Abstract
A scoping review was performed to answer: what environmental health concerns have been associated with adverse health outcomes in the Navajo Nation? The review focused on occupational and ambient environmental exposures associated with human industrial activities. The search strategy was implemented in PubMed, and two investigators screened the retrieved literature. Thirteen studies were included for review. Data were extracted using the matrix method. Six studies described associations between work in uranium mining and cancer. Six studies focused on environmental exposures to uranium mine waste and other metals, with outcomes that included biological markers, kidney disease, diabetes and hypertension, and adverse birth outcomes. One study explored occupational exposure to Sin Nombre Virus and infection. Most research has focused on the health effects of uranium, where occupational exposures occurred among miners and environmental exposures are a legacy of uranium mining and milling. Gaps exist with respect to health outcomes associated with current occupations and the psychosocial impact of environmental hazards. Other environmental exposures and hazards are known to exist on the Navajo Nation, which may warrant epidemiologic research.
Funding source: National Institute for Occupational Safety and Health
Award Identifier / Grant number: T42/OH008414
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Research funding: SC was supported by the Rocky Mountain Center for Occupational and Environmental Health. CDC/NIOSH T42/OH008414.
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Author contributions: SC and RMJ conceived of the study, performed the literature search, review and extraction. SC, RMJ and DS wrote and edited the manuscript. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors sate no conflict of interest.
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Informed consent: Not applicable.
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Ethical approval: The conducted research is not related to either human or animal use.
References
1. Pardilla, M, Prasad, D, Suratkar, S, Gittelsohn, J. High levels of household food insecurity on the Navajo Nation. Publ Health Nutr 2014;17:58–65. https://doi.org/10.1017/s1368980012005630.Search in Google Scholar PubMed
2. Linn, A. A forgotten health crisis in Navajo lands; 2018. https://centerforhealthjournalism.org/2018/07/08/forgotten-health-crisis-navajo-lands [Accessed 29 Jul 2021].Search in Google Scholar
3. Hutchinson, RN, Shin, S. Systematic review of health disparities for cardiovascular diseases and associated factors among American Indian and Alaska Native populations. PLoS One 2014;9:e80973. https://doi.org/10.1371/journal.pone.0080973.Search in Google Scholar PubMed PubMed Central
4. Brugge, D, Goble, R. The history of uranium mining and the Navajo people. Am J Publ Health 2002;92:1410–9. https://doi.org/10.2105/ajph.92.9.1410.Search in Google Scholar PubMed PubMed Central
5. Arksey, H, O’Malley, L. Scoping studies: towards a methodological framework. Int J Soc Res Methodol 2005;8:19–32. https://doi.org/10.1080/1364557032000119616.Search in Google Scholar
6. Tricco, AC, Lillie, E, Zarin, W, O’Brien, KK, Colquhoun, H, Levac, D, et al.. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med 2018;169:467–73. https://doi.org/10.7326/m18-0850.Search in Google Scholar
7. Gottleib, LS, Husen, LA. Lung cancer among Navajo uranium miners. Chest 1982;81:449–52.10.1378/chest.81.4.449Search in Google Scholar PubMed
8. Gilliland, FD, Hunt, WC, Pardilla, M, Key, CR. Uranium mining and lung cancer among Navajo men in New Mexico and Arizona, 1969–1993. J Occup Environ Med 2000;42:278–83. https://doi.org/10.1097/00043764-200003000-00008.Search in Google Scholar PubMed
9. Butler, C, Samet, JM, Black, WC, Key, CR, Kutvirt, DM. Histopathologic findings of lung cancer in Navajo men: relationship to U mining. Health Phys 1986;51:365–8.Search in Google Scholar
