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Polycaprolactone/epoxide-functionalized silica composite microparticles for long-term controlled release of trans-chalcone

  • Yasemin Kaptan ORCID logo EMAIL logo and Yüksel Güvenilir
Published/Copyright: December 5, 2022
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Journal of Polymer Engineering
From the journal Journal of Polymer Engineering Volume 43 Issue 2

Abstract

In this study, controlled release of trans-chalcone was achieved by using a polycaprolactone-based hybrid system as the drug carrier material. Encapsulation efficiency was obtained in the range of 70–75% for various formulations and in vitro release studies, conducted at 37 °C and pH 7.4, revealed slow profile reaching 60% cumulative release. As interpreted from kinetic modelling, drug release was controlled mainly by Fickian diffusion; polymer erosion did not contribute to the TC release. Difference in drug loading efficiencies of the hybrid and neat PCL microparticles was observed such that PCL microparticles had lower loading efficiency than the hybrid microparticles whereas the release profiles were similar. pH of the release medium had affected release profiles; acidic medium enhanced drug release. Characterization of the microparticles were realized by FT-IR, TGA, DSC, SEM and WCA which revealed key properties such as molecular dispersion state and hydrophilicity. With the results obtained, we concluded that our hybrid system has a significant potential for long term release of trans-chalcone.

Keywords: 3-GPTMS; controlled release; microparticles; polycaprolactone; silica; trans-chalcone
Corresponding author: Yasemin Kaptan, Department of Chemical Engineering, Istanbul Technical University, İstanbul 34469, Turkey, E-mail:

Funding source: Istanbul Teknik Ãœniversitesi

Award Identifier / Grant number: MDK-2019-42177

Acknowledgements

The FT-IR analysis was provided by Beykent University Chemical Engineering Department.

  1. Author contributions: All the authors have accepted respon-sibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This study is funded by Istanbul Technical University Scientific Research Projects Coordination Depart-ment. Grant number: MDK-2019-42177.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/polyeng-2021-0343).

Received: 2022-01-20
Accepted: 2022-09-27
Published Online: 2022-12-05
Published in Print: 2023-02-23

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/polyeng-2021-0343
Keywords for this article
3-GPTMS; controlled release; microparticles; polycaprolactone; silica; trans-chalcone

Articles in the same Issue

  1. Frontmatter
  2. Material Properties
  3. The effect of filler loading and APTES treatment on the performance of PSf/SBA-15 mixed matrix membranes
  4. Artificial intelligence based prediction models for rubber compounds
  5. Synthesis and memory properties of a series of novel asymmetric soluble polyimides
  6. Preparation and Assembly
  7. Fabrication of high strength and functional GO/PVA/PAN ternary composite fibers by gel spinning
  8. Polycaprolactone/epoxide-functionalized silica composite microparticles for long-term controlled release of trans-chalcone
  9. Rapid incorporation of gold nanoparticles onto graphene oxide-polymer nanofiber membranes for photothermally-accelerated water purification
  10. Sustained oxygen release of hydrogen peroxide-acrylic resin inclusion complex for aquaculture
  11. Engineering and Processing
  12. Reducing component stress during encapsulation of electronics: a simulative examination of thermoplastic foam injection molding
  13. Influence of production process-induced surface topologies at varying roughness depths on the tribological properties of polyamide steel contact
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