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Maternal and fetal outcomes in pregnancies with obstructive sleep apnea

  • Eloise Passarella , Nicholas Czuzoj-Shulman und Haim A. Abenhaim EMAIL logo
Veröffentlicht/Copyright: 15. September 2021
Journal of Perinatal Medicine
Aus der Zeitschrift Journal of Perinatal Medicine Band 49 Heft 9

Abstract

Objectives

Obstructive sleep apnea (OSA) is linked to many health comorbidities. We aimed to ascertain if OSA correlates with a rise in poor obstetrical outcomes.

Methods

Employing the United States’ Healthcare Cost and Utilization Project – National Inpatient Sample, we performed our retrospective cohort study including all women who delivered between 2006 and 2015. ICD-9 codes were used to characterize women as having a diagnosis of OSA. Temporal trends in pregnancies with OSA were studied, baseline features were evaluated among gravidities in the presence and absence of OSA, and multivariate logistic regression analysis was utilized in assessing consequences of OSA on patient and newborn outcomes.

Results

Of a total 7,907,139 deliveries, 3,115 belonged to patients suffering from OSA, resulting in a prevalence of 39 per 100,000 deliveries. Rates rose from 10.14 to 78.12 per 100,000 deliveries during the study interval (p<0.0001). Patients diagnosed with OSA were at higher risk of having pregnancies with preeclampsia, OR 2.2 (95% CI 2.0–2.4), eclampsia, 4.1 (2.4–7.0), chorioamnionitis, 1.4 (1.2–1.8), postpartum hemorrhage, 1.4 (1.2–1.7), venous thromboembolisms, 2.7 (2.1–3.4), and to deliver by caesarean section, 2.1 (1.9–2.3). Cardiovascular and respiratory complications were also more common among these women, as was maternal death, 4.2 (2.2–8.0). Newborns of OSA patients were at elevated risk of being premature, 1.3 (1.2–1.5) and having congenital abnormalities, 2.3 (1.7–3.0).

Conclusions

Pregnancies with OSA were linked to an elevated risk of poor maternal and neonatal outcomes. During pregnancy, OSA patients should receive attentive follow-up care in a tertiary hospital.

Keywords: hypoxia; maternal outcomes; neonatal outcomes; obstructive sleep apnea; pregnancy
Corresponding author: Haim A. Abenhaim, MD MPH, Department of Obstetrics and Gynecology, Jewish General Hospital, McGill University, 3755 Chemin de la Côte-Sainte-Catherine, Montreal, QC, Canada, Phone: +1 514 340 8222x24187, Fax: +1 514 340 7564, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: The authors report no conflicts of interest.

  4. Informed consent: This study was based on data from a pre-existing publicly available database from the United States: The Healthcare Cost and Utilization Project-Nationwide Inpatient Sample (HCUP-NIS).

  5. Ethical approval: The local Institutional Review Board deemed the study exempt from review.

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Received: 2020-11-23
Accepted: 2021-05-18
Published Online: 2021-09-15
Published in Print: 2021-11-25

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Review
  3. Global incidence of intraventricular hemorrhage among extremely preterm infants: a systematic literature review
  4. Commentary
  5. Professional integrity in maternal – fetal innovation and research: an essential component of perinatal medicine
  6. WAPM Recommendations
  7. WAPM-World Association of Perinatal Medicine Practice Guidelines: Fetal central nervous system examination
  8. Corner of Academy
  9. Education in developing countries and reducing maternal mortality: a forgotten piece of the puzzle?
  10. Original Articles – Obstetrics
  11. The contemporary value of dedicated preterm birth clinics for high-risk singleton pregnancies: 15-year outcomes from a leading maternal centre
  12. Chorioamnionitis after premature rupture of membranes in nulliparas undergoing labor induction: prostaglandin E2 vs. oxytocin
  13. Maternal and fetal outcomes in pregnancies with obstructive sleep apnea
  14. Assessing the involvement of the placental microbiome and virome in preeclampsia using non coding RNA sequencing
  15. Risk of metformin failure in the treatment of women with gestational diabetes
  16. Can we improve our ability to interpret category II fetal heart rate tracings using additional clinical parameters?
  17. New obstetric systemic inflammatory response syndrome criteria for early identification of high-risk of sepsis in obstetric patients
  18. Bacteria in the amniotic fluid without inflammation: early colonization vs. contamination
  19. Intertwin differences in umbilical artery pulsatility index are associated with infant survival in twin-to-twin transfusion syndrome
  20. Maternal and neonatal outcomes in women with disorders of lipid metabolism
  21. The use of PAMG-1 testing in patients with preterm labor, intact membranes and a short sonographic cervix reduces the rate of unnecessary antenatal glucocorticoid administration
  22. Original Articles – Neonates
  23. The effect of postnatal corticosteroids on growth parameters in infants with bronchopulmonary dysplasia
  24. Are neonatal outcomes of triplet pregnancies different from those of singletons according to gestational age?
  25. Impact of paternal presence and parental social-demographic characteristics on birth outcomes
  26. Letter to the Editor
  27. Comment on: “amniotic fluid embolism – implementation of international diagnosis criteria and subsequent pregnancy recurrence risk”
https://doi.org/10.1515/jpm-2020-0551
Schlagwörter für diesen Artikel
hypoxia; maternal outcomes; neonatal outcomes; obstructive sleep apnea; pregnancy

Artikel in diesem Heft

  1. Frontmatter
  2. Review
  3. Global incidence of intraventricular hemorrhage among extremely preterm infants: a systematic literature review
  4. Commentary
  5. Professional integrity in maternal – fetal innovation and research: an essential component of perinatal medicine
  6. WAPM Recommendations
  7. WAPM-World Association of Perinatal Medicine Practice Guidelines: Fetal central nervous system examination
  8. Corner of Academy
  9. Education in developing countries and reducing maternal mortality: a forgotten piece of the puzzle?
  10. Original Articles – Obstetrics
  11. The contemporary value of dedicated preterm birth clinics for high-risk singleton pregnancies: 15-year outcomes from a leading maternal centre
  12. Chorioamnionitis after premature rupture of membranes in nulliparas undergoing labor induction: prostaglandin E2 vs. oxytocin
  13. Maternal and fetal outcomes in pregnancies with obstructive sleep apnea
  14. Assessing the involvement of the placental microbiome and virome in preeclampsia using non coding RNA sequencing
  15. Risk of metformin failure in the treatment of women with gestational diabetes
  16. Can we improve our ability to interpret category II fetal heart rate tracings using additional clinical parameters?
  17. New obstetric systemic inflammatory response syndrome criteria for early identification of high-risk of sepsis in obstetric patients
  18. Bacteria in the amniotic fluid without inflammation: early colonization vs. contamination
  19. Intertwin differences in umbilical artery pulsatility index are associated with infant survival in twin-to-twin transfusion syndrome
  20. Maternal and neonatal outcomes in women with disorders of lipid metabolism
  21. The use of PAMG-1 testing in patients with preterm labor, intact membranes and a short sonographic cervix reduces the rate of unnecessary antenatal glucocorticoid administration
  22. Original Articles – Neonates
  23. The effect of postnatal corticosteroids on growth parameters in infants with bronchopulmonary dysplasia
  24. Are neonatal outcomes of triplet pregnancies different from those of singletons according to gestational age?
  25. Impact of paternal presence and parental social-demographic characteristics on birth outcomes
  26. Letter to the Editor
  27. Comment on: “amniotic fluid embolism – implementation of international diagnosis criteria and subsequent pregnancy recurrence risk”
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