Retrospective comparison of monochorionic diamniotic twin pregnancies stratified by spontaneous or artificial conception

Sofia Roero; Silvana Arduino; Arianna Arese; Teresa Fea; Isabella Ferrando; Gabriella Scaltrito; Viola Casula; Alice Ronco; Carlotta Bossotti; Roberto Zizzo; Roberto Scali; Alberto Revelli

doi:10.1515/jpm-2023-0078

Article

Retrospective comparison of monochorionic diamniotic twin pregnancies stratified by spontaneous or artificial conception

Sofia Roero , Silvana Arduino , Arianna Arese , Teresa Fea , Isabella Ferrando , Gabriella Scaltrito , Viola Casula , Alice Ronco , Carlotta Bossotti , Roberto Zizzo , Roberto Scali and Alberto Revelli

Published/Copyright: July 26, 2023

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From the journal Journal of Perinatal Medicine Volume 51 Issue 8

Abstract

Objectives

To compare outcomes of monochorionic diamniotic (MCDA) twin pregnancies by in vitro fertilization (IVF) vs. spontaneously conceived counterparts.

Methods

Retrospective comparison. Data about MCDA twin pregnancies, conceived spontaneously or by IVF, attending the Twin Pregnancy Care Unit of Sant’Anna Hospital in Turin (Italy) between January 1st 2010 and March 31st 2022, were collected retrospectively. Obstetric, fetal, and neonatal outcomes of MCDA twin pregnancies by IVF were compared to those of spontaneously conceived counterparts. Data were described by univariate and multivariate analysis.

Results

541 MCDA twin pregnancies were included in the study, among which 45 conceived by IVF and 496 spontaneously conceived. Women with IVF twins were older than those who conceived spontaneously (36.7 ± 5.7 vs. 32.1 ± 5.2 years; p<0.001). No significant difference in the prevalence of pregnancy complications between the two groups was found, except for an increased incidence of hypertensive disorders among IVF pregnancies (17.8 vs. 8.5 %; p=0.039), which resulted nonsignificant after adjusting for maternal age and parity (aOR 1.9, 95 % CI 0.8–4.6). Data about 1,046 live born babies (90 conceived by IVF and 956 spontaneously) were also collected: perinatal outcomes did not differ between the two groups.

Conclusions

Our results suggest that MCDA twin pregnancies following IVF are not at increased risk of adverse outcomes compared to spontaneous MCDA twin pregnancies.

Keywords: IVF; monochorionic twin pregnancy; neonatal outcomes; obstetric outcomes; pregnancy complications

Corresponding author: Sofia Roero, MD, Twin Pregnancy Care Unit, Gynecology and Obstetrics 2U, A.O.U. Città della Salute e della Scienza, Sant’Anna Obstetric Gynecological Hospital, University of Torino, Corso Spezia 60, 10126, Torino, Italy, Phone: +39 366 1960241, E-mail: sofia.roero@unito.it

Research funding: None declared.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: Research involving human subjects complied with all relevant national regulations, institutional policies and is in accordance with the tenets of the Helsinki Declaration (as revised in 2013), and the study has been deemed exempt from review.
Data availability: The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Received: 2023-02-22

Accepted: 2023-06-24

Published Online: 2023-07-26

Published in Print: 2023-10-26

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Articles in the same Issue

https://doi.org/10.1515/jpm-2023-0078

Keywords for this article

IVF; monochorionic twin pregnancy; neonatal outcomes; obstetric outcomes; pregnancy complications