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Preparation, biological evaluation and radiolabeling of [99mTc]-technetium tricarbonyl procainamide as a tracer for heart imaging in mice

  • M. H. Sanad EMAIL logo , Fawzy A. Marzook , Ayman B. Farag EMAIL logo , Sudip Kumar Mandal , Syed F. A. Rizvi and Jeetendra Kumar Gupta
Published/Copyright: January 31, 2022
Radiochimica Acta
From the journal Radiochimica Acta Volume 110 Issue 4

Abstract

This study focuses on the synthesis and preliminary bio-evaluation of [99mTc]-technetium tricarbonyl procainamide ([99mTc]-technetium tricarbony PA) as a viable cardiac imaging agent. The compound, [99mTc]-technetium tricarbony PA, was synthesized by labelling procainamide with a [99mTc]-technetium tricarbonyl core, yielding a high radiochemical yield and radiochemical purity of 98%. Under optimal circumstances, high radiochemical yield and purity were obtained utilizing [99mTc]-technetium tricarbonyl core within 30 min of incubation at pH 9, 200 µg substrate concentration, and 100 °C reaction temperature. The heart showed a high absorption of 32.39 ± 0.88% of the injected dose/g organ (ID/g), confirming the suitability of [99mTc]-technetium tricarbonyl PA as a viable complex for heart imaging.

Keywords: biodistribution; heart imaging; [99mTc]-tricarbonyl core; [99mTc]-tricarbonyl procainamide
Corresponding author: M. H. Sanad, Labeled Compounds Department, Hot Laboratories Center, Egyptian Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt; and Department of Physics and Engineering Mathematics, Faculty of Engineering, Ain Shams University, P.O. Box 11566, Cairo, Egypt; and Ayman B. Farag, Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt, E-mail: (M.H.S), (A.B.F)

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2021-07-16
Accepted: 2022-01-10
Published Online: 2022-01-31
Published in Print: 2022-04-26

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Original Papers
  3. Unique transport behaviour of Am(III)/Eu(III) ions across a supported liquid membrane containing a TREN-based diglycolamide dendrimer ligand
  4. A novel CPE procedure by oil-in-water microemulsion for preconcentrating and analyzing thorium and uranium
  5. Separation of 103Pd from a Rh target using an alloying pretreatment with bismuth
  6. Experimental and computational study of rafoxanide radioiodination via isotopic exchange reaction
  7. Preparation, biological evaluation and radiolabeling of [99mTc]-technetium tricarbonyl procainamide as a tracer for heart imaging in mice
  8. Gamma radiation shielding performance and physico-chemical properties of poly (vinyl alcohol)/Cd(NO3)2 composite films
https://doi.org/10.1515/ract-2021-1079
Keywords for this article
biodistribution; heart imaging; [99mTc]-tricarbonyl core; [99mTc]-tricarbonyl procainamide

Articles in the same Issue

  1. Frontmatter
  2. Original Papers
  3. Unique transport behaviour of Am(III)/Eu(III) ions across a supported liquid membrane containing a TREN-based diglycolamide dendrimer ligand
  4. A novel CPE procedure by oil-in-water microemulsion for preconcentrating and analyzing thorium and uranium
  5. Separation of 103Pd from a Rh target using an alloying pretreatment with bismuth
  6. Experimental and computational study of rafoxanide radioiodination via isotopic exchange reaction
  7. Preparation, biological evaluation and radiolabeling of [99mTc]-technetium tricarbonyl procainamide as a tracer for heart imaging in mice
  8. Gamma radiation shielding performance and physico-chemical properties of poly (vinyl alcohol)/Cd(NO3)2 composite films
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