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Determination of radioprotective and genotoxic properties of sulfamide derivatives

  • Bünyamin Aygün , Burak Alaylar EMAIL logo , Akın Akıncıoğlu , Bünyamin Alım , Ebu Talip Kocaman , Mehmet Karadayı , Mohammed Ibrahim Abu Al-Sayyed , Şeyma Aksu , Erdem Şakar , Özgür Fırat Özpolat , Süleyman Göksu , Medine Güllüce und Abdulhalik Karabulut
Veröffentlicht/Copyright: 27. Oktober 2021
Radiochimica Acta
Aus der Zeitschrift Radiochimica Acta Band 109 Heft 12

Abstract

Some potential drug active substances with the ability to reduce the effects of radiation on human tissues and cells were investigated. For this purpose, eight different types of sulfamide derivatives were synthesized and nuclear radiation protection parameters were determined. Neutron radiation reduction parameters such as the half-value layer effective removal cross-sections, mean free path, and the number of particles passing through the sample were determined with GEANT4 code. Additionally, the gamma radiation attenuation parameters of the materials examined were determined using Phy-X/PSD software in the energy area of 0.015–15 MeV. These parameters are the half-value layer, mass attenuation coefficient, mean free path, exposure buildup factor and effective atomic number. Neutron radiation absorption experiments were applied using an 241Am-Be fast neutron source. All results obtained for neutron radiation were compared with paraffin and water. It has been found that the ability of sulfamide derivatives to absorb these radiations is superior to reference materials. To determine whether these derivatives could have adverse effects on human health, their genotoxic potential was determined using the Ames/Salmonella bacterial reversion test. The results showed that these derivatives can be considered genotoxically safe in tests at concentrations up to 5 mM. Thus, it is suggested that the derivative materials examined in this study can be used as active substances for a drug to be made for protection against both neutron and gamma radiation.

Keywords: Ames test; gamma; neutron; sulfamide; sulfamoyl carbamate
Corresponding author: Burak Alaylar, Department of Molecular Biology and Genetics, Faculty of Science and Arts, Agri Ibrahim Cecen University, Agri, Turkey, E-mail:

Funding source: Scientific and Technological Research Council of Turkey

Award Identifier / Grant number: Grant No. 112T881

Funding source: Ataturk University

  1. Author contributions: Burak Alaylar, Bünyamin Aygün, Akın Akıncıoğlu and Mehmet Karadayı designed and conducted the experiments. Süleyman Göksu, Akın Akıncıoğlu and Ebu Talip Kocaman synthesized sulfamide derivatives. Mehmet Karadayı, Burak ALAYLAR and Şeyma Aksu tested to geno-toxic potential of sulfamide derivatives. Bünyamin Aygün, Bünyamin Alım, Mohammed Ibrahim Abu Al-Sayyed, Erdem Şakar, Özgür Fırat Özpolat analysed neutron and gamma experiment data. Abdulhalik Karabulut, Medine Güllüce and Süleyman Göksu analyzed data. Burak Alaylar, Bünyamin Aygün, Akın Akıncıoğlu and Bünyamin Alım wrote the manuscript. All authors read and approved the manuscript.

  2. Research funding: The authors are indebted to the Scientific and Technological Research Council of Turkey (TÜBITAK, Grant No. 112T881) and Ataturk University for their financial support of this work.

  3. Conflict of interest statement: No potential conflict of interest was reported by the author(s).

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Received: 2021-08-02
Accepted: 2021-09-28
Published Online: 2021-10-27
Published in Print: 2021-12-20

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Original Papers
  3. Effect of adding dodecanol as modifier to N,N,N′,N′-tetra-n-hexyl-3,6-dithiaoctane-1,8-diamide silica-based adsorbent on the adsorption behaviors of platinum-group metals and other metals from simulated high-level liquid waste
  4. A new way to ensure selective zirconium ion adsorption
  5. Determination of radioprotective and genotoxic properties of sulfamide derivatives
  6. Synthesis of 111In-p-SCN-Bn-DTPA-nimotuzumab and its preclinical evaluation in EGFR positive NSCLC animal model
  7. Instrumental neutron activation analysis (INAA) of zinc concentrations in scalp hair and fingernails samples of Algerian females with breast cancer
  8. Soil mineral analysis and environmental radioactivity in Ghizer, Eastern Hindukush, Pakistan
  9. Natural and anthropogenic radioactivity in some vegetables and fruits commonly consumed in the Western Black Sea region of Turkey
https://doi.org/10.1515/ract-2021-1088
Schlagwörter für diesen Artikel
Ames test; gamma; neutron; sulfamide; sulfamoyl carbamate

Artikel in diesem Heft

  1. Frontmatter
  2. Original Papers
  3. Effect of adding dodecanol as modifier to N,N,N′,N′-tetra-n-hexyl-3,6-dithiaoctane-1,8-diamide silica-based adsorbent on the adsorption behaviors of platinum-group metals and other metals from simulated high-level liquid waste
  4. A new way to ensure selective zirconium ion adsorption
  5. Determination of radioprotective and genotoxic properties of sulfamide derivatives
  6. Synthesis of 111In-p-SCN-Bn-DTPA-nimotuzumab and its preclinical evaluation in EGFR positive NSCLC animal model
  7. Instrumental neutron activation analysis (INAA) of zinc concentrations in scalp hair and fingernails samples of Algerian females with breast cancer
  8. Soil mineral analysis and environmental radioactivity in Ghizer, Eastern Hindukush, Pakistan
  9. Natural and anthropogenic radioactivity in some vegetables and fruits commonly consumed in the Western Black Sea region of Turkey
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