Abstract
Acute brain dysfunction associated with sepsis is a serious complication that results in morbidity and mortality. Intravenous immunoglobulin (IVIg) treatment is known to alleviate behavioral deficits in the experimentally induced model of sepsis. To delineate the mechanisms by which IVIg treatment prevents neuronal dysfunction, an array of immunological and apoptosis markers was investigated. Our results suggest that IVIgG and IgGAM administration ameliorates neuronal dysfunction and behavioral deficits by reducing apoptotic cell death and glial cell proliferation. IgGAM treatment might suppress classical complement pathway by reducing C5a activity and proapoptotic NF-κB and Bax expressions, thereby, inhibiting major inflammation and apoptosis cascades. Future animal model experiments performed with specific C5aR and NF-κB agonists/antagonists or C5aR-deficient mice might more robustly disclose the significance of these pathways. C5a, C5aR, and NF-κB, which were shown to be the key molecules in brain injury pathogenesis in sepsis, might also be utilized as potential targets for future treatment trials of septic encephalopathy.
References
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Articles in the same Issue
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Articles in the same Issue
- Frontmatter
- Neuroanatomy of conversion disorder: towards a network approach
- Calcitonin gene-related peptide (CGRP): role in peripheral nerve regeneration
- Role of central oxytocin and dopamine systems in nociception and their possible interactions: suggested hypotheses
- Mechanisms of disordered neurodegenerative function: concepts and facts about the different roles of the protein kinase RNA-like endoplasmic reticulum kinase (PERK)
- Mechanisms of action of intravenous immunoglobulin in septic encephalopathy
- Cracking novel shared targets between epilepsy and Alzheimer’s disease: need of the hour
- Therapeutic efficacy of specific immunotherapy for glioma: a systematic review and meta-analysis
- Crossover design in transcranial direct current stimulation studies on motor learning: potential pitfalls and difficulties in interpretation of findings