Ibuprofen loaded nano-ethanolic liposomes carbopol gel system: in vitro characterization and anti-inflammatory efficacy assessment in Wistar rats
-
Atefeh Afshar Moghaddam
,
Farhan J. Ahmad
Abstract
The objective of the present study was to develop and characterize nano-ethanolic liposomes (NEL) for transdermal delivery of ibuprofen (IBU). The NEL for transdermal delivery of IBU were prepared by thin film hydration technique and evaluated for vesicle size, shape, entrapment efficiency, transdermal flux, and in vivo anti-inflammatory activity in Wistar rats. The NEL optimized formulation (NEL-Opt) presented vesicle sizes of 32.85±1.98 nm and entrapment efficiency of 86.40±0.55% with improved transdermal flux. The presence of ethanol and flexibility of NEL could be the reasons for better permeation enhancement of IBU via rat’s skin. In vivo anti-inflammatory study of IBU-loaded NEL-Opt gel showed significant reduction (41.18%) of edema in carrageenan-induced rat paw edema as compared to conventional gel of IBU, where reduction of edema was found to be 12.50%. Our results suggest that developed NEL formulations are efficient systems for transdermal IBU delivery against inflammation. The stability study confirmed that the NEL-Opt gel formulation was considerably stable at refrigerator temperature. Our results concluded that NEL are an efficient carrier for transdermal delivery of IBU.
Acknowledgments
Atefeh Afshar Moghaddam is grateful to JAGSONPAL Pharmaceuticals Ltd. (Faridabad, India) for providing a gift sample of IBU. Gratitude is also extended to Lipoid Company (GmbH, Germany) for proving a gift sample of Phospholipon® 90 G for pursuing this research work.
Conflict of interest statement: All authors have approved the final manuscript, and the authors declare that they have no conflicts of interest to disclose.
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©2018 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Material properties
- Influence of particle size of isotactic polypropylene (iPP) on barrier property against agglomeration of homogenized microcrystalline cellulose (HMCC) in iPP/HMCC composites
- An investigation of the impact of an amino-ended hyperbranched polymer as a new type of modifier on the compatibility of PLA/PBAT blends
- Study on the adhesive properties of reactive liquid rubber toughened epoxy-clay hybrid nanocomposites
- Morphology, rheology and biodegradation of oxo-degradable polypropylene/polylactide blends
- Long term hydrothermal effect on the mechanical and thermo-mechanical properties of carbon nanofiber doped epoxy composites
- Long term accelerated aging investigation of an epoxy/silica nanocomposite for high voltage insulation
- Mechanical and morphological properties of modified halloysite nanotube filled ethylene-vinyl acetate copolymer nanocomposites
- Evaluation of polypropylene hybrid composites containing glass fiber and basalt powder
- Preparation and assembly
- Ibuprofen loaded nano-ethanolic liposomes carbopol gel system: in vitro characterization and anti-inflammatory efficacy assessment in Wistar rats
- Preparation of oriented bacterial cellulose nanofibers by flowing medium-assisted biosynthesis and influence of flowing velocity
- Engineering and processing
- Thin-wall injection molding of high-density polyethylene for infrared radiation system lenses
- Replication of micro-structured injection molds using physical vapor deposition coating and dynamic laser mold tempering
Articles in the same Issue
- Frontmatter
- Material properties
- Influence of particle size of isotactic polypropylene (iPP) on barrier property against agglomeration of homogenized microcrystalline cellulose (HMCC) in iPP/HMCC composites
- An investigation of the impact of an amino-ended hyperbranched polymer as a new type of modifier on the compatibility of PLA/PBAT blends
- Study on the adhesive properties of reactive liquid rubber toughened epoxy-clay hybrid nanocomposites
- Morphology, rheology and biodegradation of oxo-degradable polypropylene/polylactide blends
- Long term hydrothermal effect on the mechanical and thermo-mechanical properties of carbon nanofiber doped epoxy composites
- Long term accelerated aging investigation of an epoxy/silica nanocomposite for high voltage insulation
- Mechanical and morphological properties of modified halloysite nanotube filled ethylene-vinyl acetate copolymer nanocomposites
- Evaluation of polypropylene hybrid composites containing glass fiber and basalt powder
- Preparation and assembly
- Ibuprofen loaded nano-ethanolic liposomes carbopol gel system: in vitro characterization and anti-inflammatory efficacy assessment in Wistar rats
- Preparation of oriented bacterial cellulose nanofibers by flowing medium-assisted biosynthesis and influence of flowing velocity
- Engineering and processing
- Thin-wall injection molding of high-density polyethylene for infrared radiation system lenses
- Replication of micro-structured injection molds using physical vapor deposition coating and dynamic laser mold tempering
