Startseite Cervical strain elastography: pattern analysis and cervical sliding sign in preterm and control pregnancies
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Cervical strain elastography: pattern analysis and cervical sliding sign in preterm and control pregnancies

  • Bianca Debring EMAIL logo , Mareike Möllers , Helen A. Köster , Robert Kwiecien , Janina Braun , Kathrin Oelmeier , Walter Klockenbusch und Ralf Schmitz EMAIL logo
Veröffentlicht/Copyright: 16. August 2022
Journal of Perinatal Medicine
Aus der Zeitschrift Journal of Perinatal Medicine Band 51 Heft 3

Abstract

Objectives

The aim of this study was to assess the value of cervical strain elastography and Cervical Sliding Sign (CSS) for predicting spontaneous preterm birth (sPTB).

Methods

In our case-control study we performed an elastographic assessment of the cervix in 82 cases of preterm birth (preterm group) and 451 control pregnancies (control group) between the 20th and 37th week of gestation. We divided the anterior cervical lip first into two (“Intern2”, “Extern2”) and into three sectors (“Intern3”, “Middle3”, “Extern3”). The tissue deformation pattern after local compression with an ultrasound probe was recorded. We distinguished between an irregularly distributed (“Spotting”) and homogeneous pattern presentation. Additionally, the presence of a sliding of the anterior against the posterior cervical lip (positive CSS) during compression was evaluated. A logistic regression analysis and the Akaike Information Criterion (AIC) were used to estimate the probability of sPTB and to select a prediction model.

Results

Spotting and positive CSS occurred more frequently in the preterm group compared to control group (97.8 vs. 2.2%, p<0.001; 26.8 vs. 4.2%, p<0.001; respectively). The model with the parameters week of gestation at ultrasound examination, Intern3, Middle3 and CSS was calculated as the highest quality model for predicting sPTB. The AUC (Area Under the Curve) was higher for this parameter combination compared to cervical length (CL) (0.926 vs. 0.729).

Conclusions

Cervical strain elastography pattern analysis may be useful for the prediction of sPTB, as the combination of Spotting analysis and CSS is superior to CL measurement alone.

Keywords: cervical length; cervix; pregnancy; preterm birth; sliding sign; strain elastography; ultrasound
Corresponding authors: Bianca Debring and Prof. Dr. Ralf Schmitz, MD, Department of Gynecology and Obstetrics, University Hospital of Münster, Albert-Schweitzer-Campus 1, 48149 Münster, Germany, Phone: +49 2518348212, Fax: +49 2518348210, E-mail: ,

Acknowledgments

We thank everyone who voluntarily dedicated their time and effort.

  1. Research funding: None declared.

  2. Author contributions: B. Debring: data collection, data management, data analysis, manuscript writing. M. Möllers: data collection, manuscript editing. H.A. Köster: scientific consulting, manuscript editing. R. Kwiecien: statistics, manuscript editing. J. Braun: data collection, manuscript editing. K. Oelmeier: data collection, manuscript editing. W. Klockenbusch: data collection, manuscript editing. R. Schmitz: project construction, data collection, manuscript revision. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individual participants included in the study.

  5. Ethical approval: The study was designed according to the Declaration of Helsinki and was approved by the Institutional Ethics Board (2010-256-f-S and 2015-649-f-S).

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Received: 2022-03-26
Accepted: 2022-07-10
Published Online: 2022-08-16
Published in Print: 2023-03-28

