Preparation of poly(sebacic anhydride) and polylactic acid pills used as drug carrier for levofloxacin controlled release
-
Zhuan Zhang
,
Jie Gao
Abstract
A biodegradable local drug release system consisting of poly(sebacic anhydride) and polylactic acid was developed for the purpose of osteomyelitis therapy. Five kinds of poly(sebacic anhydride) with different molecular weights were synthesized, and levofloxacin was chosen as a model antibacterial drug in the in vitro release within 38 days. As the molecular weight of poly(sebacic anhydride) increased, the melting point (Tm) of the matrices increased and the surface morphology became smoother. Consequently, the initial burst effect was reduced and the release rate significantly decreased. In addition, the kinetics of pills containing poly(sebacic anhydride) (Mw=13,000) were close to zero order release. The release profile reveals that the thermodynamic properties and morphology of these matrices, which are affected by the molecular weight, are essential for developing controllable delivery systems. The drug release rate could be easily controlled by the molecular weight of the poly(sebacic anhydride). Finally, these prospective results allow the biodegradable controlled release systems to be employed as carriers for the treatment of chronic osteomyelitis, as well as for other medical applications.
This work was supported by the Natural Science Foundation of Hubei Province (2000J052) and the Dominant Discipline’s Leader Project of Wuhan (20065006131-02).
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©2013 by Walter de Gruyter Berlin Boston
Articles in the same Issue
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- Degradation of epoxidized natural rubber compatibilized linear low density polyethylene/ soya powder blends: the effect of natural weathering
- Effect of compatibilizing agents on the physical properties of iPP/HDPE organoclay blends
- Thermal and mechanical properties of ultrahigh molecular weight polyethylene/high-density polyethylene/polyethylene glycol blends
- Effect of MMT concentrations as reinforcement on the properties of recycled PET/HDPE nanocomposites
- Three-dimensional viscoelastic simulation of the effect of wall slip on encapsulation in the coextrusion process
- Studies on thin films of PVC-PMMA blend polymer electrolytes
- Morphological study of PVDF/PMMA/TiO2 blend films prepared by melt casting process
- Effects of calcium stearate and metal hydroxide additions on the irradiated LDPE/EVA compound properties
- Preparation of poly(sebacic anhydride) and polylactic acid pills used as drug carrier for levofloxacin controlled release
- Gray optimization of process parameters of surface modification of coconut sheath reinforced polymer composites
Articles in the same Issue
- Masthead
- Masthead
- Original articles
- Degradation of epoxidized natural rubber compatibilized linear low density polyethylene/ soya powder blends: the effect of natural weathering
- Effect of compatibilizing agents on the physical properties of iPP/HDPE organoclay blends
- Thermal and mechanical properties of ultrahigh molecular weight polyethylene/high-density polyethylene/polyethylene glycol blends
- Effect of MMT concentrations as reinforcement on the properties of recycled PET/HDPE nanocomposites
- Three-dimensional viscoelastic simulation of the effect of wall slip on encapsulation in the coextrusion process
- Studies on thin films of PVC-PMMA blend polymer electrolytes
- Morphological study of PVDF/PMMA/TiO2 blend films prepared by melt casting process
- Effects of calcium stearate and metal hydroxide additions on the irradiated LDPE/EVA compound properties
- Preparation of poly(sebacic anhydride) and polylactic acid pills used as drug carrier for levofloxacin controlled release
- Gray optimization of process parameters of surface modification of coconut sheath reinforced polymer composites
