases of the nervous system.


Corresponding author: Clorinda Arias, Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70-228, 04510, Ciudad de México, México, E-mail:

Funding source: Fundación Miguel Alemán, A.C., UNAM, DGAPA, PAPIIT

Award Identifier / Grant number: IN20231

  1. Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This work was supported by Fundación Miguel Alemán, A.C., UNAM, DGAPA, PAPIIT grant number, IN20231.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2020-07-08
Accepted: 2020-09-29
Published Online: 2020-12-07
Published in Print: 2021-02-23

© 2020 Walter de Gruyter GmbH, Berlin/Boston

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