Oxidative radioiodination of meclofenoxate as a preclinical brain imaging agent
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Mohamed Abd El-Motaleb Abd El-Rhman
,
Ismail Taha Ibrahim
Abstract
Meclofenoxate is a drug used to cause a broad improvement in brain function and mental performance. Meclofenoxate was successfully labeled with 125I via direct electrophilic substitution reaction at room temperature. Percent radiochemical yield was evaluated by paper electrophoresis and HPLC. The reaction parameters affecting the preparation process were studied in details. 125I-meclofenoxate gave maximum percent radiochemical yield of about 95 ± 1.0% with specific activity 1.9 μCi/μg meclofenoxate and its stability was up to 4 h. Biodistribution studies showed that maximum uptake of 125I-meclofenoxate in the brain of mice was 4.27 ± 0.3% injected dose (ID)/g tissue organ at 15 min post-injection. This uptake of 125I-meclofenoxate was found to be enough to image brain as it still 4.3% ID/g at 30 min post injection.
©2016 Walter de Gruyter Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- A review on the mass spectrometric analysis of thorium
- Characterization of reversed micelles formed in solvent extraction of thorium(IV) by bis(2-ethylhexyl) phosphoric acid. Transforming from rodlike to wormlike morphology
- Pre-concentration of trace levels of rare-earth elements in high purity uranium samples for nuclear forensic purposes
- Characterization of Fe(III)-saturated montmorillonite and evaluation its sorption behavior for U(VI)
- Oxidative radioiodination of meclofenoxate as a preclinical brain imaging agent
- Molecular imaging investigations of a 67Ga/64Cu labeled bivalent ligand, [RGD-Glu-(DO3A)-6-Ahx-RM2], targeting GRPR/αvβ3 biomarkers: a comparative study
- Recent sedimentation rates in the Caravelas estuary (Bahia, Brazil) using unsupported 210Pb and 137Cs modeling
Artikel in diesem Heft
- Frontmatter
- A review on the mass spectrometric analysis of thorium
- Characterization of reversed micelles formed in solvent extraction of thorium(IV) by bis(2-ethylhexyl) phosphoric acid. Transforming from rodlike to wormlike morphology
- Pre-concentration of trace levels of rare-earth elements in high purity uranium samples for nuclear forensic purposes
- Characterization of Fe(III)-saturated montmorillonite and evaluation its sorption behavior for U(VI)
- Oxidative radioiodination of meclofenoxate as a preclinical brain imaging agent
- Molecular imaging investigations of a 67Ga/64Cu labeled bivalent ligand, [RGD-Glu-(DO3A)-6-Ahx-RM2], targeting GRPR/αvβ3 biomarkers: a comparative study
- Recent sedimentation rates in the Caravelas estuary (Bahia, Brazil) using unsupported 210Pb and 137Cs modeling
