Abstract
Central oxytocin and dopamine have an important role in the process of nociception at the spinal level as well as supraspinal structures, e.g. anterior cingulate cortex, insular cortex, amygdala, nucleus accumbens, and hypothalamus. Many studies have pointed out the importance of both systems in the pain descending modulatory system and in pain-related symptoms in some chronic disorders, e.g. Parkinson disease and fibromyalgia. The interaction between oxytocin and dopamine systems has been addressed in some motivational behaviors, e.g. maternal and sexual behaviors, pair bonding, and salience. In this aspect, we propose that an oxytocin-dopamine interaction could be present in nociception, and we also explain the possible hypotheses of such an interaction between these systems.
Acknowledgments
M. Gamal-Eltrabily is a doctoral student from Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México (UNAM) and receives a fellowship (808245) from CONACyT. A. Manzano-García is a doctoral student from Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México (UNAM), and receives a fellowship (597467) from CONACyT. Thanks are due to Dr. Miguel Condés-Lara and Dr. Francisco Pellicer Graham for their aid in the preparation of the manuscript and their critical reviews, Funder name: Consejo Nacional de Ciencia y Tecnología, Funder Id: 10.13039/501100003141.
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Articles in the same Issue
- Frontmatter
- Neuroanatomy of conversion disorder: towards a network approach
- Calcitonin gene-related peptide (CGRP): role in peripheral nerve regeneration
- Role of central oxytocin and dopamine systems in nociception and their possible interactions: suggested hypotheses
- Mechanisms of disordered neurodegenerative function: concepts and facts about the different roles of the protein kinase RNA-like endoplasmic reticulum kinase (PERK)
- Mechanisms of action of intravenous immunoglobulin in septic encephalopathy
- Cracking novel shared targets between epilepsy and Alzheimer’s disease: need of the hour
- Therapeutic efficacy of specific immunotherapy for glioma: a systematic review and meta-analysis
- Crossover design in transcranial direct current stimulation studies on motor learning: potential pitfalls and difficulties in interpretation of findings
Articles in the same Issue
- Frontmatter
- Neuroanatomy of conversion disorder: towards a network approach
- Calcitonin gene-related peptide (CGRP): role in peripheral nerve regeneration
- Role of central oxytocin and dopamine systems in nociception and their possible interactions: suggested hypotheses
- Mechanisms of disordered neurodegenerative function: concepts and facts about the different roles of the protein kinase RNA-like endoplasmic reticulum kinase (PERK)
- Mechanisms of action of intravenous immunoglobulin in septic encephalopathy
- Cracking novel shared targets between epilepsy and Alzheimer’s disease: need of the hour
- Therapeutic efficacy of specific immunotherapy for glioma: a systematic review and meta-analysis
- Crossover design in transcranial direct current stimulation studies on motor learning: potential pitfalls and difficulties in interpretation of findings