Artikel
Lizenziert
Nicht lizenziert
Erfordert eine Authentifizierung
Clinical significance of serum sRAGE and esRAGE in women with normal pregnancy and preeclampsia
-
Jae-Hyun Kwon
,
Ja-Young Kwon
Veröffentlicht/Copyright:
18. Juli 2011
Abstract
Background: We determined serum endogenous secretory receptor of advanced glycation end products (esRAGE) and soluble RAGE (sRAGE) concentrations and the esRAGE/sRAGE ratio in normal pregnancy and preeclampsia because esRAGE and sRAGE have been negatively linked to components of metabolic syndromes and pathologic pregnancy including preeclampsia.
Method: Eighty-seven normal pregnant women and 28 with preeclampsia were recruited. Serum sRAGE and esRAGE levels were measured by enzyme-linked immunosorbent assay.
Results: There were significant differences in esRAGE concentration and esRAGE/sRAGE ratio between 1st and 3rd trimester in normal pregnancy (P=0.007 and P=0.003). Serum esRAGE concentrations and esRAGE/sRAGE ratio in patients with preeclampsia significantly increased compared to controls (P=0.005 and P<0.001).
Conclusions: Maternal serum esRAGE concentration and esRAGE/sRAGE ratio (1) gradually decrease with gestational age in normal pregnancy; and (2) are higher in patients with preeclampsia than healthy pregnant controls, significantly. Serum esRAGE and esRAGE/sRAGE ratio might be associated with preeclampsia.
Received: 2010-11-9
Revised: 2011-2-17
Accepted: 2011-3-15
Published Online: 2011-07-18
Published Online: 2011-07-19
Published in Print: 2011-09-01
©2011 by Walter de Gruyter Berlin Boston
Sie haben derzeit keinen Zugang zu diesem Inhalt.
Sie haben derzeit keinen Zugang zu diesem Inhalt.
Artikel in diesem Heft
- Review article
- Neonatal outcomes of assisted and naturally conceived twins: systematic review and meta-analysis
- Original articles – Obstetrics
- Postpartum hemorrhage in low risk population
- Perinatal mortality in preterm births: an analysis of causes, presence of substandard care and avoiding mortality in three Dutch regions
- Clinical significance of serum sRAGE and esRAGE in women with normal pregnancy and preeclampsia
- Biopsychosocial predictors of preterm delivery
- Maternal preeclampsia is associated with an increased risk of retinopathy of prematurity
- Original articles – Fetus
- Natriuretic peptide levels in intrauterine growth-restricted fetuses with absent and reversed end-diastolic flow of the umbilical artery in relation to ductus venosus flow velocities
- Inter- and intra-observer variation of fetal volume measurements with three-dimensional ultrasound in the first trimester of pregnancy
- Outcome of severe intrapartum acidemia diagnosed with fetal scalp blood sampling
- Comparison of global and regional right and left ventricular longitudinal peak systolic strain, strain rate and velocity in healthy fetuses using a novel feature tracking technique
- Contribution of twin-to-twin transfusion syndrome to preterm birth among monochorionic biamniotic and bichorionic biamniotic twin pregnancies
- Original articles – Newborn
- Historical notes on immaturity. Part 1: Measures of viability
- Historical notes on immaturity. Part 2: Surviving against the odds
- Head circumference catch-up growth among preterm very low birth weight infants: effect on neurodevelopmental outcome
- Energy metabolism in umbilical endothelial cells from preterm and term neonates
- Decision-making at the border of viability by means of values clarification: a case study to achieve distinct communication by ordinary language approach
- Neonatal morbidity in term neonates is related to gestational age at birth and level of care
- Letters to the Editor
- Effect of steroids on angiogenic factors in pregnant women with HELLP syndrome
- Acute neonatal respiratory morbidity after prior cesarean
- Congress calendar
- Congress Calendar
Artikel in diesem Heft
- Review article
- Neonatal outcomes of assisted and naturally conceived twins: systematic review and meta-analysis
- Original articles – Obstetrics
- Postpartum hemorrhage in low risk population
- Perinatal mortality in preterm births: an analysis of causes, presence of substandard care and avoiding mortality in three Dutch regions
- Clinical significance of serum sRAGE and esRAGE in women with normal pregnancy and preeclampsia
- Biopsychosocial predictors of preterm delivery
- Maternal preeclampsia is associated with an increased risk of retinopathy of prematurity
- Original articles – Fetus
- Natriuretic peptide levels in intrauterine growth-restricted fetuses with absent and reversed end-diastolic flow of the umbilical artery in relation to ductus venosus flow velocities
- Inter- and intra-observer variation of fetal volume measurements with three-dimensional ultrasound in the first trimester of pregnancy
- Outcome of severe intrapartum acidemia diagnosed with fetal scalp blood sampling
- Comparison of global and regional right and left ventricular longitudinal peak systolic strain, strain rate and velocity in healthy fetuses using a novel feature tracking technique
- Contribution of twin-to-twin transfusion syndrome to preterm birth among monochorionic biamniotic and bichorionic biamniotic twin pregnancies
- Original articles – Newborn
- Historical notes on immaturity. Part 1: Measures of viability
- Historical notes on immaturity. Part 2: Surviving against the odds
- Head circumference catch-up growth among preterm very low birth weight infants: effect on neurodevelopmental outcome
- Energy metabolism in umbilical endothelial cells from preterm and term neonates
- Decision-making at the border of viability by means of values clarification: a case study to achieve distinct communication by ordinary language approach
- Neonatal morbidity in term neonates is related to gestational age at birth and level of care
- Letters to the Editor
- Effect of steroids on angiogenic factors in pregnant women with HELLP syndrome
- Acute neonatal respiratory morbidity after prior cesarean
- Congress calendar
- Congress Calendar
