Radioiodination of olmesartan medoxomil and biological evaluation of the product as a tracer for cardiac imaging
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M. H. Sanad
,
Ebtisam. A. Marzook
Abstract
The present study is oriented to synthesis of radioiodinated olmesartan medoxomil (OM) for potential cardiac imaging. Olmesartan medoxomil has been labeled with [125/131I] using chloramine-T (Ch-T) as an oxidizing agent. The key effective factors such as amount of oxidizing agent, amount of substrate, pH, reaction temperature and reaction time, have been systematically studied to get high radiochemical yield of the [125I]olmesartan medoxomil reaching values of 98.5%. The labeled compound was separated and purified using thin layer chromatography (TLC), paper electrophoresis and high performance liquid chromatography (HPLC). The biological distribution indicates the suitability of [125I]olmesartan medoxomil as a novel tracer to image heart with high heart/blood ratio within 30 min which was detected by gamma camera.
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©2018 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Redox behavior and solubility of plutonium under alkaline, reducing conditions
- Effects of temperature on the extraction of U(VI) and Pu(IV) by tris(2-methylbutyl) phosphate from nitric acid media
- Interaction of salicylic acid with zirconium diphosphate and its reactivity toward uranium (VI)
- Complexation of a macrocyclic ligand, 2,6-di (N-methyl)formamide-calix[4]pyridine, with Eu(III) and extraction of Eu(III) and Am(III)
- Feasibility studies of using N,N-dihexyloctanamide (DHOA) for fast reactor fuel reprocessing applications
- Encapsulated polymeric beads impregnating unexplored amide, N,N′-bis(2-ethyl hexyl) α-hydroxy acetamide (BEHGA) – preparation, sorption and kinetic studies for tri-, tetra- and hexavalent radionuclides
- Radioiodination of olmesartan medoxomil and biological evaluation of the product as a tracer for cardiac imaging
- Investigation of chemical composition and moisture content for different materials on the attenuation of γ rays
Artikel in diesem Heft
- Frontmatter
- Redox behavior and solubility of plutonium under alkaline, reducing conditions
- Effects of temperature on the extraction of U(VI) and Pu(IV) by tris(2-methylbutyl) phosphate from nitric acid media
- Interaction of salicylic acid with zirconium diphosphate and its reactivity toward uranium (VI)
- Complexation of a macrocyclic ligand, 2,6-di (N-methyl)formamide-calix[4]pyridine, with Eu(III) and extraction of Eu(III) and Am(III)
- Feasibility studies of using N,N-dihexyloctanamide (DHOA) for fast reactor fuel reprocessing applications
- Encapsulated polymeric beads impregnating unexplored amide, N,N′-bis(2-ethyl hexyl) α-hydroxy acetamide (BEHGA) – preparation, sorption and kinetic studies for tri-, tetra- and hexavalent radionuclides
- Radioiodination of olmesartan medoxomil and biological evaluation of the product as a tracer for cardiac imaging
- Investigation of chemical composition and moisture content for different materials on the attenuation of γ rays
