Startseite Medizin Application of metabolomics to characterize environmental pollutant toxicity and disease risks
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Application of metabolomics to characterize environmental pollutant toxicity and disease risks

  • Pan Deng , Xusheng Li , Michael C. Petriello , Chunyan Wang , Andrew J. Morris und Bernhard Hennig EMAIL logo
Veröffentlicht/Copyright: 13. August 2019
Reviews on Environmental Health
Aus der Zeitschrift Reviews on Environmental Health Band 34 Heft 3

Abstract

The increased incidence of non-communicable human diseases may be attributed, at least partially, to exposures to toxic chemicals such as persistent organic pollutants (POPs), air pollutants and heavy metals. Given the high mortality and morbidity of pollutant exposure associated diseases, a better understanding of the related mechanisms of toxicity and impacts on the endogenous host metabolism are needed. The metabolome represents the collection of the intermediates and end products of cellular processes, and is the most proximal reporter of the body’s response to environmental exposures and pathological processes. Metabolomics is a powerful tool for studying how organisms interact with their environment and how these interactions shape diseases related to pollutant exposure. This mini review discusses potential biological mechanisms that link pollutant exposure to metabolic disturbances and chronic human diseases, with a focus on recent studies that demonstrate the application of metabolomics as a tool to elucidate biochemical modes of actions of various environmental pollutants. In addition, classes of metabolites that have been shown to be modulated by multiple environmental pollutants will be discussed with an emphasis on their use as potential early biomarkers of disease risks. Taken together, metabolomics is a useful and versatile tool for characterizing the disease risks and mechanisms associated with various environmental pollutants.

Keywords: disease; heavy metal; metabolomics; pollutant; POP; toxicity
Corresponding author: Bernhard Hennig, PhD, Superfund Research Center, University of Kentucky, Rm. 501 Wethington Health Sciences Bldg, 900 S. Limestone Street, Lexington, KY 40536-0200, USA; and Department of Animal and Food Sciences, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, USA, Phone: +1-859-218-1387 or 1-859-218-1343, Fax: +1-859-257-1811

Acknowledgements

We thank Tom Dolan (Medical Illustration, College of Medicine, University of Kentucky) for preparing Figure 1.

  1. Research funding: This work was supported in part by NIEHS/NIH P42ES007380 and Funder Id: http://dx.doi.org/10.13039/100000066, K99ES028734.

  2. Conflict of interest: The authors declare they have no actual or potential competing conflict of financial interest relevant to this work.

  3. Informed consent: Not applicable.

  4. Ethical approval: Not applicable.

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Received: 2019-04-22
Accepted: 2019-07-23
Published Online: 2019-08-13
Published in Print: 2019-09-25

©2019 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/reveh-2019-0030
Schlagwörter für diesen Artikel
disease; heavy metal; metabolomics; pollutant; POP; toxicity

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. International scientists seek solutions for environmental problems
  4. Reviews
  5. A link between environmental pollution and civilization disorders: a mini review
  6. Applying community resilience theory to engagement with residents facing cumulative environmental exposure risks: lessons from Louisiana’s industrial corridor
  7. Mini Reviews
  8. Building science approaches for vapor intrusion studies
  9. Application of metabolomics to characterize environmental pollutant toxicity and disease risks
  10. Advancing science in rapidly changing environments: opportunities for the Central and Eastern European Conference on Health and the Environment to connect to other networks
  11. Original Articles
  12. Monitoring and assessment of formaldehyde levels in residential areas from two cities in Romania
  13. Agreement between parental and student reports on respiratory symptoms and school environment in young Romanian children – evidence from the SINPHONIE project
  14. Impact of plant growth regulators and soil properties on Miscanthus x giganteus biomass parameters and uptake of metals in military soils
  15. Community resilience and critical transformations: the case of St. Gabriel, Louisiana
  16. Short Communication
  17. The ecological risk assessment of soil contamination with Ti and Fe at military sites in Ukraine: avoidance and reproduction tests with Folsomia candida
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Heruntergeladen am 6.12.2025 von https://www.degruyterbrill.com/document/doi/10.1515/reveh-2019-0030/html
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