PKMζ inhibition prevents the metaplastic change induced by conditioned taste aversion on insular cortex long-term potentiation in vivo
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Sandybel Ángeles-Durán
Abstract
The activity history of a given neuron or pathway has been suggested to influence its future responses to synaptic inputs. In particular, training in several learning tasks produces a metaplastic change, that is, a change in the ability to induce subsequent synaptic plasticity. Experimental evidence shows that the maintenance of long-term memory and long-term potentiation (LTP) requires the persistent action of the atypical protein kinase C isoform, protein kinase Mζ (PKMζ). Recent work has demonstrated that the inactivation of PKMζ in the insular cortex (IC) abolishes conditioned taste aversion (CTA) long-term memory. Our previous studies in the IC have demonstrated that the induction of LTP in the basolateral amygdaloid nucleus (Bla)-IC projection previous to CTA training enhances the retention of this task. Moreover, recently, we have observed that CTA training blocks the subsequent induction of LTP in the Bla-IC projection. The aim of the present study was to investigate the participation of PKMζ on the CTA-dependent modification of the ability to induce subsequent LTP in the Bla-IC projection in vivo. Thus, we have delivered high-frequency stimulation in the Bla-IC projection in order to induce in vivo IC-LTP in the rats that underwent or did not have an impairment of CTA retention due to the intracortical administration of the selective PKMζ pseudosubstrate inhibitory peptide, ZIP. Our results show that the microinfusion of ZIP into the IC of the behaving rats impairs long-term memory of CTA and prevents its effects on IC-LTP. These results indicate that PKMζ is a key component of the cellular mechanisms necessary for the persistence of lasting memory traces as well as for those underlying metaplastic changes in neocortex, contributing to the persistence of aversive memories.
©2012 by Walter de Gruyter Berlin Boston
Articles in the same Issue
- Masthead
- Masthead
- Guest Editorial
- Special Issue: The emotional brain and its relation to psychopathology
- Emotional modulation of the synapse
- Interplay of amygdala and insular cortex during and after associative taste aversion memory formation
- PKMζ inhibition prevents the metaplastic change induced by conditioned taste aversion on insular cortex long-term potentiation in vivo
- Taste and odor recognition memory: the emotional flavor of life
- Intense emotional experiences and enhanced training prevent memory loss induced by post-training amnesic treatments administered to the striatum, amygdala, hippocampus or substantia nigra
- Prefrontal/accumbal catecholamine system processes emotionally driven attribution of motivational salience
- Spatial memory, plasticity and nucleus accumbens
- Serotonin and emotion, learning and memory
- Contribution of serotonin type 3 receptors in the successful extinction of cued or contextual fear conditioned responses: interactions with GABAergic signaling
- Bombesin receptor regulation of emotional memory
- Estrogen, cognitive functions and emotion: an overview on humans, non-human primates and rodents in reproductive years
- Molecular brake pad hypothesis: pulling off the brakes for emotional memory
- Emotional modulation of multiple memory systems: implications for the neurobiology of post-traumatic stress disorder
- Modeling specific phobias and posttraumatic stress disorder in rodents: the challenge to convey both cognitive and emotional features
- Learning to cope with stress: psychobiological mechanisms of stress resilience
- Effects of parabolic flight and spaceflight on the endocannabinoid system in humans
- Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression
- Differences between the aging process and the chronic cerebrovascular impairment of memory functioning: the emotional and cognitive interaction
- A role for the superior colliculus in the modulation of threat responsiveness in primates: toward the ontogenesis of the social brain
- Cannabinoid modulation of mother-infant interaction: is it just about milk?
- Maternal exposure to low levels of corticosterone during lactation increases social play behavior in rat adolescent offspring
- Compulsive drug use and its neural substrates
- The role of the basal ganglia in motivated behavior
- The role of setting for ketamine abuse: clinical and preclinical evidence
Articles in the same Issue
- Masthead
- Masthead
- Guest Editorial
- Special Issue: The emotional brain and its relation to psychopathology
- Emotional modulation of the synapse
- Interplay of amygdala and insular cortex during and after associative taste aversion memory formation
- PKMζ inhibition prevents the metaplastic change induced by conditioned taste aversion on insular cortex long-term potentiation in vivo
- Taste and odor recognition memory: the emotional flavor of life
- Intense emotional experiences and enhanced training prevent memory loss induced by post-training amnesic treatments administered to the striatum, amygdala, hippocampus or substantia nigra
- Prefrontal/accumbal catecholamine system processes emotionally driven attribution of motivational salience
- Spatial memory, plasticity and nucleus accumbens
- Serotonin and emotion, learning and memory
- Contribution of serotonin type 3 receptors in the successful extinction of cued or contextual fear conditioned responses: interactions with GABAergic signaling
- Bombesin receptor regulation of emotional memory
- Estrogen, cognitive functions and emotion: an overview on humans, non-human primates and rodents in reproductive years
- Molecular brake pad hypothesis: pulling off the brakes for emotional memory
- Emotional modulation of multiple memory systems: implications for the neurobiology of post-traumatic stress disorder
- Modeling specific phobias and posttraumatic stress disorder in rodents: the challenge to convey both cognitive and emotional features
- Learning to cope with stress: psychobiological mechanisms of stress resilience
- Effects of parabolic flight and spaceflight on the endocannabinoid system in humans
- Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression
- Differences between the aging process and the chronic cerebrovascular impairment of memory functioning: the emotional and cognitive interaction
- A role for the superior colliculus in the modulation of threat responsiveness in primates: toward the ontogenesis of the social brain
- Cannabinoid modulation of mother-infant interaction: is it just about milk?
- Maternal exposure to low levels of corticosterone during lactation increases social play behavior in rat adolescent offspring
- Compulsive drug use and its neural substrates
- The role of the basal ganglia in motivated behavior
- The role of setting for ketamine abuse: clinical and preclinical evidence