10. Mulloy, KB, James, DS, Mohs, K, Kornfeld, M. Lung cancer in a nonsmoking underground uranium miner. Environ Health Perspect 2001;109:305–9. https://doi.org/10.1289/ehp.01109305.Search in Google Scholar PubMed PubMed Central
11. Roscoe, RJ, Deddens, JA, Slavan, A, Schnorr, TM. Mortality among Navajo uranium miners. Am J Publ Health 1995;85:535–40. https://doi.org/10.2105/ajph.85.4.535.Search in Google Scholar PubMed PubMed Central
12. Samet, JM, Kutvirt, DM, Waxeiler, RJ, Key, CR. Uranium mining and lung cancer in Navajo men. N Engl J Med 1984;310:1481–4. https://doi.org/10.1056/nejm198406073102301.Search in Google Scholar
13. Dashner-Titus, EJ, Hoover, J, Luo, L, Lee, JH, Du, R, Liu, JL, et al.. Metal exposure and oxidative stress markers in pregnant Navajo Birth Cohort Study participants. Free Radic Biol Med 2018;124:484–92. https://doi.org/10.1016/j.freeradbiomed.2018.04.579.Search in Google Scholar PubMed PubMed Central
14. Shields, LM, Wiese, WH, Skipper, BJ, Charley, B, Benally, L. Navajo birth outcomes in the Shiprock uranium mining area. Health Phys 1992;63:542–51. https://doi.org/10.1097/00004032-199211000-00005.Search in Google Scholar PubMed
15. Erdei, E, Shuey, C, Miller, C, Pacheco, B, Cajero, M, Lewis, J, et al.. Elevated autoimmunity in residents living near abandoned uranium mine sites on the Navajo Nation. J Autoimmun 2019;99:15–23. https://doi.org/10.1016/j.jaut.2019.01.006.Search in Google Scholar PubMed PubMed Central
16. Harmon, ME, Lewis, J, Miller, C, Hoover, J, Ali, AMS, Shuey, C, et al.. Arsenic association with circulating oxidized low-density lipoprotein in a Native American community. J Toxicol Environ Health A 2018;81:535–48. https://doi.org/10.1080/15287394.2018.1443860.Search in Google Scholar PubMed PubMed Central
17. Zeitz, PS, Graber, JM, Voorhees, RA, Kioski, C, Shands, LA, Ksiazek, TG, et al.. Assessment of occupational risk for hantavirus infection in Arizona and New Mexico. J Occup Environ Med 1997;39:463–7. https://doi.org/10.1097/00043764-199705000-00013.Search in Google Scholar PubMed
18. Hund, L, Bedrick, EJ, Miller, C, Huerta, G, Nez, T, Ramone, S, et al.. A Bayesian framework for estimating disease risk due to exposure to uranium mine and mill waste on the Navajo Nation. J Roy Stat Soc A 2015;178:1069–91. https://doi.org/10.1111/rssa.12099.Search in Google Scholar
19. Harmon, ME, Lewis, J, Miller, C, Hoover, J, Ali, AMS, Shuey, C, et al.. Residential proximity to abandoned uranium mines and serum inflammatory potential in chronically exposed Navajo communities. J Expo Sci Environ Epidemiol 2017;27:365–71. https://doi.org/10.1038/jes.2016.79.Search in Google Scholar PubMed PubMed Central
20. Wagoner, JK, Archer, VE, Lundin, FE, Holaday, DA, Lloyd, JW. Radiation as the cause of lung cancer among uranium miners. N Engl J Med 1965;273:181–8. https://doi.org/10.1056/nejm196507222730402.Search in Google Scholar
21. Moure-Eraso, R. Observational studies as human experimentation: the uranium mining experience in the Navajo Nation (1947–66). New Solut 1999;9:163–78. https://doi.org/10.2190/4cb2-7n1d-jjr6-hgex.Search in Google Scholar
22. Lewis, J, Hoover, J, MacKenzie, D. Mining and environmental health disparities in Native American communities. Curr Environ Health Rep 2017;4:130–41. https://doi.org/10.1007/s40572-017-0140-5.Search in Google Scholar PubMed PubMed Central
23. Hoover, JH, Erdei, E, Begay, D, Gonzales, M, NBCS Study Team, Jarrett, JM, et al.. Exposure to uranium and co-occurring metals among pregnant Navajo women. Environ Res 2020;190:109943. https://doi.org/10.1016/j.envres.2020.109943.Search in Google Scholar PubMed PubMed Central
24. Rock, T, Camplain, R, Teufel-Shone, NI, Ingram, JC. Traditional sheep consumption by Navajo people in Cameron, Arizona. Int J Environ Res Publ Health 2019;16:4195. https://doi.org/10.3390/ijerph16214195.Search in Google Scholar PubMed PubMed Central
25. Lin, Y, Hoover, J, Beene, D, Erdei, E, Liu, Z. Environmental risk mapping of potential abandoned uranium mine contamination on the Navajo Nation, USA, using a GIS-based multi-criteria decision analysis approach. Environ Sci Pollut Res 2020;27:30542–57. https://doi.org/10.1007/s11356-020-09257-3.Search in Google Scholar PubMed PubMed Central
