Startseite Medizin Nano-engineered vitamins as a potential epigenetic modifier against environmental air pollutants
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Nano-engineered vitamins as a potential epigenetic modifier against environmental air pollutants

  • Pooja Ratre , Prachi Chauhan , Arpit Bhargava , Rajnarayan Tiwari , Suresh Thareja , Rupesh Kumar Srivastava und Pradyumna Kumar Mishra ORCID logo EMAIL logo
Veröffentlicht/Copyright: 21. Juni 2022
Reviews on Environmental Health
Aus der Zeitschrift Reviews on Environmental Health Band 38 Heft 3

Abstract

Air pollution has emerged as a serious threat to human health due to close association with spectrum of chronic ailments including cardiovascular disorders, respiratory diseases, nervous system dysfunctions, diabetes and cancer. Exposure to air-borne pollutants along with poor eating behaviours and inferior dietary quality irreversibly impacts epigenomic landscape, leading to aberrant transcriptional control of gene expression which is central to patho-physiology of non-communicable diseases. It is assumed that nutriepigenomic interventions such as vitamins can control such adverse effects through their immediate action on mitochondrial epigenomic-axis. Importantly, the exhaustive clinical utility of vitamins-interceded epigenetic synchronization is not well characterized. Therefore, improving the current limitations linked to stability and bioavailability issues in vitamin formulations is highly warranted. The present review not only sums up the available data on the role of vitamins as potential epigenetic modifiers but also discusses the importance of nano-engineered vitamins as potential epidrugs for dietary and pharmacological intervention to mitigate the long-term effects of air pollution toxicity.

Keywords: air pollution; environmental health; epigenetic modifications; nano-medicine; particulate matter; translational research
Corresponding author: Prof. (Dr.) Pradyumna Kumar Mishra, MS, PhD, Fulbright-Nehru Fellow (USA), AIMF, FAMS, Scientist-F & Head, Department of Molecular Biology, ICMR-National Institute for Research in Environmental Health, Bypass Road, Bhauri, Bhopal (MP) - 462001, India, Mobile: +91 94799 83943, E-mail: .
Pooja Ratre, Prachi Chauhan and Arpit Bhargava contributed equally

Funding source: ICMR, Intra-mural funding support (PKM)

Award Identifier / Grant number: Unassigned

Acknowledgements

The authors are thankful to the Indian Council of Medical Research (ICMR), Department of Health Research (DHR), Ministry of Health and Family Welfare (MoHFW), Government of India, New Delhi (India) for necessary funding support to the laboratory of Professor Pradyumna Kumar Mishra.

  1. Research funding: This work was supported by ICMR, Intra-mural funding support (PKM).

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not Applicable.

  5. Ethical approval: Not Applicable.

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Received: 2022-02-09
Accepted: 2022-05-23
Published Online: 2022-06-21
Published in Print: 2023-09-26

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. Determination of safe levels of persistent organic pollutants in toxicology and epidemiology
  4. A critical analysis of the MOBI-Kids study of wireless phone use in childhood and adolescence and brain tumor risk
  5. Occupational and environmental noise exposure during pregnancy and rare health outcomes of offspring: a scoping review focusing on congenital anomalies and perinatal mortality
  6. Exposure to air pollution and risk of ovarian cancer: a review
  7. Evaluation of the impact of different disinfectants on new coronavirus and human health
  8. A review on chromium health hazards and molecular mechanism of chromium bioremediation
  9. A review of the characteristic properties of selected tobacco chemicals and their associated etiological risks
  10. Using biomonitoring as a complementary approach in BTEX exposure assessment in the general population and occupational settings: a systematic review and meta-analysis
  11. Review, meta-analysis and carcinogenic risk assessment of aflatoxin M1 in different types of milks in Iran
  12. The effect of long-term exposure to toxic air pollutants on the increased risk of malignant brain tumors
  13. Self-referencing authorships behind the ICNIRP 2020 radiation protection guidelines
  14. Nano-engineered vitamins as a potential epigenetic modifier against environmental air pollutants
  15. The effect of toxic air pollutants on fertility men and women, fetus and birth rate
  16. A systematic review of photocatalytic degradation of humic acid in aqueous solution using nanoparticles
  17. Letter to the Editor
  18. Dariusz Leszczynski responds to comments of Maël Dieudonné on Leszczynski’s review of the scientific evidence on the individual sensitivity to electromagnetic fields (EHS)
https://doi.org/10.1515/reveh-2022-0027
Schlagwörter für diesen Artikel
air pollution; environmental health; epigenetic modifications; nano-medicine; particulate matter; translational research

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. Determination of safe levels of persistent organic pollutants in toxicology and epidemiology
  4. A critical analysis of the MOBI-Kids study of wireless phone use in childhood and adolescence and brain tumor risk
  5. Occupational and environmental noise exposure during pregnancy and rare health outcomes of offspring: a scoping review focusing on congenital anomalies and perinatal mortality
  6. Exposure to air pollution and risk of ovarian cancer: a review
  7. Evaluation of the impact of different disinfectants on new coronavirus and human health
  8. A review on chromium health hazards and molecular mechanism of chromium bioremediation
  9. A review of the characteristic properties of selected tobacco chemicals and their associated etiological risks
  10. Using biomonitoring as a complementary approach in BTEX exposure assessment in the general population and occupational settings: a systematic review and meta-analysis
  11. Review, meta-analysis and carcinogenic risk assessment of aflatoxin M1 in different types of milks in Iran
  12. The effect of long-term exposure to toxic air pollutants on the increased risk of malignant brain tumors
  13. Self-referencing authorships behind the ICNIRP 2020 radiation protection guidelines
  14. Nano-engineered vitamins as a potential epigenetic modifier against environmental air pollutants
  15. The effect of toxic air pollutants on fertility men and women, fetus and birth rate
  16. A systematic review of photocatalytic degradation of humic acid in aqueous solution using nanoparticles
  17. Letter to the Editor
  18. Dariusz Leszczynski responds to comments of Maël Dieudonné on Leszczynski’s review of the scientific evidence on the individual sensitivity to electromagnetic fields (EHS)
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