Genetic amniocentesis using atraumatic 29 gauge needle in patients having a chorioamniotic separation
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Michael Tchirikov
,
Constanze Scheler
Abstract
Objectives
Chorioamniotic separation (CAS) at the time of standard amniocentesis (AC) is a risk factor for postprocedural complications and should be avoided. The aim of this study was to quantify procedure-related risks after AC with a 29G-needle in cases of CAS, and evaluation of perinatal outcome in CAS after 15 weeks’ gestation (GW).
Methods
Retrospective analysis of genetic AC with a pencil-point 29G needle after 15 completed GW in pregnancies, in which the fetal membranes were not yet fused. Included into the study were women aged 16–44 years with at least 15 completed GWs referred for second trimester AC to identify fetal chromosomal aberrations.
Results
437 ACs were made in total with the 29G-needle. The median maternal age was 30 (16–44) years. 145 cases showed CAS where the distance between chorion and amnion was 0.10–10.02 mm at AC. 38 pregnancies were terminated, 37 of which had a genetic disorder. The risk of aneuploidy increases by a factor of 2 (95% CI 1.4–2.8) for every 1 mm of CAS enlargement. No procedure-related complications were found up to two weeks after the AC.
Conclusions
CAS seems to be massively underreported. Early diagnosis in case of CAS is something to strive for as CAS could be an indicator of genetic abnormalities – a “soft marker”. With the atraumatic 29G needle, the risk of complications after AC in CAS seems to be very low.
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Research funding: None declared.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: The protocol for the intervention and data collection was approved by the Ethics Committee of Martin-Luther University Halle-Wittenberg, Germany. All the procedures were conducted according to the Helsinki Declaration.
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Articles in the same Issue
- Frontmatter
- Editorial
- A Celebration of Professor Joachim Dudenhausen
- Reviews
- Gestational complications associated with SARS-CoV-2 infection in pregnant women during 2020–2021: systematic review of longitudinal studies
- Eclampsia a preventable tragedy: an African overview
- Original Articles – Obstetrics
- How do bicornuate uteri alter pregnancy, intra-partum and neonatal risks? A population based study of more than three million deliveries and more than 6000 bicornuate uteri
- Maternal urogenital infection and fetal heart functional assessment – what is the missing link?
- Knowledge and attitudes of pregnant women on maternal immunization against COVID-19 in Croatia
- Retrospective review of GCT cutoff value based on pre-pregnancy BMI class in patients with GDM
- Cervical strain elastography: pattern analysis and cervical sliding sign in preterm and control pregnancies
- Maternal race/ethnicity impacts the success rates of external cephalic version (ECV) in the United States
- Fetal adrenal gland size and umbilical artery Doppler in growth-restricted fetuses
- Counseling pregnant women on calcium: effects on calcium intake
- Relationship among anogenital distance, adrenal gland volume, and penile length and width at 22–36 weeks of pregnancy
- Intra-amniotic inflammation in the mid-trimester of pregnancy is a risk factor for neuropsychological disorders in childhood
- Genetic amniocentesis using atraumatic 29 gauge needle in patients having a chorioamniotic separation
- YouTube as a source of patient information on external cephalic version
- Midwives’ personal and professional attitudes towards women’s delivery choices, interventions and neonatal care
- Maternal serum midkine level in fetal growth restriction: a case-control study
- Original Articles – Neonates
- Interventions for reducing late-onset sepsis in neonates: an umbrella review
- Maternal knowledge of recommendations for safe infant sleep and intentions for implementation – a cross sectional analysis of data from the KUNO-Kids birth cohort study
- Short Communication
- Lysophosphatidylcholine acyltransferase 1 protein is present in maternal blood in the third trimester and is upregulated by antenatal corticosteroids
- Letters to the Editor
- Peripartum hysterectomy at a tertiary university perinatal center – retrospective analysis of the 25-year period
- Neonate, infected mother and monkeypox: the present concern
Articles in the same Issue
- Frontmatter
- Editorial
- A Celebration of Professor Joachim Dudenhausen
- Reviews
- Gestational complications associated with SARS-CoV-2 infection in pregnant women during 2020–2021: systematic review of longitudinal studies
- Eclampsia a preventable tragedy: an African overview
- Original Articles – Obstetrics
- How do bicornuate uteri alter pregnancy, intra-partum and neonatal risks? A population based study of more than three million deliveries and more than 6000 bicornuate uteri
- Maternal urogenital infection and fetal heart functional assessment – what is the missing link?
- Knowledge and attitudes of pregnant women on maternal immunization against COVID-19 in Croatia
- Retrospective review of GCT cutoff value based on pre-pregnancy BMI class in patients with GDM
- Cervical strain elastography: pattern analysis and cervical sliding sign in preterm and control pregnancies
- Maternal race/ethnicity impacts the success rates of external cephalic version (ECV) in the United States
- Fetal adrenal gland size and umbilical artery Doppler in growth-restricted fetuses
- Counseling pregnant women on calcium: effects on calcium intake
- Relationship among anogenital distance, adrenal gland volume, and penile length and width at 22–36 weeks of pregnancy
- Intra-amniotic inflammation in the mid-trimester of pregnancy is a risk factor for neuropsychological disorders in childhood
- Genetic amniocentesis using atraumatic 29 gauge needle in patients having a chorioamniotic separation
- YouTube as a source of patient information on external cephalic version
- Midwives’ personal and professional attitudes towards women’s delivery choices, interventions and neonatal care
- Maternal serum midkine level in fetal growth restriction: a case-control study
- Original Articles – Neonates
- Interventions for reducing late-onset sepsis in neonates: an umbrella review
- Maternal knowledge of recommendations for safe infant sleep and intentions for implementation – a cross sectional analysis of data from the KUNO-Kids birth cohort study
- Short Communication
- Lysophosphatidylcholine acyltransferase 1 protein is present in maternal blood in the third trimester and is upregulated by antenatal corticosteroids
- Letters to the Editor
- Peripartum hysterectomy at a tertiary university perinatal center – retrospective analysis of the 25-year period
- Neonate, infected mother and monkeypox: the present concern