26. Environmental Protection Agency [EPA]. Ten-year plan: federal actions to address impacts of uranium contamination on the Navajo Nation, 2020–2029; 2020. https://www.epa.gov/navajo-nation-uranium-cleanup/abandoned-mines-cleanup-federal-plans [Accessed 20 Jul 2021].Search in Google Scholar
27. Brenner, C, Reisinger, KS, Rogers, KD. Navajo infant mortality, 1970. Publ Health Rep 1974;89:353–9.Search in Google Scholar
28. Finn, S, Herne, M, Castille, D. The value of traditional ecological knowledge for the environmental health sciences and biomedical research. Environ Health Perspect 2017;125:085006. https://doi.org/10.1289/EHP858.Search in Google Scholar PubMed PubMed Central
29. Lewis, J, Gonzales, M, Burnette, C, Benally, M, Seanez, P, Shuey, C, et al.. Environmental exposures to metals in Native communities and implications for child development: basis for the Navajo Birth Cohort Study. J Soc Work Disabil Rehabil 2015;14:245–69. https://doi.org/10.1080/1536710x.2015.1068261.Search in Google Scholar PubMed
30. Dawson, SE, Madsen, GE. American Indian uranium millworkers: a study of the perceived effects of occupational exposure. J Health Soc Pol 1995;7:19–31. https://doi.org/10.1300/j045v07n02_02.Search in Google Scholar PubMed
31. Markstrom, CA, Charley, PH. Psychological effects of technological/human-caused environmental disasters: examination of the Navajo and uranium. Am Indian Alaska Native Ment Health Res 2003;11:19–45. https://doi.org/10.5820/aian.1101.2003.19.Search in Google Scholar PubMed
32. Van Horne, YO, Chief, K, Charley, PH, Begay, MG, Lothrop, N, Bell, ML, et al.. Impacts to Diné activites with the San Juan River after the Gold King Mine spill. J Expo Sci Environ Epidemiol 2021;31:852–66. https://doi.org/10.1038/s41370-021-00290-z. Feb 1. PMID: 33526814; PMCID: PMC8325715.Search in Google Scholar PubMed PubMed Central
33. Yazzie, SA, Davis, S, Sexias, N. Yost MG assessing the impact of housing features and environmental factors on home indoor radon concentration levels on the Navajo Nation. Int J Environ Res Publ Health 2020;17:2813. https://doi.org/10.3390/ijerph17082813.Search in Google Scholar PubMed PubMed Central
34. Robin, LF, Less, PS, Winget, M, Steinhoff, M, Moulton, LH, Santosham, M, et al.. Wood burning stove and lower respiratory illnesses in Navajo children. Pediatr Infect Dis J 1996;15:859–65. https://doi.org/10.1097/00006454-199610000-00006.Search in Google Scholar PubMed
35. Lowe, AA, Bender, B, Liu, AH, Solomon, T, Kobernick, A, Morgan, W, et al.. Environmental concerns for children with asthma on the Navajo Nation. Ann Am Thorac Soc 2018;15:745–53. https://doi.org/10.1513/annalsats.201708-674ps.Search in Google Scholar
36. Powell, J, Isom, S, Divers, J, Bellatorre, A, Johnson, M, Smiley, J, et al.. Increasing burden of type 2 diabetes in Navajo youth: the SEARCH for Diabetes in Youth Study. Pediatr Diabetes 2019;20:815–20. https://doi.org/10.1111/pedi.12885.Search in Google Scholar PubMed PubMed Central
37. Schumacher, C, Ferucci, ED, Lanier, AP, Slattery, ML, Schraer, CD, Raymer, TW, et al.. Metabolic syndrome: prevalence among American Indian and Alaska Native people living in the Southwestern United States and in Alaska. Metab Syndr Relat Disord 2008;6:267–73. https://doi.org/10.1089/met.2008.0021.Search in Google Scholar PubMed PubMed Central
© 2021 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Mini Reviews
- Unani medicinal herbs as potential air disinfectants: an evidence-based review
- Safety assessment of natural products in Malaysia: current practices, challenges, and new strategies
- Environmental and occupational health on the Navajo Nation: a scoping review
- Review Articles
- Understanding Holism in the light of principle underlying practice of Unani Medicine
- Investigating the field effectiveness of respirators against metal particle exposure in various workplaces: a systematic review
- To which extent are per-and poly-fluorinated substances associated to metabolic syndrome?
