Article
Licensed
Unlicensed
Requires Authentication
Expression of laminin receptor 1 in human placentas from normal and preeclamptic pregnancies and its relationship with the severity of preeclampsia
-
Mertihan Kurdoglu
,
Zehra Kurdoglu
Published/Copyright:
March 11, 2011
Abstract
Objectives: To investigate the expression of laminin receptor 1 (LR1), a non-integrin-type laminin receptor, in preeclamptic and normal third-trimester placentas, as well as to investigate whether its expression differs with disease severity.
Study design: Third trimester placental samples obtained from deliveries of preeclamptic (n=34) and normotensive healthy pregnant women (n=35) were immunohistochemically studied for the expression of LR1. The placentas from both mild (n=14) and severe (n=20) preeclamptic pregnancies were further assessed for strength of LR1 expression according to disease severity.
Results: When compared with normal placentas, the staining with LR1 protein in cytotrophoblasts and syncytiotrophoblasts was lower in preeclamptic placentas (P<0.05 and P<0.01, respectively). The intensity of staining with LR1 in decidual cells, cytotrophoblasts, syncytiotrophoblasts, and extracellular matrix cells of preeclamptic placentas did not vary with disease severity (P>0.05).
Conclusions: Decreased LR1 expression in cytotrophoblasts and syncytiotrophoblasts of preeclamptic placentas, which may be independent of disease severity, might have a role in shallow trophoblastic invasion in preeclampsia.
Received: 2010-8-26
Revised: 2010-11-16
Accepted: 2010-11-23
Published Online: 2011-03-11
Published Online: 2011-03-11
Published in Print: 2011-07-01
©2011 by Walter de Gruyter Berlin Boston
You are currently not able to access this content.
You are currently not able to access this content.
Articles in the same Issue
- Review articles
- Bridging global gene expression candidates in first trimester placentas with susceptibility loci from linkage studies of preeclampsia
- Candidates for the determination of antithrombin activity in pregnant women
- Opinion paper
- Using prophylactic, but not tocolytic, magnesium sulfate to reduce cerebral palsy related to prematurity: what dose, and what about infant mortality?
- Original articles – Obstetrics
- Vaginal breech delivery in very low birth weight (VLBW) neonates: experience of a single center
- Fetal outcome for infants in breech by method of delivery: experiences with a stand-by service system of senior obstetricians and women's choices of mode of delivery
- Characterization of discriminatory urinary proteomic biomarkers for severe preeclampsia using SELDI-TOF mass spectrometry
- Oxytocin versus dinoprostone vaginal insert for induction of labor after previous cesarean section: a retrospective comparative study
- Mid-trimester amniotic fluid concentrations of the proinflammatory cytokines IL-6, IL-8, TNF-α, and lipopolysaccharide binding protein in normal pregnancies: a prospective evaluation according to parity, gestational age, and fetal gender
- Expression of laminin receptor 1 in human placentas from normal and preeclamptic pregnancies and its relationship with the severity of preeclampsia
- Colonization, serotypes and transmission rates of group B streptococci in pregnant women and their infants born at a single University Center in Germany
- The placental factor in spontaneous preterm labor with and without premature rupture of membranes
- A 29-gauge atraumatic needle for amniocentesis
- Gestational diabetes mellitus complicating twin pregnancies
- Original articles – Fetus
- Results of and further prevention of hypoxic fetal brain damage by inhibition of xanthine oxidase enzyme with allopurinol
- Diastolic forward flow in the fetal main pulmonary artery and its implication for fetal cardiac cycle evaluation
- Abnormalities of the penis in utero – hypospadias on fetal MRI
- Intrapartum cardiotocography (CTG) and ST-analysis of labor in diabetic patients
- Original articles – Newborn
- Ductus venosus flow at 11–13 weeks in the prediction of birth weight discordance in monochorionic twins
- Stability of thyroid hormones during continuous infusion
- Short communication
- Supracervical cerclage with intracavitary balloon to control bleeding associated with placenta previa
- Letter to the Editor
- Two cases of Lowe syndrome presenting as increased fetal nuchal translucency
- Congress calendar
- Congress Calendar
Articles in the same Issue
- Review articles
- Bridging global gene expression candidates in first trimester placentas with susceptibility loci from linkage studies of preeclampsia
- Candidates for the determination of antithrombin activity in pregnant women
- Opinion paper
- Using prophylactic, but not tocolytic, magnesium sulfate to reduce cerebral palsy related to prematurity: what dose, and what about infant mortality?
- Original articles – Obstetrics
- Vaginal breech delivery in very low birth weight (VLBW) neonates: experience of a single center
- Fetal outcome for infants in breech by method of delivery: experiences with a stand-by service system of senior obstetricians and women's choices of mode of delivery
- Characterization of discriminatory urinary proteomic biomarkers for severe preeclampsia using SELDI-TOF mass spectrometry
- Oxytocin versus dinoprostone vaginal insert for induction of labor after previous cesarean section: a retrospective comparative study
- Mid-trimester amniotic fluid concentrations of the proinflammatory cytokines IL-6, IL-8, TNF-α, and lipopolysaccharide binding protein in normal pregnancies: a prospective evaluation according to parity, gestational age, and fetal gender
- Expression of laminin receptor 1 in human placentas from normal and preeclamptic pregnancies and its relationship with the severity of preeclampsia
- Colonization, serotypes and transmission rates of group B streptococci in pregnant women and their infants born at a single University Center in Germany
- The placental factor in spontaneous preterm labor with and without premature rupture of membranes
- A 29-gauge atraumatic needle for amniocentesis
- Gestational diabetes mellitus complicating twin pregnancies
- Original articles – Fetus
- Results of and further prevention of hypoxic fetal brain damage by inhibition of xanthine oxidase enzyme with allopurinol
- Diastolic forward flow in the fetal main pulmonary artery and its implication for fetal cardiac cycle evaluation
- Abnormalities of the penis in utero – hypospadias on fetal MRI
- Intrapartum cardiotocography (CTG) and ST-analysis of labor in diabetic patients
- Original articles – Newborn
- Ductus venosus flow at 11–13 weeks in the prediction of birth weight discordance in monochorionic twins
- Stability of thyroid hormones during continuous infusion
- Short communication
- Supracervical cerclage with intracavitary balloon to control bleeding associated with placenta previa
- Letter to the Editor
- Two cases of Lowe syndrome presenting as increased fetal nuchal translucency
- Congress calendar
- Congress Calendar
