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Gestational diabetes mellitus complicating twin pregnancies
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Teresinha Simões
Published/Copyright:
July 1, 2011
Abstract
Objective: To compare outcomes of twin pregnancies with and without gestational diabetes mellitus (GDM).
Study design: We compared 105 twin pregnancies with GDM (7.8% of all twin pregnancies) to 315 controls without GDM, matched for gestational age, chorionicity and year of birth.
Results: Pre-gravid obesity appears to predispose women to GDM during twin pregnancy [odds ratio (OR) 3.5; 95% confidence interval (CI) 1.7, 7.0]. Overweight and obese women that subsequently developed GDM during their twin gestation were less likely to conceive spontaneously (OR 0.4; 95% CI 0.3, 0.7). Twins from the GDM group had more respiratory distress syndrome (RDS, OR 2.2; 95% CI 1.3, 3.7) and had a three-fold, but not significantly increased perinatal mortality rate. Birth weight characteristics were similar in both groups.
Conclusion: Twin pregnancies complicated by GDM might be associated with pre-pregnancy maternal obesity and are at increased risk of RDS and non-significant increased risk of perinatal death.
Received: 2011-1-8
Revised: 2011-2-18
Accepted: 2011-2-24
Published Online: 2011-07-01
Published in Print: 2011-07-01
©2011 by Walter de Gruyter Berlin Boston
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Keywords for this article
Gestational diabetes;
obesity;
respiratory distress syndrome;
twin pregnancy
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