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. A Celebration of Professor Joachim Dudenhausen
  4. Reviews
  5. Gestational complications associated with SARS-CoV-2 infection in pregnant women during 2020–2021: systematic review of longitudinal studies
  6. Eclampsia a preventable tragedy: an African overview
  7. Original Articles – Obstetrics
  8. How do bicornuate uteri alter pregnancy, intra-partum and neonatal risks? A population based study of more than three million deliveries and more than 6000 bicornuate uteri
  9. Maternal urogenital infection and fetal heart functional assessment – what is the missing link?
  10. Knowledge and attitudes of pregnant women on maternal immunization against COVID-19 in Croatia
  11. Retrospective review of GCT cutoff value based on pre-pregnancy BMI class in patients with GDM
  12. Cervical strain elastography: pattern analysis and cervical sliding sign in preterm and control pregnancies
  13. Maternal race/ethnicity impacts the success rates of external cephalic version (ECV) in the United States
  14. Fetal adrenal gland size and umbilical artery Doppler in growth-restricted fetuses
  15. Counseling pregnant women on calcium: effects on calcium intake
  16. Relationship among anogenital distance, adrenal gland volume, and penile length and width at 22–36 weeks of pregnancy
  17. Intra-amniotic inflammation in the mid-trimester of pregnancy is a risk factor for neuropsychological disorders in childhood
  18. Genetic amniocentesis using atraumatic 29 gauge needle in patients having a chorioamniotic separation
  19. YouTube as a source of patient information on external cephalic version
  20. Midwives’ personal and professional attitudes towards women’s delivery choices, interventions and neonatal care
  21. Maternal serum midkine level in fetal growth restriction: a case-control study
  22. Original Articles – Neonates
  23. Interventions for reducing late-onset sepsis in neonates: an umbrella review
  24. Maternal knowledge of recommendations for safe infant sleep and intentions for implementation – a cross sectional analysis of data from the KUNO-Kids birth cohort study
  25. Short Communication
  26. Lysophosphatidylcholine acyltransferase 1 protein is present in maternal blood in the third trimester and is upregulated by antenatal corticosteroids
  27. Letters to the Editor
  28. Peripartum hysterectomy at a tertiary university perinatal center – retrospective analysis of the 25-year period
  29. Neonate, infected mother and monkeypox: the present concern
https://doi.org/10.1515/jpm-2022-0166
Schlagwörter für diesen Artikel
cervical length; cervix; pregnancy; preterm birth; sliding sign; strain elastography; ultrasound

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. A Celebration of Professor Joachim Dudenhausen
  4. Reviews
  5. Gestational complications associated with SARS-CoV-2 infection in pregnant women during 2020–2021: systematic review of longitudinal studies
  6. Eclampsia a preventable tragedy: an African overview
  7. Original Articles – Obstetrics
  8. How do bicornuate uteri alter pregnancy, intra-partum and neonatal risks? A population based study of more than three million deliveries and more than 6000 bicornuate uteri
  9. Maternal urogenital infection and fetal heart functional assessment – what is the missing link?
  10. Knowledge and attitudes of pregnant women on maternal immunization against COVID-19 in Croatia
  11. Retrospective review of GCT cutoff value based on pre-pregnancy BMI class in patients with GDM
  12. Cervical strain elastography: pattern analysis and cervical sliding sign in preterm and control pregnancies
  13. Maternal race/ethnicity impacts the success rates of external cephalic version (ECV) in the United States
  14. Fetal adrenal gland size and umbilical artery Doppler in growth-restricted fetuses
  15. Counseling pregnant women on calcium: effects on calcium intake
  16. Relationship among anogenital distance, adrenal gland volume, and penile length and width at 22–36 weeks of pregnancy
  17. Intra-amniotic inflammation in the mid-trimester of pregnancy is a risk factor for neuropsychological disorders in childhood
  18. Genetic amniocentesis using atraumatic 29 gauge needle in patients having a chorioamniotic separation
  19. YouTube as a source of patient information on external cephalic version
  20. Midwives’ personal and professional attitudes towards women’s delivery choices, interventions and neonatal care
  21. Maternal serum midkine level in fetal growth restriction: a case-control study
  22. Original Articles – Neonates
  23. Interventions for reducing late-onset sepsis in neonates: an umbrella review
  24. Maternal knowledge of recommendations for safe infant sleep and intentions for implementation – a cross sectional analysis of data from the KUNO-Kids birth cohort study
  25. Short Communication
  26. Lysophosphatidylcholine acyltransferase 1 protein is present in maternal blood in the third trimester and is upregulated by antenatal corticosteroids
  27. Letters to the Editor
  28. Peripartum hysterectomy at a tertiary university perinatal center – retrospective analysis of the 25-year period
  29. Neonate, infected mother and monkeypox: the present concern
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