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Development of gelatin nanoparticles for positron emission tomography diagnosis in pancreatic cancer

  • Yumi Sugo , Atsushi Kimura ORCID logo , Tomoya Koizumi , Kotaro Oyama ORCID logo and Mitsumasa Taguchi ORCID logo EMAIL logo
Published/Copyright: September 3, 2024
Radiochimica Acta
From the journal Radiochimica Acta Volume 112 Issue 12

Abstract

Pancreatic cancer remains difficult to diagnose using currently available imaging probes. Thus, this study aimed to develop a novel imaging agent for the diagnosis of pancreatic cancer using positron emission tomography (PET). Specifically, this study explores gelatin-based nanoparticles fabricated via radiation-induced crosslinking, as gelatin is known for its ability to produce biocompatible materials. Aqueous gelatin solutions were irradiated with γ-rays to produce nanoparticles with average diameters of 5–20 nm via a radiation crosslinking technique. The gelatin nanoparticles were labeled with 64Cu, exhibiting negative surface potentials. Furthermore, the nanoparticles were evaluated in vivo by injecting them into pancreatic tumor-bearing mice. Notably, the nanoparticles accumulated in the tumors. Hence, 64Cu-labeled gelatin nanoparticles show promise as a platform for next-generation PET imaging agents for pancreatic cancer.

Keywords: gelatin; nanoparticle; radiation crosslinking; 64Cu; pancreatic cancer diagnosis
Corresponding author: Mitsumasa Taguchi, Takasaki Institute for Advanced Quantum Science, National Institutes for Quantum Science and Technology (QST), 1233 Watanuki-machi, Takasaki, Gunma, 370-1292 Japan; and Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjintyo, Kiryu, Gunma, Japan, E-mail:

Acknowledgments

The authors thank Dr. Noriaki Seko (QST) for analyzing the radiation-crosslinked gelatin nanoparticles; Dr. Noriko S. Ishioka (QST) for her valuable discussion and helpful advice; and all members of Medical Radioisotope Applications Project and the operating crew of TIARA for their continuous support. The authors would like to thank Editage (www.editage.com) for the English language editing.

  1. Research ethics: All procedures involving animals were conducted in accordance with the ethical standards of National Institutes for Quantum Science and Technology and were approved by the Animal Ethics Committee.

  2. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  3. Competing interests: The authors declare no conflicts of interest regarding this article.

  4. Research funding: This research was partially supported by Kakenhi (Grant Nos. 20K20915 and 23K11713) and the Innovative Science and Technology Initiative for Security (Grant Number JPJ004596, ATLA, Japan).

  5. Data availability: The data are available from the corresponding author upon reasonable request.

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Received: 2024-05-06
Accepted: 2024-08-01
Published Online: 2024-09-03
Published in Print: 2024-12-17

© 2024 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Original Papers
  3. The collaboratively selective uranyl adsorption of marine fungal modification biosorbent linked by the open-chain polyether terminal with amidoxime
  4. Assessment of certain theoretical modeling for extraction data of uranium ion by loaded SM-7 with TBP using fixed bed column operation
  5. Study on separation of ReO4−, a substitute for TcO4−, using functional ionic liquid impregnated extraction chromatography resins
  6. Synergistic extraction of some divalent cations into nitrobenzene by using dicarbollylcobaltate and substituted calix[5]arenes
  7. Development of gelatin nanoparticles for positron emission tomography diagnosis in pancreatic cancer
  8. Radiochemical separation of 161 Tb from neutron irradiated Gd target by liquid-liquid extraction technique
  9. Influence of gamma irradiation on germination traits, growth and biochemical attributes of dragon fruit (Selenicereus monacanthus)
  10. Thermoluminescence response of Ce doped CaTiO3 nanophosphor synthesized by hydrothermal method for gamma dosimetry
  11. Significant influence of La2O3 content on radiation shielding characteristics properties of bismuth sodium borosilicate glasses
  12. The effect of rare earths (Nd3+, Er3+, Yb3+) additives on the radiation shielding properties of the tungsten oxide modified tellurite glasses
https://doi.org/10.1515/ract-2024-0304
Keywords for this article
gelatin; nanoparticle; radiation crosslinking; 64Cu; pancreatic cancer diagnosis

Articles in the same Issue

  1. Frontmatter
  2. Original Papers
  3. The collaboratively selective uranyl adsorption of marine fungal modification biosorbent linked by the open-chain polyether terminal with amidoxime
  4. Assessment of certain theoretical modeling for extraction data of uranium ion by loaded SM-7 with TBP using fixed bed column operation
  5. Study on separation of ReO4−, a substitute for TcO4−, using functional ionic liquid impregnated extraction chromatography resins
  6. Synergistic extraction of some divalent cations into nitrobenzene by using dicarbollylcobaltate and substituted calix[5]arenes
  7. Development of gelatin nanoparticles for positron emission tomography diagnosis in pancreatic cancer
  8. Radiochemical separation of 161 Tb from neutron irradiated Gd target by liquid-liquid extraction technique
  9. Influence of gamma irradiation on germination traits, growth and biochemical attributes of dragon fruit (Selenicereus monacanthus)
  10. Thermoluminescence response of Ce doped CaTiO3 nanophosphor synthesized by hydrothermal method for gamma dosimetry
  11. Significant influence of La2O3 content on radiation shielding characteristics properties of bismuth sodium borosilicate glasses
  12. The effect of rare earths (Nd3+, Er3+, Yb3+) additives on the radiation shielding properties of the tungsten oxide modified tellurite glasses
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