Experimental and computational study of rafoxanide radioiodination via isotopic exchange reaction
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Heba Hussien
und
Ahmed M. Rashad
Abstract
The current study is an attempt to confirm the possibility of using rafoxanide (Raf) for diagnostic or radiotherapeutic purpose based on the radioiodine used in the labeling process. The isotopic exchange reaction was performed to radiolabel Raf. The maximum radiochemical yield of [125I]Raf (90%) was obtained when 20 μL of Na[125I]I (7.4 MBq (200 μCi)) in the reaction flask was added to 100 μg of Raf (0.799 mM) within 20 min at 140 °C. High pressure liquid chromatography was used to purify the labeled product of [125I]Raf. The activation energy was calculated experimentally in both ethyl acetate and methanol as reaction medium and found to be 22.82 kJ/mol and 24.43 kJ/mol, respectively. Furthermore, Gaussian 09 used the density function theory (DFT) to calculate the activation energy of the reaction in the two solvents.
Acknowledgment
The authors want to give many thanks to the Chemistry Department, Faculty of Science and Arts at Al-rass, Qassim University, KSA. for help and support.
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Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: None declared.
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Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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© 2022 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Original Papers
- Unique transport behaviour of Am(III)/Eu(III) ions across a supported liquid membrane containing a TREN-based diglycolamide dendrimer ligand
- A novel CPE procedure by oil-in-water microemulsion for preconcentrating and analyzing thorium and uranium
- Separation of 103Pd from a Rh target using an alloying pretreatment with bismuth
- Experimental and computational study of rafoxanide radioiodination via isotopic exchange reaction
- Preparation, biological evaluation and radiolabeling of [99mTc]-technetium tricarbonyl procainamide as a tracer for heart imaging in mice
- Gamma radiation shielding performance and physico-chemical properties of poly (vinyl alcohol)/Cd(NO3)2 composite films
Artikel in diesem Heft
- Frontmatter
- Original Papers
- Unique transport behaviour of Am(III)/Eu(III) ions across a supported liquid membrane containing a TREN-based diglycolamide dendrimer ligand
- A novel CPE procedure by oil-in-water microemulsion for preconcentrating and analyzing thorium and uranium
- Separation of 103Pd from a Rh target using an alloying pretreatment with bismuth
- Experimental and computational study of rafoxanide radioiodination via isotopic exchange reaction
- Preparation, biological evaluation and radiolabeling of [99mTc]-technetium tricarbonyl procainamide as a tracer for heart imaging in mice
- Gamma radiation shielding performance and physico-chemical properties of poly (vinyl alcohol)/Cd(NO3)2 composite films
