Startseite New half sandwich complexes of ruthenium(ii) and iridium(iii). Study of their toxicity against Hela
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New half sandwich complexes of ruthenium(ii) and iridium(iii). Study of their toxicity against Hela

  • Alfonso Canales-Martínez , Rosa M. Pérez-Pastor und Gabriel García ORCID logo EMAIL logo
Veröffentlicht/Copyright: 12. Juli 2024
Pure and Applied Chemistry
Aus der Zeitschrift Pure and Applied Chemistry Band 96 Heft 12

Abstract

In this work, we describe the synthesis and characterisation of the starting materials [Cp*IrCl2]2 and four new ruthenium(II) and iridium(III) complexes half sandwich, contain the fragments [(p-cymene)Ru]2+ and [Cp*Ir]2+; (Cp* = CpMe4Et) of stoichiometry: [Cp*IrCl2(2-aminopyridine)] (I), [Cp*IrCl2(4-aminopyridine)] (II), [Cp*IrCl2(adenine)] (III) and [(p-cymene)RuCl2(adenine)] (IV). The new compounds have been characterised by C, H, and N elemental analysis; infrared and 1H NMR spectroscopy with 1H–1H COSY, ESI/TOF mass spectrometry and thermogravimetry. A study of the cytotoxicity of these compounds against the Hela cell line was carried out, with results indicating a low activity.

Keywords: anticancer activity; cytotoxicity; Hela; MTT assay; ruthenium and iridium complexes
Corresponding author: Gabriel García, Departamento de Química Inorgánica, Facultad de Química, Campus Regional de Excelencia, “Campus Mare Nostrum”, Universidad de Murcia, 30071, Murcia, Spain, e-mail:

Funding source: Ministerio de Ciencia e Innovación

Award Identifier / Grant number: 10.13039/501100011033

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/pac-2024-0224).

Published Online: 2024-07-12
Published in Print: 2024-12-17

© 2024 IUPAC & De Gruyter

Artikel in diesem Heft

  1. Frontmatter
  2. In this issue
  3. IUPAC Recommendations
  4. Definition of materials chemistry (IUPAC Recommendations 2024)
  5. Research Articles
  6. Positional microstates and probability fields in real systems
  7. Synthesis, characterization and antioxidant screening of a 1,10-phenanthroline-based tetraza-macrocyclic ligand and its nickel complex with therapeutic potential and catalytic significance
  8. Comprehensive evaluation of physical properties and carbon dioxide capacities of new 2-(butylamino)ethanol-based deep eutectic solvents
  9. Comprehensive evaluation of the impact of ionic liquid incorporation on the optical properties, Urbach energy, thin film morphology, and surface roughness of poly(vinyl chloride) based on ionic materials
  10. The impact of nanofiller composition and nature on the enhancement of mechanical and rheological properties of poly(lactic acid) (PLA) nanobiocomposite films is achieved by regulating the spacing of organic fillers and PLA crystallinity
  11. The case of the disappearing energy: potential energies in concentration gradients
  12. Removal of metaldehyde pesticide from aquatic media using modified cellulose obtained from Populus nigra plant, as potential adsorbent
  13. New half sandwich complexes of ruthenium(ii) and iridium(iii). Study of their toxicity against Hela
https://doi.org/10.1515/pac-2024-0224
Schlagwörter für diesen Artikel
anticancer activity; cytotoxicity; Hela; MTT assay; ruthenium and iridium complexes

Artikel in diesem Heft

  1. Frontmatter
  2. In this issue
  3. IUPAC Recommendations
  4. Definition of materials chemistry (IUPAC Recommendations 2024)
  5. Research Articles
  6. Positional microstates and probability fields in real systems
  7. Synthesis, characterization and antioxidant screening of a 1,10-phenanthroline-based tetraza-macrocyclic ligand and its nickel complex with therapeutic potential and catalytic significance
  8. Comprehensive evaluation of physical properties and carbon dioxide capacities of new 2-(butylamino)ethanol-based deep eutectic solvents
  9. Comprehensive evaluation of the impact of ionic liquid incorporation on the optical properties, Urbach energy, thin film morphology, and surface roughness of poly(vinyl chloride) based on ionic materials
  10. The impact of nanofiller composition and nature on the enhancement of mechanical and rheological properties of poly(lactic acid) (PLA) nanobiocomposite films is achieved by regulating the spacing of organic fillers and PLA crystallinity
  11. The case of the disappearing energy: potential energies in concentration gradients
  12. Removal of metaldehyde pesticide from aquatic media using modified cellulose obtained from Populus nigra plant, as potential adsorbent
  13. New half sandwich complexes of ruthenium(ii) and iridium(iii). Study of their toxicity against Hela
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