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The source of error in the estimation of intertwin birth weight discordance
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Maria Augusta Reberdao
Published/Copyright:
August 13, 2010
Abstract
Objective: To assess the accuracy of paired estimated fetal weights (EFWs) to predict three levels of twin birth weight discordance (>15%, >20% and >25%).
Method: A cohort of twin pairs underwent ultrasound examinations within 2 weeks from birth. We calculated the frequency of under- and overestimation of the actual birth weight (< or >10%, respectively) in the entire cohort as well in the subset of mono- and dichorionic pairs.
Results: Discordance was largely underestimated (observed 10.4±0.8% compared to actual 19.2±1.1%, P=0.001) because the larger twin was more frequently underestimated [30.6 vs. 17.7%, odds ratio (OR) 2.0, 95% confidence interval (CI) 1.1, 3.9 in the entire cohort, and 34.2 vs. 13.1%, OR 3.4, 95% CI 1.4, 8.4 in the dichorionic pairs]. Overall, the specificity for detecting the three levels of discordance was adequate (91.5–94.2%) but the sensitivity was poor (11.1–17.8%) and tended to decrease with increasing discordance level.
Conclusion: The poor ability of paired EFWs to diagnose birth weight discordance results from underestimation of the larger twin.
Received: 2010-3-15
Revised: 2010-5-17
Accepted: 2010-6-7
Published Online: 2010-08-13
Published Online: 2010-08-13
Published in Print: 2010-11-01
©2010 by Walter de Gruyter Berlin New York
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Keywords for this article
Birth weight discordance;
chorionicity;
estimated fetal weight;
twins;
ultrasound
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- Review article
- Oxygen and oxidative stress in bronchopulmonary dysplasia
- A statement of the World Association of Perinatal Medicine
- Ethical dimensions of periviability
- Opinion Paper
- The role of melatonin in post-partum psychosis and depression associated with bipolar disorder
- Original articles – Obstetrics
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- Comparison of complications in second trimester amniocentesis performed with 20G, 21G and 22G needles
- Genome profiles in maternal blood during early onset preeclampsia and towards term
- Comparative analysis of insulin-like growth factor binding protein-1 (IGFBP-1), placental alpha-microglobulin-1 (PAMG-1) and nitrazine test to diagnose premature rupture of membranes in pregnancy
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