Preparation of poly(sebacic anhydride) and polylactic acid pills used as drug carrier for levofloxacin controlled release
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Zhuan Zhang
,
Jie Gao
Abstract
A biodegradable local drug release system consisting of poly(sebacic anhydride) and polylactic acid was developed for the purpose of osteomyelitis therapy. Five kinds of poly(sebacic anhydride) with different molecular weights were synthesized, and levofloxacin was chosen as a model antibacterial drug in the in vitro release within 38 days. As the molecular weight of poly(sebacic anhydride) increased, the melting point (Tm) of the matrices increased and the surface morphology became smoother. Consequently, the initial burst effect was reduced and the release rate significantly decreased. In addition, the kinetics of pills containing poly(sebacic anhydride) (Mw=13,000) were close to zero order release. The release profile reveals that the thermodynamic properties and morphology of these matrices, which are affected by the molecular weight, are essential for developing controllable delivery systems. The drug release rate could be easily controlled by the molecular weight of the poly(sebacic anhydride). Finally, these prospective results allow the biodegradable controlled release systems to be employed as carriers for the treatment of chronic osteomyelitis, as well as for other medical applications.
This work was supported by the Natural Science Foundation of Hubei Province (2000J052) and the Dominant Discipline’s Leader Project of Wuhan (20065006131-02).
References
[1] Huang JM, Wang WJ, Li BG, Zhu SP. Macromol. Mater. Eng. 2013, 298, 391–399.Suche in Google Scholar
[2] Nori A, Kopecek J. Adv. Drug Deliv. Rev. 2005, 57, 609–636.Suche in Google Scholar
[3] Ouimet MA, Griffin J, Carbone-Howell AL, Wu WH, Stebbins ND, Di R, Uhrich KE. Biomacromolecules 2013, 14, 854–861.10.1021/bm3018998Suche in Google Scholar
[4] Kim SH, Kim JW, Kim DH, Han SH, Weitz DA. Small 2013, 9, 124–131.10.1002/smll.201201709Suche in Google Scholar
[5] EI-Husseiny M, Patel S, Macfarlane RJ, Haddad FS. J. Bone Joint Surg. Br. 2011, 93, 151–157.Suche in Google Scholar
[6] Mendel V, Simanowski HJ, Scholz HC, Heymann H. Arch. Orthop. Trauma. Surg. 2005, 125, 363–368.Suche in Google Scholar
[7] Kanellakopoulou K, Giamarellos-Bourboulis EJ. Drugs 2000, 59, 1223–1232.10.2165/00003495-200059060-00003Suche in Google Scholar
[8] Cui L, Cohen JL, Chu CK, Wich PR, Kierstead PH, Frechet JMJ. J. Am. Chem. Soc. 2012, 134, 15840–15848.Suche in Google Scholar
[9] Tao CA, Wang JF, Qin SQ, Lv YA, Long Y, Jiang ZH. J. Mater. Chem. 2012, 22, 24856–24861.Suche in Google Scholar
[10] Zhang SD, Tao QH, Wang ZY, Zhang QP. J. Mater. Chem. 2012, 22, 20166–20169.Suche in Google Scholar
[11] Muthumanickkam A, Elankavi E, Gayathri R, Sampathkumar SK, Vijayakumar G, Muthukumar K, Subramanian S. Int. J. Mat. Res. 2010, 12, 1548–1553.Suche in Google Scholar
[12] Sahoo D, Nayak PL. Int. J. Mat. Res. 2012, 11, 1395–1399.Suche in Google Scholar
[13] Zhao HB, Cui ZX, Sun XF, Turng S, Peng XF. Ind. Eng. Chem. Res. 2013, 52, 2569–2581.Suche in Google Scholar
[14] Ray SS, Okamoto M. Prog. Polym. Sci. 2003, 28, 1539–1641.Suche in Google Scholar
[15] Kathryn EU. Chem. Rev. 1999, 99, 3181–3198.Suche in Google Scholar
[16] Domb AJ, Langer RS. J. Polym. Sci., Part A: Polym. Chem. 1987, 25, 3373–3386.Suche in Google Scholar
[17] Chen LB, Wang H, Shang L. J. Biomed. Mater. Res. Part B: Appl. Biomater. 2007, 83, 589–595.Suche in Google Scholar
[18] Gao J, Bao F, Feng LL, Shen KY, Zhu QD, Wang DF, Chen T, Ma R, Yan CJ. RSC Advances 2011, 1, 1737–1744.10.1039/c1ra00029bSuche in Google Scholar
[19] Wu CS, Liao HT. Polymer 2007, 48, 4449–4458.10.1016/j.polymer.2007.06.004Suche in Google Scholar
[20] Islam MS, Pickering KL, Foreman NJ. J. Polym. Environ. 2010, 18, 696–704.Suche in Google Scholar
[21] Gong K, Rehman IU, Darr JA. Int. J. Pharm. 2007, 338, 191–197.Suche in Google Scholar
[22] Day M, Victoria A, Liao X. J. Therm. Anal. Calorim. 2006, 86, 623–629.Suche in Google Scholar
[23] Mathiowitz E, Amato C, Dor P, Langer R. Polymer 1990, 31, 547–555.10.1016/0032-3861(90)90401-JSuche in Google Scholar
[24] Le CP, Estebe JP, Clement R, Du PL, Chevanne F, Ecoffey C, Le VR. Int. J. Pharm. 2002, 238, 191–203.Suche in Google Scholar
[25] Tisserat B, Finkenstadt. J. Polym. Environ. 2011, 19, 766–775.Suche in Google Scholar
[26] EI-Newehy MH, Elsherbiny AS, Mori H. J. Appl. Polym. Sci. 2013, 127, 4918–4926.Suche in Google Scholar
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- Preparation of poly(sebacic anhydride) and polylactic acid pills used as drug carrier for levofloxacin controlled release
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Artikel in diesem Heft
- Masthead
- Masthead
- Original articles
- Degradation of epoxidized natural rubber compatibilized linear low density polyethylene/ soya powder blends: the effect of natural weathering
- Effect of compatibilizing agents on the physical properties of iPP/HDPE organoclay blends
- Thermal and mechanical properties of ultrahigh molecular weight polyethylene/high-density polyethylene/polyethylene glycol blends
- Effect of MMT concentrations as reinforcement on the properties of recycled PET/HDPE nanocomposites
- Three-dimensional viscoelastic simulation of the effect of wall slip on encapsulation in the coextrusion process
- Studies on thin films of PVC-PMMA blend polymer electrolytes
- Morphological study of PVDF/PMMA/TiO2 blend films prepared by melt casting process
- Effects of calcium stearate and metal hydroxide additions on the irradiated LDPE/EVA compound properties
- Preparation of poly(sebacic anhydride) and polylactic acid pills used as drug carrier for levofloxacin controlled release
- Gray optimization of process parameters of surface modification of coconut sheath reinforced polymer composites