- Reactive nitrogen compounds and their influence on human health: an overview
- Millimeter (MM) wave and microwave frequency radiation produce deeply penetrating effects: the biology and the physics
- Air pollution increases the risk of pulmonary embolism: a meta-analysis
- Housing and health in vulnerable social groups: an overview and bibliometric analysis
- Environmental arsenic exposure and its toxicological effect on thyroid function: a systematic review
- Letters to the Editor
- Comments on Martin Pall, “Millimeter (MM) wave and microwave frequency radiation produce deeply penetrating effects: the biology and the physics”, Rev Environ Health 2021;37:247–58.
- Comments on Pall’s “Millimeter (MM) wave and microwave frequency radiation produce deeply penetrating effects: the biology and the physics”
- ‘Proof of EHS beyond all reasonable doubt’. Comment on: Leszczynski D. Review of the scientific evidence on the individual sensitivity to electromagnetic fields (EHS). Rev Environ Health 2021; https://doi.org/10.1515/reveh-2021-0038. Online ahead of print
- Why scientifically unfounded and misleading claim should be dismissed to make true research progress in the acknowledgment of electrohypersensibility as a new worldwide emerging pathology
- Comments on the article by Dariusz Leszczynski: Review of the scientific evidence on the individual sensitivity to electromagnetic fields (EHS). Rev Environ Health 2021
Articles in the same Issue
- Frontmatter
- Mini Reviews
- Unani medicinal herbs as potential air disinfectants: an evidence-based review
- Safety assessment of natural products in Malaysia: current practices, challenges, and new strategies
- Environmental and occupational health on the Navajo Nation: a scoping review
- Review Articles
- Understanding Holism in the light of principle underlying practice of Unani Medicine
- Investigating the field effectiveness of respirators against metal particle exposure in various workplaces: a systematic review
- To which extent are per-and poly-fluorinated substances associated to metabolic syndrome?
- Reactive nitrogen compounds and their influence on human health: an overview
- Millimeter (MM) wave and microwave frequency radiation produce deeply penetrating effects: the biology and the physics
- Air pollution increases the risk of pulmonary embolism: a meta-analysis
- Housing and health in vulnerable social groups: an overview and bibliometric analysis
- Environmental arsenic exposure and its toxicological effect on thyroid function: a systematic review
- Letters to the Editor
- Comments on Martin Pall, “Millimeter (MM) wave and microwave frequency radiation produce deeply penetrating effects: the biology and the physics”, Rev Environ Health 2021;37:247–58.
- Comments on Pall’s “Millimeter (MM) wave and microwave frequency radiation produce deeply penetrating effects: the biology and the physics”
- ‘Proof of EHS beyond all reasonable doubt’. Comment on: Leszczynski D. Review of the scientific evidence on the individual sensitivity to electromagnetic fields (EHS). Rev Environ Health 2021; https://doi.org/10.1515/reveh-2021-0038. Online ahead of print
- Why scientifically unfounded and misleading claim should be dismissed to make true research progress in the acknowledgment of electrohypersensibility as a new worldwide emerging pathology
- Comments on the article by Dariusz Leszczynski: Review of the scientific evidence on the individual sensitivity to electromagnetic fields (EHS). Rev Environ Health 2021