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The association between maternal perfluoroalkylated substances exposure and neonatal birth weight: a system review and meta-analysis

  • Zeyuan Fu , Xiaoyi Sun , Xupu Yang , Xiaoqian Li , Yizhe Zhang , Xiaolin Zhang , Huicai Guo , Yi Liu and Xuehui Liu EMAIL logo
Published/Copyright: February 10, 2025
Reviews on Environmental Health
From the journal Reviews on Environmental Health Volume 40 Issue 2

Abstract

Some studies have shown that maternal exposure to perfluoroalkyl substances (PFAS) may be related to the neonatal birth weight. The purpose of this study was to explore this relationship between maternal exposure to PFAS and neonatal birth weight. All papers published before March 2024 were retrieved from the Web of Science, PubMed, and Embase databases. A thorough meta-analysis was carried out, involving data extracted from 1,673 samples obtained from a total of 24 articles. Our study found a significantly negative association between maternal PFOS exposure and neonatal birth weight (β= −71.55; 95 %CI= −114.47, −28.62), with high heterogeneity (I 2 =64.15 %, p<0.0001). Similarly, there was a significant negative correlation between maternal PFOA exposure and neonatal birth weight (β= −81.26; 95 %CI= −126.08, −36.43), with high heterogeneity (I 2 =67.23 %, p<0.0001). Subunit analysis showed that there was a significantly negative correlation between PFOS exposure and neonatal birth weight in mid-to-late pregnancy and after delivery (β= −97.87; 95 %CI= −181.83, −13.92, β= −138.06; 95 %CI= −255.91, −20.20), PFOA exposure showed a negative correlation with neonatal birth weight in mid-to-late pregnancy (β= −85.89; 95 %CI= −139.31, −32.47), while PFNA exposure also showed a negative correlation with neonatal birth weight in mid-to-late pregnancy (β= −90.39; 95 %CI= −152.90, −27.88). However, no significant correlation was observed for PFNA exposure (β=3.95; 95% CI= −10.41, 18.31), with medium heterogeneity (I 2 =40.56 %, p=0.0574), or for PFHxS exposure (β=4.61; 95 %CI= −10.60, 19.81), with medium heterogeneity (I 2 =29.27 %, p=0.1368). Further research is needed to better understand the implications of these findings on maternal and neonatal health.

Keywords: perfluoroalkylated substances; neonatal birth weight; maternal exposure; systematic review; meta-analysis
Corresponding author: Xuehui Liu, Department of Occupational and Environmental Health, Hebei Key Laboratory of Environment and Human Health, School of Public Health, Hebei Medical University, Zhongshan East Road 361, Shijiazhuang, 050017, Hebei, PR China, E-mail:
Zeyuan Fu and Xiaoyi Sun contributed equally to this work and share first authorship

Acknowledgements

The authors sincerely acknowledge the editors for their suggestions and the anonymous reviewers selected by the editors for their comments. The authors acknowledge the research fund of the National Natural Science Foundation of China (Project No. 21976050).

  1. Research ethics: Not applicable.

  2. Informed consent: Not applicable.

  3. Author Contributions: Conceived and designed the experiments: Xuehui Liu, Xiaolin Zhang, Huicai Guo, Yi Liu; Performed the experiments: Zeyuan Fu, Xupu Yang, Xiaoqian Li, Yizhe Zhang; Analyzed the data: Zeyuan Fu; Contributed analysis tools: Zeyuan Fu; Wrote the paper: Xuehui Liu, Zeyuan Fu, Xiaoyi Sun. All authors read and approved the final manuscript.

  4. Use of Large Language Models, AI and Machine Learning Tools: None declared.

  5. Conflict of Interest: The authors state no conflict of interest.

  6. Research funding: This work was supported by the National Natural Science Foundation of China (grant number 21976050).

  7. Data availability: Not applicable.

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/reveh-2023-0174).

Received: 2023-12-13
Accepted: 2025-01-06
Published Online: 2025-02-10
Published in Print: 2025-06-26

© 2025 Walter de Gruyter GmbH, Berlin/Boston

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  21. A critical appraisal of the WHO 2024 systematic review of the effects of RF-EMF exposure on tinnitus, migraine/headache, and non-specific symptoms
https://doi.org/10.1515/reveh-2023-0174
Keywords for this article
perfluoroalkylated substances; neonatal birth weight; maternal exposure; systematic review; meta-analysis

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Analytical methods, source, concentration, and human risks of microplastics: a review
  4. Solid fuel use and low birth weight: a systematic review and meta-analysis
  5. The human health effects of unconventional oil and gas (UOG) chemical exposures: a scoping review of the toxicological literature
  6. WHO to build neglect of RF-EMF exposure hazards on flawed EHC reviews? Case study demonstrates how “no hazards” conclusion is drawn from data showing hazards
  7. The role of environmental pollution in the development of pulmonary exacerbations in cystic fibrosis: a narrative review
  8. Semi-IPN polysaccharide-based hydrogels for effective removal of heavy metal ions and dyes from wastewater: a comprehensive investigation of performance and adsorption mechanism
  9. A structured review of the associations between breast cancer and exposures to selected organic solvents
  10. A review of the potential adverse health impacts of atrazine in humans
  11. Comprehensive approach to clinical decision-making strategy, illustrated by the Gulf War
  12. A systematic review and quality assessment of estimated daily intake of microplastics through food
  13. Adapting to heat-health vulnerability in temperate climates: current adaptation and mitigation responses and future predictions in Aotearoa New Zealand
  14. Evaluation of the impact of environmental pollutants on the sex ratio: a systematic review
  15. A critical review on the toxicological and epidemiological evidence integration for assessing human health risks to environmental chemical exposures
  16. The association between screen exposure and autism spectrum disorder in children: meta-analysis
  17. The association between maternal perfluoroalkylated substances exposure and neonatal birth weight: a system review and meta-analysis
  18. School built environment and children’s health: a scientometric analysis
  19. Letter to the Editors
  20. Underground power lines as a confounding factor in observational studies concerning magnetic fields and childhood leukemia
  21. A critical appraisal of the WHO 2024 systematic review of the effects of RF-EMF exposure on tinnitus, migraine/headache, and non-specific symptoms
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