Pharmaceutical cocrystal consisting of ascorbic acid with p-aminobenzoic acid and paracetamol
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Fatima Miles
,
Nourelhouda Bensiradj
Abstract
As small molecule drugs become harder to develop and less cost effective for patient use, efficient strategies for their property improvement become increasingly important for global health initiatives. As a new crystal engineering strategy, cocrystals have opened a new way to modify the physicochemical properties of pharmaceutical solids. Improvements in the physical properties of Active Pharmaceutical Ingredients (APIs) without changes in the covalent chemistry have been possible through the application of binary component solids. In this work, a pharmaceutical cocrystal of ascorbic acid (A) + para-aminobenzoic acid (B) and ascorbic acid (A) + paracetamol (P) cocrystal are synthesized and characterized by PXRD, DSC, and FT-IR. FT-IR indicates the kind of interactions occurring between API and coformer. The DSC thermogram for (A–B) cocrystal showed a single endothermic peak attributed to the melting temperature at 155 °C. The thermal behavior of the cocrystal was distinct with different melting temperatures from that seen with either of the individual components; this suggests the formation of a new phase. As molecular modeling is presented as a support to the experiment, a computational study using density functional theory (DFT) at the level of the WB97XD functional and 6-311 + G (d, p) basis set was carried out using the Gaussian 09 program. This theoretical study made it possible to calculate the energetic properties, the intramolecular hydrogen bonds as well as the thermodynamic properties for the two cocrystals.
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: None declared.
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Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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Articles in the same Issue
- Frontmatter
- Reviews
- Synthesis and application of organotellurium compounds
- Tellurium-based chemical sensors
- Synthesis of antiviral drugs by using carbon–carbon and carbon–heteroatom bond formation under greener conditions
- Green protocols for Tsuji–Trost allylation: an overview
- Chemistry of tellurium containing macrocycles
- Tellurium-induced cyclization of olefinic compounds
- Latest developments on the synthesis of bioactive organotellurium scaffolds
- Tellurium-based solar cells
- Semiconductor characteristics of tellurium and its implementations
- Tellurium based materials for nonlinear optical applications
- Pharmaceutical cocrystal consisting of ascorbic acid with p-aminobenzoic acid and paracetamol
- Carbocatalysis: a metal free green avenue towards carbon–carbon/heteroatom bond construction
- Physico-chemical and nutraceutical properties of Cola lepidota seed oil
- Cyclohexane oxidation using advanced oxidation processes with metals and metal oxides as catalysts: a review
- Optimization of electrolysis and carbon capture processes for sustainable production of chemicals through Power-to-X
- Tellurium-induced functional group activation
- Synthesis, characterization, and theoretical investigation of 4-chloro-6(phenylamino)-1,3,5-triazin-2-yl)asmino-4-(2,4-dichlorophenyl)thiazol-5-yl-diazenyl)phenyl as potential SARS-CoV-2 agent
- Process intensification and digital twin – the potential for the energy transition in process industries
- Photovoltaic properties of novel reactive azobenzoquinolines: experimental and theoretical investigations
- Accessing the environmental impact of tellurium metal
- Membrane-based processes in essential oils production
- Development of future-proof supply concepts for sector-coupled district heating systems based on scenario-analysis
- Educators’ reflections on the teaching and learning of the periodic table of elements at the upper secondary level: a case study
- Optimization of hydrogen supply from renewable electricity including cavern storage
- A short review on cancer therapeutics
- The role of bioprocess systems engineering in extracting chemicals and energy from microalgae
- The topology of crystalline matter
- Characterization of lignocellulosic S. persica fibre and its composites: a review
- Constructing a framework for selecting natural fibres as reinforcements composites based on grey relational analysis
- Polybutylene succinate (PBS)/natural fiber green composites: melt blending processes and tensile properties
- The properties of 3D printed poly (lactic acid) (PLA)/poly (butylene-adipate-terephthalate) (PBAT) blend and oil palm empty fruit bunch (EFB) reinforced PLA/PBAT composites used in fused deposition modelling (FDM) 3D printing
- Thermal properties of wood flour reinforced polyamide 6 biocomposites by twin screw extrusion
- Manufacturing defects and interfacial adhesion of Arenga Pinnata and kenaf fibre reinforced fibreglass/kevlar hybrid composite in boat construction application
- Wettability of keruing (Dipterocarpus spp.) wood after weathering under tropical climate
- Simultaneous remediation of polycyclic aromatic hydrocarbon and heavy metals in wastewater with zerovalent iron-titanium oxide nanoparticles (ZVI-TiO2)
Articles in the same Issue
- Frontmatter
- Reviews
- Synthesis and application of organotellurium compounds
- Tellurium-based chemical sensors
- Synthesis of antiviral drugs by using carbon–carbon and carbon–heteroatom bond formation under greener conditions
- Green protocols for Tsuji–Trost allylation: an overview
- Chemistry of tellurium containing macrocycles
- Tellurium-induced cyclization of olefinic compounds
- Latest developments on the synthesis of bioactive organotellurium scaffolds
- Tellurium-based solar cells
- Semiconductor characteristics of tellurium and its implementations
- Tellurium based materials for nonlinear optical applications
- Pharmaceutical cocrystal consisting of ascorbic acid with p-aminobenzoic acid and paracetamol
- Carbocatalysis: a metal free green avenue towards carbon–carbon/heteroatom bond construction
- Physico-chemical and nutraceutical properties of Cola lepidota seed oil
- Cyclohexane oxidation using advanced oxidation processes with metals and metal oxides as catalysts: a review
- Optimization of electrolysis and carbon capture processes for sustainable production of chemicals through Power-to-X
- Tellurium-induced functional group activation
- Synthesis, characterization, and theoretical investigation of 4-chloro-6(phenylamino)-1,3,5-triazin-2-yl)asmino-4-(2,4-dichlorophenyl)thiazol-5-yl-diazenyl)phenyl as potential SARS-CoV-2 agent
- Process intensification and digital twin – the potential for the energy transition in process industries
- Photovoltaic properties of novel reactive azobenzoquinolines: experimental and theoretical investigations
- Accessing the environmental impact of tellurium metal
- Membrane-based processes in essential oils production
- Development of future-proof supply concepts for sector-coupled district heating systems based on scenario-analysis
- Educators’ reflections on the teaching and learning of the periodic table of elements at the upper secondary level: a case study
- Optimization of hydrogen supply from renewable electricity including cavern storage
- A short review on cancer therapeutics
- The role of bioprocess systems engineering in extracting chemicals and energy from microalgae
- The topology of crystalline matter
- Characterization of lignocellulosic S. persica fibre and its composites: a review
- Constructing a framework for selecting natural fibres as reinforcements composites based on grey relational analysis
- Polybutylene succinate (PBS)/natural fiber green composites: melt blending processes and tensile properties
- The properties of 3D printed poly (lactic acid) (PLA)/poly (butylene-adipate-terephthalate) (PBAT) blend and oil palm empty fruit bunch (EFB) reinforced PLA/PBAT composites used in fused deposition modelling (FDM) 3D printing
- Thermal properties of wood flour reinforced polyamide 6 biocomposites by twin screw extrusion
- Manufacturing defects and interfacial adhesion of Arenga Pinnata and kenaf fibre reinforced fibreglass/kevlar hybrid composite in boat construction application
- Wettability of keruing (Dipterocarpus spp.) wood after weathering under tropical climate
- Simultaneous remediation of polycyclic aromatic hydrocarbon and heavy metals in wastewater with zerovalent iron-titanium oxide nanoparticles (ZVI-TiO2)
