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Bridging global gene expression candidates in first trimester placentas with susceptibility loci from linkage studies of preeclampsia
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Sandra A. Founds
Published/Copyright:
June 22, 2011
Abstract
Preeclampsia is as a leading cause of maternal and perinatal morbidity and mortality. Prevention, early identification, and individualized treatments may become feasible if reliable early biomarkers can be developed. Towards a systems biology framework, this review synthesizes prior linkage studies and genome scans of preeclampsia with candidates identified in a global gene expression microarray analysis of chorionic villus sampling (CVS) specimens from women who sub-sequently developed preeclampsia. Nearly 40% of these CVS candidate genes occurred in previously identified susceptibility loci for preeclampsia. Integration of genetic epidemiologic and functional gene expression data could help to elucidate preeclampsia as a complex disease resulting from multiple maternal and fetal/placental factors that each contributes a greater or lesser effect. These loci and related candidate genes are set to substantially improve insights into the first trimester pathogenesis of this pregnancy disorder.
Keywords: Genetical genomics; global gene expression microarray; linkage; positional candidates; systems biology
Received: 2010-11-22
Revised: 2011-1-16
Accepted: 2011-2-7
Published Online: 2011-06-22
Published Online: 2011-06-22
Published in Print: 2011-07-01
©2011 by Walter de Gruyter Berlin Boston
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- Bridging global gene expression candidates in first trimester placentas with susceptibility loci from linkage studies of preeclampsia
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- Congress calendar
- Congress Calendar
Keywords for this article
Genetical genomics;
global gene expression microarray;
linkage;
positional candidates;
systems biology
Articles in the same Issue
- Review articles
- Bridging global gene expression candidates in first trimester placentas with susceptibility loci from linkage studies of preeclampsia
- Candidates for the determination of antithrombin activity in pregnant women
- Opinion paper
- Using prophylactic, but not tocolytic, magnesium sulfate to reduce cerebral palsy related to prematurity: what dose, and what about infant mortality?
- Original articles – Obstetrics
- Vaginal breech delivery in very low birth weight (VLBW) neonates: experience of a single center
- Fetal outcome for infants in breech by method of delivery: experiences with a stand-by service system of senior obstetricians and women's choices of mode of delivery
- Characterization of discriminatory urinary proteomic biomarkers for severe preeclampsia using SELDI-TOF mass spectrometry
- Oxytocin versus dinoprostone vaginal insert for induction of labor after previous cesarean section: a retrospective comparative study
- Mid-trimester amniotic fluid concentrations of the proinflammatory cytokines IL-6, IL-8, TNF-α, and lipopolysaccharide binding protein in normal pregnancies: a prospective evaluation according to parity, gestational age, and fetal gender
- Expression of laminin receptor 1 in human placentas from normal and preeclamptic pregnancies and its relationship with the severity of preeclampsia
- Colonization, serotypes and transmission rates of group B streptococci in pregnant women and their infants born at a single University Center in Germany
- The placental factor in spontaneous preterm labor with and without premature rupture of membranes
- A 29-gauge atraumatic needle for amniocentesis
- Gestational diabetes mellitus complicating twin pregnancies
- Original articles – Fetus
- Results of and further prevention of hypoxic fetal brain damage by inhibition of xanthine oxidase enzyme with allopurinol
- Diastolic forward flow in the fetal main pulmonary artery and its implication for fetal cardiac cycle evaluation
- Abnormalities of the penis in utero – hypospadias on fetal MRI
- Intrapartum cardiotocography (CTG) and ST-analysis of labor in diabetic patients
- Original articles – Newborn
- Ductus venosus flow at 11–13 weeks in the prediction of birth weight discordance in monochorionic twins
- Stability of thyroid hormones during continuous infusion
- Short communication
- Supracervical cerclage with intracavitary balloon to control bleeding associated with placenta previa
- Letter to the Editor
- Two cases of Lowe syndrome presenting as increased fetal nuchal translucency
- Congress calendar
- Congress Calendar
