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Medicinal inorganic chemistry: an updated review on the status of metallodrugs and prominent metallodrug candidates

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Published/Copyright: March 9, 2021

Abstract

Metallodrugs correspond to a small portion of all available drugs in the market and, yet, some of them are among the most used and important drugs in modern medicine. However, medicinal inorganic chemistry remains an underestimated area within medicinal chemistry and the main reason is the mislead association of metals to toxic agents. Thus, in this review, the potential of medicinal inorganic chemistry in drug designing is highlighted through a description of the current status of metallodrugs and metallodrug candidates in advanced clinical trials. The broad spectrum of application of metal-based drugs in medicine for both therapy and diagnosis is addressed by the extensive list of examples presented herein.


Corresponding author: Victor M. Miranda, Instituto de Química de São Carlos, Universidade de São Paulo, São Carlos, SP, Brazil, E-mail:

Funding source: Coordenação de Aperfeiçoamento de Pessoal do Nível Superior (CAPES)

Funding source: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Acknowledgements

The author is thankful to the Brazilian agencies for research funding: Coordenação de Aperfeiçoamento de Pessoal do Nível Superior (CAPES) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: The study was supported by the Brazilian agencies: Coordenação de Aperfeiçoamento de Pessoal do Nível Superior (CAPES) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2020-12-08
Accepted: 2021-02-24
Published Online: 2021-03-09
Published in Print: 2022-03-28

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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